Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Vincent M. Bruno"'
Autor:
Povilas Kavaliauskas, Yiyou Gu, Naushaba Hasin, Karen T. Graf, Abdullah Alqarihi, Amol C. Shetty, Carrie McCracken, Thomas J. Walsh, Ashraf S. Ibrahim, Vincent M. Bruno
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract During pulmonary mucormycosis, inhaled sporangiospores adhere to, germinate, and invade airway epithelial cells to establish infection. We provide evidence that HIF1α plays dual roles in airway epithelial cells during Mucorales infection. W
Externí odkaz:
https://doaj.org/article/759c656495cf48bf9e8817fa4689eea1
Autor:
Jeffrey M. Rybak, Jinhong Xie, Adela Martin-Vicente, Xabier Guruceaga, Harrison I. Thorn, Ashley V. Nywening, Wenbo Ge, Ana C. O. Souza, Amol C. Shetty, Carrie McCracken, Vincent M. Bruno, Josie E. Parker, Steven L. Kelly, Hannah M. Snell, Christina A. Cuomo, P. David Rogers, Jarrod R. Fortwendel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Triazole antifungals function as ergosterol biosynthesis inhibitors and are frontline therapy for invasive fungal infections, such as invasive aspergillosis. The primary mechanism of action of triazoles is through the specific inhibition of
Externí odkaz:
https://doaj.org/article/f05294528fb640d8a22b184dae7ef4b2
Autor:
Alexandra Y. Soare, Vincent M. Bruno
Publikováno v:
mBio, Vol 15, Iss 1 (2024)
ABSTRACTMucormycosis is classified by the National Institute of Allergy and Infectious Diseases as an emerging disease and is caused by Mucorales fungi. Despite the high morbidity and mortality rates associated with the disease, little is known about
Externí odkaz:
https://doaj.org/article/81662ff2f13f4c29b967633f202931e2
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 4 (2023)
ABSTRACT Invasive aspergillosis is initiated when Aspergillus fumigatus adheres to and invades the pulmonary epithelial cells that line the airways and alveoli. To gain deeper insight into how pulmonary epithelial cells respond to A. fumigatus invasi
Externí odkaz:
https://doaj.org/article/174ba912379d47f2b76101e0e36c1c74
Publikováno v:
mBio, Vol 14, Iss 3 (2023)
ABSTRACT Aspergillus fumigatus is an environmental fungus that can cause life-threatening pulmonary disease. Infections initiate when conidia are inhaled and land deep inside the small airways and alveoli of the lungs, where they interact with epithe
Externí odkaz:
https://doaj.org/article/e749b9b12c92426190157567cdf16429
Autor:
Md Shamsuzzaman, Nusrat Rahman, Brian Gregory, Ananth Bommakanti, Janice M. Zengel, Vincent M. Bruno, Lasse Lindahl
Publikováno v:
mSystems, Vol 8, Iss 1 (2023)
ABSTRACT Many mutations in genes for ribosomal proteins (r-proteins) and assembly factors cause cell stress and altered cell fate, resulting in congenital diseases collectively called ribosomopathies. Even though all such mutations depress the cell
Externí odkaz:
https://doaj.org/article/b77a3049c24e488fab4d47f8744a586e
Autor:
Taissa Vila, Eric F. Kong, Daniel Montelongo-Jauregui, Patrick Van Dijck, Amol C. Shetty, Carrie McCracken, Vincent M. Bruno, Mary Ann Jabra-Rizk
Publikováno v:
Virulence, Vol 12, Iss 1, Pp 835-851 (2021)
Biofilm-associated polymicrobial infections tend to be challenging to treat. Candida albicans and Staphylococcus aureus are leading pathogens due to their ability to form biofilms on medical devices. However, the therapeutic implications of their int
Externí odkaz:
https://doaj.org/article/d87298cb93ee44fe958c2e0d3cbad180
Autor:
Felix E.Y. Aggor, Martinna Bertolini, Chunsheng Zhou, Tiffany C. Taylor, Darryl A. Abbott, Javonn Musgrove, Vincent M. Bruno, Timothy W. Hand, Sarah L. Gaffen
Publikováno v:
JCI Insight, Vol 7, Iss 18 (2022)
A side effect of antibiotics is outgrowth of the opportunistic fungus Candida albicans in the oropharynx (oropharyngeal candidiasis, OPC). IL-17 signaling is vital for immunity to OPC, but how the microbiome impacts antifungal immunity is not well un
Externí odkaz:
https://doaj.org/article/3e7129f8a12d4d8baf5f4651693398d2
Autor:
Eric S. Tvedte, Jane Michalski, Shaoji Cheng, Rayanna S. Patkus, Luke J. Tallon, Lisa Sadzewicz, Vincent M. Bruno, Joana C. Silva, David A. Rasko, Julie C. Dunning Hotopp
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Library preparation for high-throughput sequencing applications is a critical step in producing representative, unbiased sequencing data. The iGenomX Riptide High Throughput Rapid Library Prep Kit purports to provide high-quality sequencing
Externí odkaz:
https://doaj.org/article/d6cf97eb6bf54e5e90994b284e4dc181
Autor:
Matthew Chung, Vincent M. Bruno, David A. Rasko, Christina A. Cuomo, José F. Muñoz, Jonathan Livny, Amol C. Shetty, Anup Mahurkar, Julie C. Dunning Hotopp
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-23 (2021)
Abstract Advances in transcriptome sequencing allow for simultaneous interrogation of differentially expressed genes from multiple species originating from a single RNA sample, termed dual or multi-species transcriptomics. Compared to single-species
Externí odkaz:
https://doaj.org/article/88f8221297974a8dac07934a265c6727