Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Vincent Jannin"'
Autor:
Michael Grimm, Adrian Rump, Marie-Luise Kromrey, Felix Morof, Camille Dumont, Vincent Jannin, Mladen Vassilev Tzvetkov, Werner Weitschies
Publikováno v:
Pharmaceutics, Vol 15, Iss 11, p 2576 (2023)
Ready-to-fill enteric hard capsule shells are an evolving field of oral drug and nutraceutical products. Lonza Capsugel® Enprotect® capsules were recently proven to provide reliable release in the small intestine after fasted intake, but robustness
Externí odkaz:
https://doaj.org/article/b17e1b020db1404c97cfa1b56c1ea7ce
Autor:
Adrian Rump, Marie-Luise Kromrey, Eberhard Scheuch, Vincent Jannin, Lara Rehenbrock, Mladen Vassilev Tzvetkov, Werner Weitschies, Michael Grimm
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 1999 (2022)
Many orally dosed APIs are bioavailable only when formulated as an enteric dosage form to protect them from the harsh environment of the stomach. However, an enteric formulation is often accompanied with a higher development effort in the first place
Externí odkaz:
https://doaj.org/article/6a9c42fae777422f8cc17f5817e3fe94
Autor:
Adrian Rump, Franziska N. Weiss, Louisa Schulz, Marie-Luise Kromrey, Eberhard Scheuch, Mladen V. Tzvetkov, Tyler White, Shane Durkee, Kevin W. Judge, Vincent Jannin, Aouatef Bellamine, Werner Weitschies, Michael Grimm
Publikováno v:
Pharmaceutics, Vol 13, Iss 12, p 2002 (2021)
Controlling the time point and site of the release of active ingredients within the gastrointestinal tract after administration of oral delivery systems is still a challenge. In this study, the effect of the combination of small capsules (size 3) and
Externí odkaz:
https://doaj.org/article/23bb7f9e40bd4f1ca17bc2316b3eb792
Publikováno v:
Oral Drug Delivery for Modified Release Formulations. :205-213
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12fdb8a3f07558ce3725b6569e482dd2
https://doi.org/10.1002/9781119772729.ch11
https://doi.org/10.1002/9781119772729.ch11
Autor:
Colin W. Pouton, Shadabul Haque, Endri Kastrati, Vincent Jannin, Mitchell P. McInerney, David K. Chalmers, Karen M. Corbett, Christopher J.H. Porter, Leigh Ford, Hassan Benameur, Hywel David Williams, Dallas B. Warren
Publikováno v:
Pharmaceutical Research. 38:1531-1547
Molecular dynamics (MD) simulations provide an in silico method to study the structure of lipid-based formulations (LBFs) and the incorporation of poorly water-soluble drugs within such formulations. In order to validate the ability of MD to effectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0808af6cfd8a6e523d490d015ec480b6
https://doi.org/10.1007/s11095-021-03099-5
https://doi.org/10.1007/s11095-021-03099-5
Autor:
Philip E. Thompson, Hywel David Williams, Peter J. Scammells, Shadabul Haque, Mitchell P. McInerney, Peng Li, Hassan Benameur, Vincent Jannin, Christopher J.H. Porter, Colin W. Pouton, Leigh Ford
Publikováno v:
Pharmaceutical Research. 38:1125-1137
Successful oral peptide delivery faces two major hurdles: low enzymatic stability in the gastro-intestinal lumen and poor intestinal membrane permeability. While lipid-based formulations (LBF) have the potential to overcome these barriers, effective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b12d9de7c2a9f94d3ad127d5c492292
https://doi.org/10.1007/s11095-021-03063-3
https://doi.org/10.1007/s11095-021-03063-3
Autor:
Vincent Jannin, Cindy Duysburgh, Vanessa Gonzalez, Marlies Govaert, Marine Agisson, Massimo Marzorati, Nicolas Madit
Publikováno v:
International Journal of Pharmaceutics. 630:122441
The dissolution characteristics of five capsules (Next Generation Enteric [NGE], Vcaps® Enteric [VCE], VCE DUOCAP® [VCE/VCE] system, Hard Gelatin Capsule [HGC] as negative control, and Creon® 10,000 U as market reference) were evaluated using an i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::657527c348995641d1a44bf54dee2c69
https://doi.org/10.1016/j.ijpharm.2022.122441
https://doi.org/10.1016/j.ijpharm.2022.122441
Autor:
Colin W. Pouton, Amali G. Guruge, David K. Chalmers, Dallas B. Warren, Hywel David Williams, Vincent Jannin, Hassan Benameur, Leigh Ford
Publikováno v:
Molecular pharmaceutics. 18(12)
Type III lipid-based formulations (LBFs) combine poorly water-soluble drugs with oils, surfactants, and cosolvents to deliver the drugs into the systemic circulation. However, the solubility of the drug can be influenced by the colloidal phases forme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e60a711d2e0f31d059c5a5f6fd9dd26
https://pubmed.ncbi.nlm.nih.gov/34807627
https://pubmed.ncbi.nlm.nih.gov/34807627
Autor:
Werner Weitschies, Aouatef Bellamine, Adrian Rump, Tyler White, Mladen V. Tzvetkov, Franziska N. Weiss, Shane Durkee, Kevin W. Judge, Michael Grimm, Vincent Jannin, Louisa Schulz, Eberhard Scheuch, Marie-Luise Kromrey
Publikováno v:
Pharmaceutics, Vol 13, Iss 2002, p 2002 (2021)
Pharmaceutics
Pharmaceutics; Volume 13; Issue 12; Pages: 2002
Pharmaceutics
Pharmaceutics; Volume 13; Issue 12; Pages: 2002
Controlling the time point and site of the release of active ingredients within the gastrointestinal tract after administration of oral delivery systems is still a challenge. In this study, the effect of the combination of small capsules (size 3) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::087f5dd7ea128a4763665ed5a50e1fcc
https://www.mdpi.com/1999-4923/13/12/2002
https://www.mdpi.com/1999-4923/13/12/2002
Autor:
Vincent Jannin, Fiona McCartney, Cédric Miolane, Nicolas Ritter, Frédéric Demarne, Delyan R. Hristov, Hakime Boulghobra, David J. Brayden, Yann Chavant, Stéphanie Chevrier
Publikováno v:
Journal of Controlled Release. 310:115-126
Labrasol® ALF (Labrasol®), is a non-ionic surfactant excipient primarily used as a solubilising agent. It was investigated here as an intestinal permeation enhancer in isolated rat colonic mucosae in Ussing chamber and in rat in situ intestinal ins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::822bd424debef6c700927a888beff363
https://doi.org/10.1016/j.jconrel.2019.08.008
https://doi.org/10.1016/j.jconrel.2019.08.008