Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Vincent L. Cryns"'
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114119- (2024)
Summary: Phosphatidylinositol 3-kinase α (PI3Kα) is a heterodimer of p110α catalytic and p85 adaptor subunits that is activated by agonist-stimulated receptor tyrosine kinases. Although p85α recruits p110α to activated receptors on membranes, p8
Externí odkaz:
https://doaj.org/article/ba50eb9bf1ea422fbc65f7e0f8dd4809
Autor:
Yifan Lu, Ali Hajjar, Vincent L. Cryns, Amy Trentham‐Dietz, Ronald E. Gangnon, Brandy M. Heckman‐Stoddard, Oguzhan Alagoz
Publikováno v:
Cancer Medicine, Vol 12, Iss 10, Pp 11703-11718 (2023)
Abstract Background Diabetes mellitus has been associated with increased breast cancer (BC) risk; however, the magnitude of this effect is uncertain. This study focused on BC risk for women with type 2 diabetes mellitus (T2DM). Methods Two separate m
Externí odkaz:
https://doaj.org/article/05ec6330400c4aa4ae9fb75302950c00
Publikováno v:
Biomolecules, Vol 13, Iss 10, p 1430 (2023)
The capacity for cancer cells to metastasize to distant organs depends on their ability to execute the carefully choreographed processes of cell adhesion and migration. As most human cancers are of epithelial origin (carcinoma), the transcriptional d
Externí odkaz:
https://doaj.org/article/d81d4d63c839450889705b76efbada8d
Publikováno v:
Biomolecules, Vol 13, Iss 9, p 1297 (2023)
Cytoplasmic phosphoinositides (PI) are critical regulators of the membrane–cytosol interface that control a myriad of cellular functions despite their low abundance among phospholipids. The metabolic cycle that generates different PI species is cru
Externí odkaz:
https://doaj.org/article/d7c03967a5dc46f58ebecafc5374fb22
Publikováno v:
Genomics Data, Vol 9, Iss C, Pp 10-17 (2016)
Emerging evidence suggests molecular chaperones have a role in the pathogenesis of obesity and diabetes. As αB-crystallin and HspB2 are molecular chaperones and data suggests their expression is elevated in the skeletal muscle of diabetic and obese
Externí odkaz:
https://doaj.org/article/2a4cbeb0754c41c28803c681c40a9079
Autor:
Mo Chen, Suyong Choi, Tianmu Wen, Changliang Chen, Narendra Thapa, Jeong Hyo Lee, Vincent L. Cryns, Richard A. Anderson
Publikováno v:
Nat Cell Biol
The tumor suppressor p53 and phosphoinositide 3-kinase (PI3K)-Akt pathway have fundamental roles in regulating cell growth and apoptosis, and they are frequently mutated in cancer. Here, we show that genotoxic stress induces nuclear Akt activation by
Publikováno v:
bioRxiv
SummaryThe membrane-localized phosphatidylinositol (PI) 3-kinase (PI3K)/Akt pathway regulates cell growth and is aberrantly activated in cancer. Recent studies reveal a distinct nuclear PI3K/Akt pathway involving PI phosphate (PIP) kinases that bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::648d91e780e33ec60825bd0fd06c7e23
https://europepmc.org/articles/PMC10197520/
https://europepmc.org/articles/PMC10197520/
Autor:
David F. Jarrard, Vincent L. Cryns, Kyle A. Richards, Dmitry Malin, Tyler Etheridge, Joseph Gawdzik, Adam Schultz, Mikolaj J. Filon, Tariq A. Khemees, Shivashankar Damodaran, Bing Yang
The initiation of androgen-deprivation therapy (ADT) induces susceptibilities in prostate cancer cells that make them vulnerable to synergistic treatment and enhanced cell death. Senescence results in cell-cycle arrest, but cells remain viable. In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02a68edb553efee842491ff4568a7673
https://doi.org/10.1158/1535-7163.c.6542298
https://doi.org/10.1158/1535-7163.c.6542298
Autor:
David F. Jarrard, Vincent L. Cryns, Kyle A. Richards, Dmitry Malin, Tyler Etheridge, Joseph Gawdzik, Adam Schultz, Mikolaj J. Filon, Tariq A. Khemees, Shivashankar Damodaran, Bing Yang
All supplementary table
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::273a894f38ad61b04579a09f61ce5d28
https://doi.org/10.1158/1535-7163.22519107
https://doi.org/10.1158/1535-7163.22519107
Supplementary Figure S2. Methioninase sensitizes TNBC cells to lexatumumab.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14cd40234d4282c294a95e66a2ad356a
https://doi.org/10.1158/1078-0432.22461236
https://doi.org/10.1158/1078-0432.22461236