Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Vincent Lejour"'
Autor:
Anne Fajac, Iva Simeonova, Julia Leemput, Marc Gabriel, Aurélie Morin, Vincent Lejour, Annaïg Hamon, Jeanne Rakotopare, Wilhelm Vaysse-Zinkhöfer, Eliana Eldawra, Marina Pinskaya, Antonin Morillon, Jean-Christophe Bourdon, Boris Bardot, Franck Toledo
Publikováno v:
eLife, Vol 13 (2024)
The Trp53 gene encodes several isoforms of elusive biological significance. Here, we show that mice lacking the Trp53 alternatively spliced (AS) exon, thereby expressing the canonical p53 protein but not isoforms with the AS C-terminus, have unexpect
Externí odkaz:
https://doaj.org/article/24d352706ace432cafb1b14b25ca0b61
Autor:
Jeanne Rakotopare, Vincent Lejour, Carla Duval, Eliana Eldawra, Hugues Escoffier, Franck Toledo
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 10 (2023)
Externí odkaz:
https://doaj.org/article/7a235b2394394a478c7f47ce7a6861ae
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
P53 is regarded as the guardian of the genome, however it is known that mice with increased p53 activity display characteristics of dyskeratosis congenita. Here the authors show that increased p53 activity leads to the repression of telomere maintena
Externí odkaz:
https://doaj.org/article/980839b6474840f591fdd5fbe70b2a32
Autor:
Iva Simeonova, Sara Jaber, Irena Draskovic, Boris Bardot, Ming Fang, Rachida Bouarich-Bourimi, Vincent Lejour, Laure Charbonnier, Claire Soudais, Jean-Christophe Bourdon, Michel Huerre, Arturo Londono-Vallejo, Franck Toledo
Publikováno v:
Cell Reports, Vol 3, Iss 6, Pp 2046-2058 (2013)
Mutations in p53, although frequent in human cancers, have not been implicated in telomere-related syndromes. Here, we show that homozygous mutant mice expressing p53Δ31, a p53 lacking the C-terminal domain, exhibit increased p53 activity and suffer
Externí odkaz:
https://doaj.org/article/686d4f67f2fc40f1a5ee582240159315
Autor:
Iva Simeonova, Vincent Lejour, Boris Bardot, Rachida Bouarich-Bourimi, Aurélie Morin, Ming Fang, Laure Charbonnier, Franck Toledo
Publikováno v:
PLoS Genetics, Vol 8, Iss 6, p e1002731 (2012)
Evolutionary forces that shape regulatory networks remain poorly understood. In mammals, the Rb pathway is a classic example of species-specific gene regulation, as a germline mutation in one Rb allele promotes retinoblastoma in humans, but not in mi
Externí odkaz:
https://doaj.org/article/1d8fff3c538b4d53a41141e9eb573efc
Autor:
Eléonore, Toufektchan, Vincent, Lejour, Romane, Durand, Neelam, Giri, Irena, Draskovic, Boris, Bardot, Pierre, Laplante, Sara, Jaber, Blanche P, Alter, José-Arturo, Londono-Vallejo, Sharon A, Savage, Franck, Toledo
Publikováno v:
Science Advances
We demonstrate a direct link between germline p53 activation and telomere dysfunction.
