Zobrazeno 1 - 10
of 309
pro vyhledávání: '"Vincent M Christoffels"'
Autor:
Fernanda M Bosada, Karel van Duijvenboden, Alexandra E Giovou, Mathilde R Rivaud, Jae-Sun Uhm, Arie O Verkerk, Bastiaan J Boukens, Vincent M Christoffels
Publikováno v:
eLife, Vol 12 (2023)
Heart development and rhythm control are highly Tbx5 dosage-sensitive. TBX5 haploinsufficiency causes congenital conduction disorders, whereas increased expression levels of TBX5 in human heart samples has been associated with atrial fibrillation (AF
Externí odkaz:
https://doaj.org/article/6c9f0c237a34499487c877a31f70329b
Autor:
Alexandra Wiesinger, Jiuru Li, Lianne Fokkert, Priscilla Bakker, Arie O Verkerk, Vincent M Christoffels, Gerard JJ Boink, Harsha D Devalla
Publikováno v:
eLife, Vol 11 (2022)
Each heartbeat is triggered by the sinoatrial node (SAN), the primary pacemaker of the heart. Studies in animal models have revealed that pacemaker cells share a common progenitor with the (pro)epicardium, and that the pacemaker cardiomyocytes furthe
Externí odkaz:
https://doaj.org/article/17bc9b7e4c9f4f619baccc66fec6fcc9
Autor:
Federico Tessadori, Erika Tsingos, Enrico Sandro Colizzi, Fabian Kruse, Susanne C van den Brink, Malou van den Boogaard, Vincent M Christoffels, Roeland MH Merks, Jeroen Bakkers
Publikováno v:
eLife, Vol 10 (2021)
Organ laterality refers to the left-right asymmetry in disposition and conformation of internal organs and is established during embryogenesis. The heart is the first organ to display visible left-right asymmetries through its left-sided positioning
Externí odkaz:
https://doaj.org/article/7923d5ceebef49e488dda295e3acdc31
Autor:
Jan Hendrik van Weerd, Rajiv A Mohan, Karel van Duijvenboden, Ingeborg B Hooijkaas, Vincent Wakker, Bastiaan J Boukens, Phil Barnett, Vincent M Christoffels
Publikováno v:
eLife, Vol 9 (2020)
Genome-wide association studies have implicated common genomic variants in the gene desert upstream of TBX3 in cardiac conduction velocity. Whether these noncoding variants affect expression of TBX3 or neighboring genes and how they affect cardiac co
Externí odkaz:
https://doaj.org/article/46aaf9b6deb8477aad93b64460517e7b
Autor:
Bjarke Jensen, Bastiaan J Boukens, Dane A Crossley II, Justin Conner, Rajiv A Mohan, Karel van Duijvenboden, Alex V Postma, Christopher R Gloschat, Ruth M Elsey, David Sedmera, Igor R Efimov, Vincent M Christoffels
Publikováno v:
eLife, Vol 7 (2018)
Mammals and birds have a specialized cardiac atrioventricular conduction system enabling rapid activation of both ventricles. This system may have evolved together with high heart rates to support their endothermic state (warm-bloodedness) and is see
Externí odkaz:
https://doaj.org/article/5fcfe392352d4541a30312ae3ea07766
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156787 (2016)
The epicardium, the outermost layer of the heart, is an essential source of cells and signals for the formation of the cardiac fibrous skeleton and the coronary vasculature, and for the maturation of the myocardium during embryonic development. The m
Externí odkaz:
https://doaj.org/article/eac43e913449404d9c4762a4e073a01f
Autor:
Manon Baudic, Hiroshige Murata, Fernanda M. Bosada, Uirá Souto Melo, Takanori Aizawa, Pierre Lindenbaum, Lieve E. van der Maarel, Amaury Guedon, Estelle Baron, Enora Fremy, Adrien Foucal, Taisuke Ishikawa, Hiroya Ushinohama, Sean J. Jurgens, Seung Hoan Choi, Florence Kyndt, Solena Le Scouarnec, Vincent Wakker, Aurélie Thollet, Annabelle Rajalu, Tadashi Takaki, Seiko Ohno, Wataru Shimizu, Minoru Horie, Takeshi Kimura, Patrick T. Ellinor, Florence Petit, Yves Dulac, Paul Bru, Anne Boland, Jean-François Deleuze, Richard Redon, Hervé Le Marec, Thierry Le Tourneau, Jean-Baptiste Gourraud, Yoshinori Yoshida, Naomasa Makita, Claude Vieyres, Takeru Makiyama, Stephan Mundlos, Vincent M. Christoffels, Vincent Probst, Jean-Jacques Schott, Julien Barc
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract While 3D chromatin organization in topologically associating domains (TADs) and loops mediating regulatory element-promoter interactions is crucial for tissue-specific gene regulation, the extent of their involvement in human Mendelian disea
Externí odkaz:
https://doaj.org/article/973ce46b9b9a4d84b5710238b42950a4
Autor:
Bouke A de Boer, Karel van Duijvenboden, Malou van den Boogaard, Vincent M Christoffels, Phil Barnett, Jan M Ruijter
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99844 (2014)
ChIP-seq has become a major tool for the genome-wide identification of transcription factor binding or histone modification sites. Most peak-calling algorithms require input control datasets to model the occurrence of background reads to account for
Externí odkaz:
https://doaj.org/article/e4a77da7678344d68163829ebc516de0
Autor:
Kamini Kunasegaran, Victor Ho, Ted H-T Chang, Duvini De Silva, Martijn L Bakker, Vincent M Christoffels, Alexandra M Pietersen
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110191 (2014)
The transcriptional repressor Tbx3 is involved in lineage specification in several tissues during embryonic development. Germ-line mutations in the Tbx3 gene give rise to Ulnar-Mammary Syndrome (comprising reduced breast development) and Tbx3 is requ
Externí odkaz:
https://doaj.org/article/4b372e78434c49caa89df327d62af04f
Tbx2 terminates shh/fgf signaling in the developing mouse limb bud by direct repression of gremlin1.
Autor:
Henner F Farin, Timo H-W Lüdtke, Martina K Schmidt, Susann Placzko, Karin Schuster-Gossler, Marianne Petry, Vincent M Christoffels, Andreas Kispert
Publikováno v:
PLoS Genetics, Vol 9, Iss 4, p e1003467 (2013)
Vertebrate limb outgrowth is driven by a positive feedback loop that involves Sonic hedgehog (Shh) and Gremlin1 (Grem1) in the posterior limb bud mesenchyme and Fibroblast growth factors (Fgfs) in the overlying epithelium. Proper spatio-temporal cont
Externí odkaz:
https://doaj.org/article/a15249ecec5e4ede80a199ea50d7dc18