Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Vincent L. Revil-Baudard"'
Publikováno v:
Synthesis.
An efficient synthesis of 4-mercapto-4-methylpentanoic acid, a fragment notably found in Antibody-Drug Conjugates (ADCs), is reported using an intermolecular radical transfer reaction as the pivotal step. The reported approach displays several advant
Publikováno v:
Helvetica Chimica Acta
Helvetica Chimica Acta, Wiley, 2021, 104 (9), pp.e2100106. ⟨10.1002/hlca.202100106⟩
Helvetica Chimica Acta, Wiley, 2021, 104 (9), pp.e2100106. ⟨10.1002/hlca.202100106⟩
International audience; S-(1-Acetoxycyclobut-1-yl)-O-ethyl dithiocarbonate (xanthate) 7 was found to add to electronically unbiased alkene and to certain heteroarenes. In the latter case, this corresponds to a variant of the Minisci reaction and allo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2922e60d1ef8f0e06bbef90c81e616c2
https://hal.archives-ouvertes.fr/hal-03416880/document
https://hal.archives-ouvertes.fr/hal-03416880/document
Publikováno v:
Organic Letters
Organic Letters, American Chemical Society, 2018, 20 (12), pp.3531-3535. ⟨10.1021/acs.orglett.8b01299⟩
Organic Letters, American Chemical Society, 2018, 20 (12), pp.3531-3535. ⟨10.1021/acs.orglett.8b01299⟩
International audience; The xanthate-mediated addition of tertiary alkyl radicals to heteroarenes enabled the easy functionalization of heteroaromatic rings as well as more decorated structures, such as marketed drugs or agrochemicals. This work prov
Publikováno v:
Organic Letters
Organic Letters, American Chemical Society, 2019, 21 (16), pp.6352-6356. ⟨10.1021/acs.orglett.9b02237⟩
Organic Letters, American Chemical Society, 2019, 21 (16), pp.6352-6356. ⟨10.1021/acs.orglett.9b02237⟩
O-Neopentyl-xanthate 19 bearing a masked α-amino aldehyde, with the two functional groups orthogonally protected, reacts cleanly with many functional alkenes. The radical addition–transfer furnishes densely functionalized adducts that can be furth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea102813127fcdedb13471166436e3ff
https://hal.archives-ouvertes.fr/hal-02413722
https://hal.archives-ouvertes.fr/hal-02413722