Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Vincent L G, Postis"'
Autor:
Anna J. Higgins, Alex J. Flynn, Anaïs Marconnet, Laura J. Musgrove, Vincent L. G. Postis, Jonathan D. Lippiat, Chun-wa Chung, Tom Ceska, Manuela Zoonens, Frank Sobott, Stephen P. Muench
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Higgins et al. present a cycloalkane-modified amphiphilic polymer that can provide direct extraction of membrane proteins for Cryo-EM analysis. They show its utility by extracting and solving the structure of AcrB to a high resolution of 3.2 Å by si
Externí odkaz:
https://doaj.org/article/1c131cd75303428686e3487d6389ace3
Autor:
Anna J. Higgins, Alex J. Flynn, Anaïs Marconnet, Laura J. Musgrove, Vincent L. G. Postis, Jonathan D. Lippiat, Chun-wa Chung, Tom Ceska, Manuela Zoonens, Frank Sobott, Stephen P. Muench
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/5142b65377bf4a42b39f0f8fc99d749a
Autor:
Matthias Gantner, Theodoros Laftsoglou, Honglin Rong, Vincent L. G. Postis, Lars J. C. Jeuken
Publikováno v:
Membranes, Vol 10, Iss 10, p 255 (2020)
Transition metals are essential trace elements and their high-affinity uptake is required for many organisms. Metal transporters are often characterised using metal-sensitive fluorescent dyes, limiting the metals and experimental conditions that can
Externí odkaz:
https://doaj.org/article/99fe156a12b241ea8237dbd4b57d4ac8
Autor:
Rachel M. Johnson, Chiara Fais, Mayuriben Parmar, Harish Cheruvara, Robert L. Marshall, Sophie J. Hesketh, Matthew C. Feasey, Paolo Ruggerone, Attilio V. Vargiu, Vincent L. G. Postis, Stephen P. Muench, Vassiliy N. Bavro
Publikováno v:
Microorganisms, Vol 8, Iss 6, p 943 (2020)
Salmonella is an important genus of Gram-negative pathogens, treatment of which has become problematic due to increases in antimicrobial resistance. This is partly attributable to the overexpression of tripartite efflux pumps, particularly the consti
Externí odkaz:
https://doaj.org/article/06c3c346f1854ed9a49df0db156bb0da
Autor:
Robert Kolodziejczyk, Kornelia M Mikula, Tommi Kotila, Vincent L G Postis, T Sakari Jokiranta, Adrian Goldman, Taru Meri
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0188127 (2017)
Complement is an important part of innate immunity. The alternative pathway of complement is activated when the main opsonin, C3b coats non-protected surfaces leading to opsonisation, phagocytosis and cell lysis. The alternative pathway is tightly co
Externí odkaz:
https://doaj.org/article/edfce245bbc5411c85a413b7561c3500
Autor:
Cheng Ma, Zhenyu Hao, Gerard Huysmans, Amelia Lesiuk, Per Bullough, Yingying Wang, Mark Bartlam, Simon E Phillips, James D Young, Adrian Goldman, Stephen A Baldwin, Vincent L G Postis
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143010 (2015)
Membrane proteins play key roles in many biological processes, from acquisition of nutrients to neurotransmission, and are targets for more than 50% of current therapeutic drugs. However, their investigation is hampered by difficulties in their produ
Externí odkaz:
https://doaj.org/article/fa985a08272145f0adf146061e7bf582
Publikováno v:
Biochemical Society Transactions. 47:1197-1207
Glutamate transporters play important roles in bacteria, archaea and eukaryotes. Their function in the mammalian central nervous system is essential for preventing excitotoxicity, and their dysregulation is implicated in many diseases, such as epilep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf5b94534d255165995dbcfa34ea151
https://doi.org/10.1042/bst20190316
https://doi.org/10.1042/bst20190316
Autor:
Yixin, Liu, Ana, Pavić, Joshua T, Farley, Carine, de Marcos Lousa, Adrian, Goldman, Vincent L G, Postis
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2168
A major obstacle to studying membrane proteins by biophysical techniques is the difficulty in producing sufficient amounts of materials for functional and structural studies. To overexpress the target membrane protein heterologously, especially an eu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e7578b8a4c7a4d66992d394b9b1837a1
https://pubmed.ncbi.nlm.nih.gov/33582985
https://pubmed.ncbi.nlm.nih.gov/33582985
Autor:
Ana Pavić, Vincent L. G. Postis, Agnese Serafini, Mark Bartlam, Martin J. McPhillie, Alexandra O. M. Holmes, Yingying Wang, Luiz Pedro S. de Carvalho, Acely Garza-Garcia, Adrian Goldman, Yurui Ji
Publikováno v:
Journal of Bacteriology. 203
Characterizing the mycobacterial transporters involved in the uptake and/or catabolism of host-derived nutrients required by mycobacteria may identify novel drug targets against tuberculosis. Here, we identify and characterize a member of the amino a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f49b9ac0c69d66b7b08a65e1d7a031fb
https://doi.org/10.1128/jb.00642-20
https://doi.org/10.1128/jb.00642-20
Autor:
Frank Sobott, Laura J. Musgrove, Anna J. Higgins, Chun-wa Chung, Alex J. Flynn, Stephen P. Muench, Tom Ceska, Jonathan D. Lippiat, Manuela Zoonens, Anaïs Marconnet, Vincent L. G. Postis
Membrane proteins are essential for cellular growth, signalling and homeostasis, making up a large proportion of therapeutic targets. However, the necessity for a solubilising agent to extract them from the membrane creates challenges in their struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17aee626adaa24e1c6e4bda7be361131
https://doi.org/10.21203/rs.3.rs-131488/v1
https://doi.org/10.21203/rs.3.rs-131488/v1