Dyskeratosis congenita is a cancer-prone inherited bone marrow failure syndrome caused by telomere dysfunction. A mouse model recently suggested that p53 regu
Dyskeratosis congenita is a cancer-prone inherited bone marrow failure syndrome caused by telomere dysfunction. A mouse model recently suggested that p53 regu
Autor:
Monica Naughtin, Geneviève Almouzni, Dan Filipescu, Zachary A. Gurard-Levin, Iva Simeonova, Vincent Lejour, Laura D. Attardi, Katrina Podsypanina, Laurence O.W. Wilson, Guillermo A. Orsi, Franck Toledo, Eléonore Toufektchan
Publikováno v:
Genes and Development
Genes and Development, Cold Spring Harbor Laboratory Press, 2017, 31 (5), pp.463-480. ⟨10.1101/gad.290924.116⟩
Genes and Development, 2017, 31 (5), pp.463-480. ⟨10.1101/gad.290924.116⟩
Genes & Development
Genes and Development, Cold Spring Harbor Laboratory Press, 2017, 31 (5), pp.463-480. ⟨10.1101/gad.290924.116⟩
Genes and Development, 2017, 31 (5), pp.463-480. ⟨10.1101/gad.290924.116⟩
Genes & Development
In mammals, centromere definition involves the histone variant CENP-A (centromere protein A), deposited by its chaperone, HJURP (Holliday junction recognition protein). Alterations in this process impair chromosome segregation and genome stability, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceea7a43f033f5072fa9ef0f6c4a71c3
https://hal.sorbonne-universite.fr/hal-01504857
https://hal.sorbonne-universite.fr/hal-01504857
Autor:
Sara Jaber, Ming Fang, Michel Huerre, Boris Bardot, Laure Charbonnier, Claire Soudais, Franck Toledo, Rachida Bouarich-Bourimi, Jean-Christophe Bourdon, Iva Simeonova, Irena Draskovic, Vincent Lejour, Arturo Londoño-Vallejo
Publikováno v:
Cell Reports
Cell Reports, Elsevier Inc, 2013, 3 (6), pp.2046-2058. ⟨10.1016/j.celrep.2013.05.028⟩
Cell Reports, 2013, 3 (6), pp.2046-2058. ⟨10.1016/j.celrep.2013.05.028⟩
Cell Reports, Elsevier Inc, 2013, 3 (6), pp.2046-2058. 〈10.1016/j.celrep.2013.05.028〉
Cell Reports, Vol 3, Iss 6, Pp 2046-2058 (2013)
Cell Reports, Elsevier Inc, 2013, 3 (6), pp.2046-2058. ⟨10.1016/j.celrep.2013.05.028⟩
Cell Reports, 2013, 3 (6), pp.2046-2058. ⟨10.1016/j.celrep.2013.05.028⟩
Cell Reports, Elsevier Inc, 2013, 3 (6), pp.2046-2058. 〈10.1016/j.celrep.2013.05.028〉
Cell Reports, Vol 3, Iss 6, Pp 2046-2058 (2013)
International audience; Mutations in p53, although frequent in human cancers , have not been implicated in telomere-related syndromes. Here, we show that homozygous mutant mice expressing p53 D31 , a p53 lacking the C-terminal domain, exhibit increas
Autor:
Elodie Dardillac, Alain Nicolas, Bernard S. Lopez, Gaël A. Millot, Graça Raposo-Benedetti, Maryse Romao, Lou Fourriere, Barbara Ben Yamin, Xavier Heiligenstein, Pierre Thouvenot, Aurianne Lescure, Jean-Baptiste Boulé, Vincent Lejour
Publikováno v:
Journal of Cell Science
Journal of Cell Science, 2016, ⟨10.1242/jcs.192880⟩
Journal of Cell Science, Company of Biologists, 2016, ⟨10.1242/jcs.192880⟩
Journal of Cell Science, 2016, ⟨10.1242/jcs.192880⟩
Journal of Cell Science, Company of Biologists, 2016, ⟨10.1242/jcs.192880⟩
Understanding the effect of an ever-growing number of human variants detected by genome sequencing is a medical challenge. The yeast Saccharomyces cerevisiae model has held attention for its capacity to monitor the functional impact of missense mutat
Autor:
A Raveux, Sandrine Vandormael-Pournin, Sarah Beck-Cormier, M Le Bouteiller, L Jarzebowski, S Coqueran, Vincent Lejour, Franck Toledo, Sylvie Robine, Michel Cohen-Tannoudji, Aline Stedman
Publikováno v:
Cell Death and Differentiation
Cell Death and Differentiation, Nature Publishing Group, 2015, 22 (11), pp.1865-1876 ⟨10.1038/cdd.2015.57⟩
Cell Death and Differentiation, 2015, 22 (11), pp.1865-1876 ⟨10.1038/cdd.2015.57⟩
Cell Death and Differentiation, Nature Publishing Group, 2015, 22 (11), pp.1865-1876 ⟨10.1038/cdd.2015.57⟩
Cell Death and Differentiation, 2015, 22 (11), pp.1865-1876 ⟨10.1038/cdd.2015.57⟩
International audience; Ribosome biogenesis is an essential cellular process. Its impairment is associated with developmental defects and increased risk of cancer. The in vivo cellular responses to defective ribosome biogenesis and the underlying mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::146cf357d7c8eea95b6b22ce10137d59
https://hal.sorbonne-universite.fr/hal-01316466
https://hal.sorbonne-universite.fr/hal-01316466