Safety and infectivity of female cercariae in Schistosoma-naïve, healthy participants: a controlled human Schistosoma mansoni infection studyResearch in context

Autor: Jan Pieter R. Koopman, Emma L. Houlder, Jacqueline J. Janse, Miriam Casacuberta-Partal, Olivia A.C. Lamers, Jeroen C. Sijtsma, Claudia de Dood, Stan T. Hilt, Arifa Ozir-Fazalalikhan, Vincent P. Kuiper, Geert V.T. Roozen, Laura M. de Bes-Roeleveld, Yvonne C.M. Kruize, Linda J. Wammes, Hermelijn H. Smits, Lisette van Lieshout, Govert J. van Dam, Inge M. van Amerongen-Westra, Pauline Meij, Paul L.A.M. Corstjens, Simon P. Jochems, Angela van Diepen, Maria Yazdanbakhsh, Cornelis H. Hokke, Meta Roestenberg

Publikováno v: EBioMedicine, Vol 97, Iss , Pp 104832- (2023)

Summary: Background: A controlled human infection model for schistosomiasis (CHI-S) can speed up vaccine development and provides insight into early immune responses following schistosome exposure. Recently, we established CHI-S model using single-se

Externí odkaz: https://doaj.org/article/47a3e655db044c188dcbfa221310dd96

Bacillus Calmette-Guérin vaccine to reduce healthcare worker absenteeism in COVID-19 pandemic, a randomized controlled trial

Autor: Thijs ten Doesschate, Thomas W. van der Vaart, Priya A. Debisarun, Esther Taks, Simone J.C.F.M. Moorlag, Nienke Paternotte, Wim G. Boersma, Vincent P. Kuiper, Anna H.E. Roukens, Bart J.A. Rijnders, Andreas Voss, Karin M. Veerman, Angele P.M. Kerckhoffs, Jaap ten Oever, Reinout van Crevel, Cees van Nieuwkoop, Arief Lalmohamed, Janneke H.H.M. van de Wijgert, Mihai G. Netea, Marc J.M. Bonten, Cornelis H. van Werkhoven

Publikováno v: Clinical Microbiology and Infection, 28, 9, pp. 1278-1285
Clinical Microbiology and Infection, 28(9), 1278-1285. ELSEVIER SCI LTD
Clinical Microbiology and Infection, 28(9), 1278-1285. Elsevier Ltd.
Clinical Microbiology and Infection, 28(9), 1278-1285
ten Doesschate, T, van der Vaart, T W, Debisarun, P A, Taks, E, Moorlag, S J C F M, Paternotte, N, Boersma, W G, Kuiper, V P, Roukens, A H E, Rijnders, B J A, Voss, A, Veerman, K M, Kerckhoffs, A P M, Oever, J T, van Crevel, R, van Nieuwkoop, C, Lalmohamed, A, van de Wijgert, J H H M, Netea, M G, Bonten, M J M & van Werkhoven, C H 2022, ' Bacillus Calmette-Guérin vaccine to reduce healthcare worker absenteeism in COVID-19 pandemic, a randomized controlled trial ', Clinical Microbiology and Infection, vol. 28, no. 9, pp. 1278-1285 . https://doi.org/10.1016/j.cmi.2022.04.009
Clinical Microbiology and Infection, 28, 1278-1285

Objectives: The COVID-19 pandemic increases healthcare worker (HCW) absenteeism. The bacillus Calmette-Gue?rin (BCG) vaccine may provide non-specific protection against respiratory infections through enhancement of trained immunity. We investigated t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0978cbd17d01bbafaf6d1b9840fdcdf1
http://www.scopus.com/inward/record.url?scp=85130805747&partnerID=8YFLogxK

Safety and Immunogenicity of Intradermal Fractional Dose Administration of the mRNA-1273 Vaccine: A Proof-of-Concept Study

Autor: Geert V.T. Roozen, Margaretha L.M. Prins, Rob van Binnendijk, Gerco den Hartog, Vincent P. Kuiper, Corine Prins, Jacqueline J. Janse, Annelieke C. Kruithof, Mariet C.W. Feltkamp, Marjan Kuijer, Frits R. Rosendaal, Meta Roestenberg, Leo G. Visser, Anna H.E. Roukens

Publikováno v: Annals of Internal Medicine. AMER COLL PHYSICIANS
Annals of Internal Medicine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71344eb25670de5c89ef3026b6ac2de6
https://hdl.handle.net/1887/3514839

Nintedanib improves cardiac fibrosis but leaves pulmonary vascular remodelling unaltered in experimental pulmonary hypertension

Autor: Ly Tu, Franziska Herrmann, Xiaoke Pan, Robert Szulcek, Frances S. de Man, Anton Vonk-Noordegraaf, Geerten P. van Nieuw Amerongen, Harm Jan Bogaard, Chris Dickhoff, Kondababu Kurakula, Christophe Guignabert, Michiel Alexander de Raaf, Denielli da Silva Goncalves Bos, Nina Rol, Vincent P Kuiper, Kirsten Lodder, Xiaoqing Q Sun, Pieter Koolwijk, Chris Happé, Ingrid Schalij, Raphaël Thuillet, Marie-José Goumans, Lutz Wollin

Publikováno v: Cardiovascular Research, 115(2), 432-439. Oxford University Press
Rol, N, de Raaf, M A, Sun, X Q, Kuiper, V P, da Silva Gonçalves Bos, D, Happé, C, Kurakula, K, Dickhoff, C, Thuillet, R, Tu, L, Guignabert, C, Schalij, I, Lodder, K, Pan, X, Herrmann, F E, van Nieuw Amerongen, G P, Koolwijk, P, Vonk-Noordegraaf, A, de Man, F S, Wollin, L, Goumans, M-J, Szulcek, R & Bogaard, H J 2019, ' Nintedanib improves cardiac fibrosis but leaves pulmonary vascular remodelling unaltered in experimental pulmonary hypertension ', Cardiovascular Research, vol. 115, no. 2, pp. 432-439 . https://doi.org/10.1093/cvr/cvy186, https://doi.org/10.1093/cvr/cvy186
Cardiovascular Research, 115(2), 432-439. OXFORD UNIV PRESS

Aims: Pulmonary arterial hypertension (PAH) is associated with increased levels of circulating growth factors and corresponding receptors such as platelet derived growth factor, fibroblast growth factor and vascular endothelial growth factor. Ninteda

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24f69fccf1fee5850e4963063aac06e1
http://www.scopus.com/inward/record.url?scp=85060365403&partnerID=8YFLogxK

Assessment of Risks Associated With Severe Acute Respiratory Syndrome Coronavirus 2 Experimental Human Infection Studies

Autor: Ingrid M C Kamerling, Meta Roestenberg, Frits R. Rosendaal, Vincent P. Kuiper, Leonardus Gerardus Visser

Publikováno v: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Clinical Infectious Diseases
Clinical Infectious Diseases, 73(5), E1228-E1234. OXFORD UNIV PRESS INC

Controlled human infection (CHI) models for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been proposed as a tool to accelerate the development of vaccines and drugs. Such models carry inherent risks. Participants may develop seve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecad043cae8ee24c547a1563b2dc2875
https://pubmed.ncbi.nlm.nih.gov/33249450