Výsledky vyhledávání - "Vincent J.A. Bourgonje"

The electromechanical window is no better than QT prolongation to assess risk of T orsade de P ointes in the complete atrioventricular block model in dogs

Autor: H D M Beekman, M A Vos, Marieke Schoenmakers, Peter Oosterhoff, J M van Opstal, T. R. G. Stams, R. van der Nagel, Vincent J.A. Bourgonje

Publikováno v: British Journal of Pharmacology. 171:714-722

Background and Purpose The electromechanical window (EMW), the interval between the end of the T-wave and the end of the left ventricular pressure (LVP) curve, has recently been proposed as a predictor of risk of Torsade de Pointes (TdP) in healthy a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c35813f26013c7d0ef2fd45f35752765
https://doi.org/10.1111/bph.12483

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Combined Na + /Ca 2+ Exchanger and L-Type Calcium Channel Block as a Potential Strategy to Suppress Arrhythmias and Maintain Ventricular Function

Autor: Erik Rauch, Károly Acsai, Nicolas Doisne, Karin R. Sipido, Lars Kattner, Toon A.B. van Veen, András Varró, Marc A. Vos, Jet D.M. Beekman, István Zupkó, Anita Sztojkov-Ivanov, Vincent J.A. Bourgonje, Marien J C Houtman, Roel van der Nagel, Virginie Bito, Gudrun Antoons, Semir Ozdemir

Publikováno v: Circulation: Arrhythmia and Electrophysiology; Vol 6

Background— L-type calcium channel (LTCC) and Na + /Ca 2+ exchanger (NCX) have been implicated in repolarization-dependent arrhythmias, but also modulate calcium and contractility. Although LTCC inhibition is negative inotropic, NCX inhibition has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac7d346d5f148ac6f80d7e075507f8ed
https://doi.org/10.1161/circep.113.000322

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Verapamil as an antiarrhythmic agent in congestive heart failure: hopping from rabbit to human?

Autor: Marc A. Vos, Vincent J.A. Bourgonje, Thom R G Stams, Marcel A.G. van der Heyden

Publikováno v: British Journal of Pharmacology; Vol 166
British Journal of Pharmacology

In cardiac ventricular myocytes, an imbalance between inward and outward currents may prolong action potential duration. This makes the heart vulnerable to the occurrence of so-called torsade de pointes (TdP) arrhythmias, which are life-threatening v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b114972c3780eb08f5934eb7ff9fffb

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New antiarrhythmic targets to control intracellular calcium handling

Autor: Vincent J.A. Bourgonje, M A Vos, H. E. Driessen, T. A. B. van Veen

Publikováno v: Netherlands Heart Journal

Sudden cardiac death due to ventricular arrhythmias is a major problem. Drug therapies to prevent SCD do not provide satisfying results, leading to the demand for new antiarrhythmic strategies. New targets include Ca(2+)/Calmodulin-dependent protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36e54b17ceb330d6682d12f77bfe0b1e
https://pubmed.ncbi.nlm.nih.gov/24733689

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Ventricular Electrical Remodeling in Compensated Cardiac Hypertrophy

Autor: Vincent J.A. Bourgonje, Marc A. Vos, Toon A.B. van Veen

Publikováno v: Electrical Diseases of the Heart ISBN: 9781447148807

Ventricular hypertrophy (VH) is a structural adaptation of the heart that develops in response to either congenital or acquired pathologies to reduce wall stress.1 Dominant etiologies are genetic mutations (e.g., in sarcomeric proteins),2 ischemic di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24b61cfe757cc40e8bb9c3a0cf11322c
https://doi.org/10.1007/978-1-4471-4881-4_23

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The electromechanical window: Not superior to QT as a surrogate parameter for risk of dofetilide-induced Torsade de Pointes in the anesthetized canine complete atrioventricular block model

Autor: Marieke Schoenmakers, Peter Oosterhoff, Vincent J.A. Bourgonje, Roel van der Nagel, Jurren M. van Opstal, Marc A. Vos, Jet D.M. Beekman, Thom R G Stams

Publikováno v: Journal of Pharmacological and Toxicological Methods. 70:345-346

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb2fa26bc3352d7364a7d53e4af4e417
https://doi.org/10.1016/j.vascn.2014.03.125

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P630Calmodulin/CaMKII inhibition accelerates conduction velocity by augmenting the localization of Cx43 in the intercalated disk

Autor: Hiroki Takanari, Fontes, Marcel A.G. van der Heyden, H. E. Driessen, Hvm Van Rijen, A. van der Veen, Mag Vos, Haj Raaijmakers, Vincent J.A. Bourgonje, I Kodama

Publikováno v: Cardiovascular Research. 103:S114.3-S114

Purpose: In healthy hearts, ventricular gap junctions are composed by Connexin43 proteins (Cx43) and are localized in the intercalated disk (ID) where they enable appropriate electrical and metabolic coupling. During pathophysiological conditions, Cx

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3dda0c93faba8710745238c1bdd325d1
https://doi.org/10.1093/cvr/cvu098.57

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Discrepancy Between Acute and Long-Term Effects of the Calmodulin-Camkii-Calcineurin Pathway on Arrhythmogenesis in the CAVB Dog

Autor: Roel van der Nagel, Leon J. De Windt, Marc A. Vos, Jet D.M. Beekman, Vincent J.A. Bourgonje, Toon A.B. van Veen, Marieke Schoenmakers

Publikováno v: Heart Rhythm. 6:1693-1694

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b3f4a9bf866590847c313813e47b662
https://doi.org/10.1016/j.hrthm.2009.09.055

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