Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Vincent M. Hunt"'
Publikováno v:
Journal of the Chinese Chemical Society. 43:451-457
Reversed-phase high-performance liquid chromatography (RP-HPLC) was used as a tool to explore the retention behavior and separation of four 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, namely compactin, lovastatin, simvastati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfb278b418459c989ca413b176f92858
https://doi.org/10.1002/jccs.199600065
https://doi.org/10.1002/jccs.199600065
Autor:
J. S. Chen, John D. Karkas, Vincent M. Hunt, Alfred W. Alberts, Y. Chao, R. Liou, G. W. Kuron
Publikováno v:
European Journal of Clinical Pharmacology. 40:S11-S14
Lovastatin and simvastatin are potent competitive inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Key inhibit the synthesis of cholesterol in cultured HepG23 cells, rat hepatocytes and in rats. The primary target organ of cholesterol s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1680d8c6b5679b8c5075a199e4481d68
https://doi.org/10.1007/bf01409400
https://doi.org/10.1007/bf01409400
Publikováno v:
Archives of Biochemistry and Biophysics. 129:264-272
Dietary 5β-cholanic acid in the mouse caused a marked reduction of plasma cholesterol, an increase in rate of excretion of intraperitoneally administered 14 C-labeled cholic and chenodeoxycholic acids and an increase in rate of excretion of orally a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2f0957975040a8e9b4de6ac45c64892
https://doi.org/10.1016/0003-9861(69)90174-x
https://doi.org/10.1016/0003-9861(69)90174-x
Autor:
Alfred W. Alberts, Richard G. Bostedor, John D. Karkas, John I. Germershausen, Vincent M. Hunt, Philip J. Bailey
Publikováno v:
Biochemical and biophysical research communications. 158(3)
Tissue selectivity of lovastatin, simvastatin and pravastatin was determined in male rats. Peak levels of active drug were found in all tissues examined between 0.5 and 2 hours after oral administration. The area under the curve describing 24 hour ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98ceb186762149efd666b062d8593dec
https://pubmed.ncbi.nlm.nih.gov/2493245
https://pubmed.ncbi.nlm.nih.gov/2493245
Publikováno v:
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 136(4)
Summary2-Acetoamidoethyl (p-chlorophenyl) (m-trifluoromethylphenoxy) acetate (halofenate) has been established as a potent hypolipemic agent in the rat, significantly lowering, in a dose-response relationship, plasma cholesterol, triglycerides, phosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0929326eae6bbd10b2ce9502a80aa85b
https://pubmed.ncbi.nlm.nih.gov/5554475
https://pubmed.ncbi.nlm.nih.gov/5554475