Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Vincent M. Luo"'
Autor:
Ramya Raviram, Pedro P. Rocha, Vincent M. Luo, Emily Swanzey, Emily R. Miraldi, Edward B. Chuong, Cédric Feschotte, Richard Bonneau, Jane A. Skok
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-19 (2018)
Abstract Background The organization of chromatin in the nucleus plays an essential role in gene regulation. About half of the mammalian genome comprises transposable elements. Given their repetitive nature, reads associated with these elements are g
Externí odkaz:
https://doaj.org/article/3a0a5fa813a5476db6e985eceb04da19
Autor:
Pedro P. Rocha, Ramya Raviram, Yi Fu, JungHyun Kim, Vincent M. Luo, Arafat Aljoufi, Emily Swanzey, Alessandra Pasquarella, Alessia Balestrini, Emily R. Miraldi, Richard Bonneau, John Petrini, Gunnar Schotta, Jane A. Skok
Publikováno v:
Cell Reports, Vol 16, Iss 1, Pp 48-55 (2016)
During class switch recombination (CSR), B cells replace the Igh Cμ or δ exons with another downstream constant region exon (CH), altering the antibody isotype. CSR occurs through the introduction of AID-mediated double-strand breaks (DSBs) in swit
Externí odkaz:
https://doaj.org/article/266e49fa1aa343f48941d304bb2ad84b
Autor:
Yi Fu, Pedro P. Rocha, Vincent M. Luo, Ramya Raviram, Yan Deng, Esteban O. Mazzoni, Jane A. Skok
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
The ability to target Cas9 to specific genomic loci offers the potential for applications beyond genome editing. Here the authors use deactivated Cas9 and chimeric guide RNAs to visualise individual repetitive loci in living cells.
Externí odkaz:
https://doaj.org/article/635bafc37e314ac384163cddf0d14810
Autor:
Josie Ursini-Siegel, Steven Findlay, Jeesan Lee, Jean-François Côté, Alexandre Orthwein, Alexandre Maréchal, Martin Karam, Edgar Pinedo Carpio, Stéphane Richard, Benjamin Lebeau, Vincent M Luo, Billel Djerir, Damien Grapton, Xiaoru Chen, Estelle Simo Cheyou, Halil Bagci, John K. Heath, Michael Witcher, Théo Morin
Publikováno v:
EMBO Rep
The heterochromatin protein HP1 plays a central role in the maintenance of genome stability but little is known about how HP1 is controlled. Here, we show that the zinc finger protein POGZ promotes the presence of HP1 at DNA double‐strand breaks (D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3a2ceae26b097e5b7517fd8925bb21b
https://europepmc.org/articles/PMC8728601/
https://europepmc.org/articles/PMC8728601/
Autor:
Estelle Simo Cheyou, Benjamin Lebeau, Alexandre Maréchal, Michael Witcher, Steven Findlay, Damien Grapton, Halil Bagci, Josie Ursini-Siegel, Stéphane Richard, Carpio Ep, Chen X, Lee J, John K. Heath, Théo Morin, Billel Djerir, Vincent M Luo, Alexandre Orthwein, Jean-François Côté, Martin Karam
The heterochromatin protein HP1 plays a central role in the maintenance of genome stability, in particular by promoting homologous recombination (HR)-mediated DNA repair. However, little is still known about how HP1 is controlled during this process.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32d10bce464aa5d97319a47855d5965d
https://doi.org/10.1101/2021.06.28.447216
https://doi.org/10.1101/2021.06.28.447216
Autor:
Bernardo Reina-San-Martin, Pedro P. Rocha, Anne-Sophie Thomas-Claudepierre, Jane A. Skok, Isabelle Robert, Vincent M. Luo, Tilman Borggrefe, Ebe Schiavo, Janardan K. Reddy, Richard Bonneau, Vincent Heyer, Ramya Raviram
Publikováno v:
The Journal of Experimental Medicine
Thomas-Claudepierre et al. report that mediator facilitates the long-range contacts between acceptor switch regions and the IgH locus enhancers during class switch recombination and their transcriptional activation.
Immunoglobulin (Ig) class swi
Immunoglobulin (Ig) class swi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc1120f3a66752cdfe8ea9230b0471ba
http://europepmc.org/articles/PMC4813673
http://europepmc.org/articles/PMC4813673
Autor:
Yan Coulombe, Morag Park, Celia M. T. Greenwood, Koren K. Mann, Alexandre Orthwein, Zhigang Li, Jean-Yves Masson, Estelle Simo-Cheyou, Théo Morin, Jean-François Côté, Elise G Lavoie, Yuval Tabach, Steven Findlay, Martin Karam, Vincent M Luo, Damien Grapton, Christian Dove, Billel Djerir, Husam Khaled, Hellen Kuasne, Halil Bagci, Abba Malina, Arash Samiei, Alexandre Maréchal, Kathleen Oros Klein, Dolev Rahat, John E. Heath
Publikováno v:
The EMBO Journal
DNA double‐strand breaks (DSBs) can be repaired by two major pathways: non‐homologous end‐joining (NHEJ) and homologous recombination (HR). DNA repair pathway choice is governed by the opposing activities of 53BP1, in complex with its effectors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f62dd9d602ec577d1292b1d849919e6a
http://europepmc.org/articles/PMC6138439
http://europepmc.org/articles/PMC6138439
Autor:
Vincent M Luo, Elise G Lavoie, Steven Findlay, Halil Bagci, Abba Malina, Jean-François Côté, Arash Samiei, John E. Heath, Dolev Rahat, Damien Grapton, Estelle Simo Cheyou, Alexandre Maréchal, Christian Dove, Kathleen Oros Klein, Martin Karam, Billel Djerir, Hellen Kuasne, Théo Morin, Morag Park, Alexandre Orthwein, Yuval Tabach, Husam Khaled, Koren K. Mann, Zhigang Li
SUMMARYDNA double-strand breaks (DSBs) can be repaired by two major pathways: non-homologous end-joining (NHEJ) and homologous recombination (HR). DNA repair pathway choice is governed by the opposing activities of 53BP1, in complex with its effector
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f58e44a383851c56dd15f8606fd0df74
https://doi.org/10.1101/365460
https://doi.org/10.1101/365460
Autor:
Emily Swanzey, Emily R. Miraldi, Richard Bonneau, Edward B. Chuong, Jane A. Skok, Pedro P. Rocha, Ramya Raviram, Vincent M. Luo, Cédric Feschotte
BackgroundThe organization of chromatin in the nucleus plays an essential role in gene regulation. When considering the mammalian genome it is important to take into account that about half of the DNA is comprised of transposable elements. Given thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea0def28fca995b03c70d01635ccda4
https://doi.org/10.1101/295329
https://doi.org/10.1101/295329
Autor:
Richard Bonneau, Pedro P. Rocha, Jane A. Skok, Vincent M. Luo, Ramya Raviram, Emily R. Miraldi, Edward B. Chuong, Cédric Feschotte, Emily Swanzey
Publikováno v:
Genome Biology
Genome Biology, Vol 19, Iss 1, Pp 1-19 (2018)
Genome Biology, Vol 19, Iss 1, Pp 1-19 (2018)
Background The organization of chromatin in the nucleus plays an essential role in gene regulation. About half of the mammalian genome comprises transposable elements. Given their repetitive nature, reads associated with these elements are generally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d4343653d278dd6bf191f5e12f0223
https://pubmed.ncbi.nlm.nih.gov/30541598
https://pubmed.ncbi.nlm.nih.gov/30541598