Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Vincent M Isabella"'
Autor:
Aida Kalantari, Michael J James, Lauren A Renaud, Mylene Perreault, Catherine E Monahan, Mary N McDonald, David L Hava, Vincent M Isabella
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0280499 (2023)
E. coli Nissle (EcN) is a non-pathogenic probiotic bacterium of the Enterobacteriaceae family that has been used for over a century to promote general gut health. Despite the history of safe usage of EcN, concerns have been raised regarding the prese
Externí odkaz:
https://doaj.org/article/8e875cfb2bbe4ee59d9f23a67d648b46
Autor:
David Lubkowicz, Nicholas G Horvath, Michael J James, Pasquale Cantarella, Lauren Renaud, Christopher G Bergeron, Ron B Shmueli, Cami Anderson, Jian‐Rong Gao, Caroline B Kurtz, Mylene Perreault, Mark R Charbonneau, Vincent M Isabella, David L Hava
Publikováno v:
Molecular Systems Biology, Vol 18, Iss 3, Pp n/a-n/a (2022)
Abstract Enteric hyperoxaluria (EH) is a metabolic disease caused by excessive absorption of dietary oxalate leading to the formation of chronic kidney stones and kidney failure. There are no approved pharmaceutical treatments for EH. SYNB8802 is an
Externí odkaz:
https://doaj.org/article/b6d895d2871d4ce49bd1ee066df28241
Autor:
Kristin J. Adolfsen, Isolde Callihan, Catherine E. Monahan, Per Jr. Greisen, James Spoonamore, Munira Momin, Lauren E. Fitch, Mary Joan Castillo, Lindong Weng, Lauren Renaud, Carl J. Weile, Jay H. Konieczka, Teodelinda Mirabella, Andres Abin-Fuentes, Adam G. Lawrence, Vincent M. Isabella
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
PKU patients have elevated phenylalanine levels which can result in neurological impairment. Here the authors utilize biosensor-based ultra-high-throughput screening to optimize PAL activity in a synthetic biotic platform for improved in vivo perform
Externí odkaz:
https://doaj.org/article/026a2581af754d8aa8526f2be41ac1f4
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
The role microbes play in human health and the ability of synthetic biology to engineer microbial properties opens up new ways of treating disease. In this perspective, the authors describe the design and development of these living therapeutics.
Externí odkaz:
https://doaj.org/article/26fba4ca08df4eda919a1a6132d74277
Autor:
Lauren E Fitch, Vincent M. Isabella, Kristin J. Adolfsen, Munira Momin, Teodelinda Mirabella, Adam G Lawrence, James E. Spoonamore, Per Jr Greisen, Andres Abin-Fuentes, Isolde Callihan, Mary Castillo, Lauren Renaud, Carl J Weile, Catherine E Monahan, Lindong Weng, Jay H Konieczka
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
In phenylketonuria (PKU) patients, a genetic defect in the enzyme phenylalanine hydroxylase (PAH) leads to elevated systemic phenylalanine (Phe), which can result in severe neurological impairment. As a treatment for PKU, Escherichia coli Nissle (EcN
Autor:
Aoife M. Brennan, Larry Blankstein, Mark R. Charbonneau, Mary Castillo, John A. Phillips, Benjamin D. Goodlett, William S. Denney, Caroline B. Kurtz, David A. Wagner, Jerry Vockley, Marja K. Puurunen, Stephanie Sacharow, Vincent M. Isabella, Vasu V. Sethuraman, Richard Riese, Shawn Searle
Publikováno v:
Nature Metabolism. 3:1125-1132
Phenylketonuria (PKU) is a rare disease caused by biallelic mutations in the PAH gene that result in an inability to convert phenylalanine (Phe) to tyrosine, elevated blood Phe levels and severe neurological complications if untreated. Most patients
Autor:
Natalie Artzi, Sidi A. Bencherif, Rachel Berryman, Khushbu Bhatt, Aoife M. Brennan, Sue Anne Chew, Alexander M. Cryer, Serena Danti, Nicholas DePatie, Sashana Dixon, Loek J. Eggermont, Samantha C. Emery, Reilly Fankhauser, Kristin Huntoon, Vincent M. Isabella, Wen Jiang, Emily M. Jordan, Betty Y.S. Kim, Stephen J. Kron, Rajan P. Kulkarni, Amrendra Kumar, DaeYong Lee, Steve Seung-Young Lee, Ning Li, Olivia M. Lucero, Mario Milazzo, Miles A. Miller, Xuan Mu, Thomas S.C. Ng, Joanna Pagacz, Praseet Poduval, Jai Prakash, Matthew Schrier, Kai Shi, Amit Singh, Anna Sokolovska, Alice Tran, Malav Trivedi, Irene Uboldi, Anna E. Vilgelm, Kevin P. Weller, Yi-Chien Wu, Yu Shrike Zhang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cb44dcb1b5f0eab7c79c2c670810267
https://doi.org/10.1016/b978-0-323-90949-5.09989-7
https://doi.org/10.1016/b978-0-323-90949-5.09989-7
Autor:
Marja K. Puurunen, Jerry Vockley, Shawn L. Searle, Stephanie J. Sacharow, John A. Phillips, William S. Denney, Benjamin D. Goodlett, David A. Wagner, Larry Blankstein, Mary J. Castillo, Mark R. Charbonneau, Vincent M. Isabella, Vasu V. Sethuraman, Richard J. Riese, Caroline B. Kurtz, Aoife M. Brennan
Publikováno v:
Nature Metabolism. 4:1214-1214
Autor:
Marja K, Puurunen, Jerry, Vockley, Shawn L, Searle, Stephanie J, Sacharow, John A, Phillips, William S, Denney, Benjamin D, Goodlett, David A, Wagner, Larry, Blankstein, Mary J, Castillo, Mark R, Charbonneau, Vincent M, Isabella, Vasu V, Sethuraman, Richard J, Riese, Caroline B, Kurtz, Aoife M, Brennan
Publikováno v:
Nature metabolism. 3(8)
Phenylketonuria (PKU) is a rare disease caused by biallelic mutations in the PAH gene that result in an inability to convert phenylalanine (Phe) to tyrosine, elevated blood Phe levels and severe neurological complications if untreated. Most patients
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
A complex interplay of metabolic and immunological mechanisms underlies many diseases that represent a substantial unmet medical need. There is an increasing appreciation of the role microbes play in human health and disease, and evidence is accumula