Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Vincent J. Kalish"'
Autor:
Kevin J. Tomaselli, Julia Herrmann, Robert O. Sayers, Joe C. Wu, Lalitha Kodandapani, Kathy G. Jahangiri, Craig D. Fisher, David T. Winn, Edward D. Robinson, Steven P. Meduna, Robert J. Ternansky, Pauline Yeo, Karen L. Valentino, Jose-Luis Diaz, Vincent J. Kalish, Steven D. Linton, Kristen Sebring, Robert A. Armstrong, Joseph F. Krebs, Niel C. Hoglen, Alfred P. Spada, Brad P. Hirakawa, Ning Chen, Brett R. Ullman, Brett Weylan Ching, Cheng-zhi Zhang, Xu Bai, Xin Gu, Kip Nalley, Long-Shiuh Chen, Patricia L. Gladstone, Jeff McQuiston, Teresa Aja, Todd Groessl, Donald S. Karanewsky, Suzanne Weeks, Lawrence C. Fritz, Patricia C. Contreras
Publikováno v:
Journal of Medicinal Chemistry. 48:6779-6782
A series of oxamyl dipeptides were optimized for pan caspase inhibition, anti-apoptotic cellular activity and in vivo efficacy. This structure-activity relationship study focused on the P4 oxamides and warhead moieties. Primarily on the basis of in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc05f6b9f812322c1ff557485178cfdb
https://doi.org/10.1021/jm050307e
https://doi.org/10.1021/jm050307e
Autor:
Edward D. Robinson, Silvio Roggo, Joe C. Wu, Robert J. Ternansky, Jose-Luis Diaz, Teresa Aja, Kevin J. Tomaselli, Steven P. Meduna, Vincent J. Kalish, Donald S. Karanewsky, Robert O. Sayers, Albert Schmitz, Brett R. Ullman, Julia Herrmann, Kip Nalley, Thomas L. Deckwerth
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:3623-3626
Various aryloxy methyl ketones of the 1-naphthyloxyacetyl-Val-Asp backbone have been prepared. A systematic study of their structure-activity relationship (SAR) related to caspases 1, 3, 6, and 8 is reported. Highly potent irreversible broad-spectrum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681ec055be84e31c81b8947185e1442d
https://doi.org/10.1016/s0960-894x(03)00755-8
https://doi.org/10.1016/s0960-894x(03)00755-8
Autor:
S. D. Hatch, Mark A. Muesing, Deborah A. Khalil, Nickolay Y. Chirgadze, Siegfried H. Reich, Vincent J. Kalish, Kenneth S. Su, Jeffrey A. Burgess, Krzysztof Appelt, Bruce A. Dressman, Penny P. Lubbehusen, Stephen W. Kaldor, Bhasker V. Shetty, Kristina M. Campanale, Jay F. Davies, David K. Clawson, John H. Tatlock, Maha B. Kosa, James E. Fritz, Amy K. Patick
Publikováno v:
Journal of Medicinal Chemistry. 40:3979-3985
Using a combination of iterative structure-based design and an analysis of oral pharmacokinetics and antiviral activity, AG1343 (Viracept, nelfinavir mesylate), a nonpeptidic inhibitor of HIV-1 protease, was identified. AG1343 is a potent enzyme inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a5e189e8078b8e21586a61aa6a6a51
https://doi.org/10.1021/jm9704098
https://doi.org/10.1021/jm9704098
Autor:
J. V. French, Richard E. Showalter, Hans E. Parge, Vincent J. Kalish, Daniel R. Knighton, John H. Tatlock, Christina T. Lewis, J. Ernest Villafranca
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2489-2494
The preparation and evaluation of potent small molecule inhibitors of FKBP-12 rotamase activity is described. These ligands contain many of the structural features of the FK506 pyranose ring region, yet are synthetically more accessible. The versatil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21ce686745ca70ec16a529ff6519260e
https://doi.org/10.1016/0960-894x(95)00429-w
https://doi.org/10.1016/0960-894x(95)00429-w
Autor:
Vincent J. Kalish, Krzysztof Appelt, Jay F. Davies, Mark J. Pino, B.‐W. Wu, Stephen W. Kaldor, Dzuy Nyugen, L. Musick, Bruce A. Dressman, John H. Tatlock, Reich Siegfried Heinz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:727-732
The cocrystal structures of LY289612 and LY297135 were used as a starting point in the design of nonpeptidic HIV-1 protease inhibitors. This report details the discovery of a series of novel aromatic P 2 replacement groups. The 3-hydroxy-2-methyl ben
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a562555c8de1485992b95539a7e10dc
https://doi.org/10.1016/0960-894x(95)00103-z
https://doi.org/10.1016/0960-894x(95)00103-z
Autor:
Kevin A. Babiak, Vincent J. Kalish, Robert L. Shone, John H. Dygos, Mclaughlin Kathleen T, James R. Behling, John S. Ng, Steven W. Kramer
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b3077f274ffe1c7b1a2c4e0ac628496
https://doi.org/10.1002/chin.199103338
https://doi.org/10.1002/chin.199103338
Autor:
R. E. Showalter, Vincent J. Kalish, John H. Tatlock, Jesus Ernesto Villafranca, J. V. French, Daniel R. Knighton, Hans E. Parge, C. T. Lewis
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22311a1e3908ad348fac43c9659a3cb6
https://doi.org/10.1002/chin.199609313
https://doi.org/10.1002/chin.199609313
Autor:
Vincent J. Kalish, Tays Kevin L, Larisa Serdyuk, Ge Xiao, Jie Zhang, Dana Ferraris, Susan Lautar, Weixing Li, Jia-He Li, Paul W. Kletzly
Publikováno v:
ChemInform. 32
1-, 2-, 3-, 4-, 8-, or 10-Substituted 5(H)phenanthridin-6-ones were synthesized and found to be potent PARP1 inhibitors. Among the 28 compounds prepared, some showed not only low IC50 values (compound 1b, 10 nM) but also desirable water solubility ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f841f1b4919419ec9ff83df6588d8801
https://doi.org/10.1002/chin.200147122
https://doi.org/10.1002/chin.200147122
Publikováno v:
The Journal of Organic Chemistry. 55:105-111
La methode presentee s'effectue a partir du bromo-2 ethylenedioxy-3 norbornanecarboxylate-7 de methyle; elle conduit uniquement au dihydro-4a,7a methoxy-1 cyclopenta [c] pyrannedicarboxylate-3,5 de methyle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::582043a4214f08ff2d29315e430de3eb
https://doi.org/10.1021/jo00288a022
https://doi.org/10.1021/jo00288a022
Publikováno v:
Tetrahedron. 46:8067-8074
The carbon framework for carbapenems was constructed by an asymmetric aldol condensation and subsequent direct coupling of the resulting β-hydroxy acid equivalent with an aminophosphonoacetate. Cyclization to the monocyclic β-lactam 20 was followed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b779a2ee9ac891c67a9d65afca80fcd
https://doi.org/10.1016/s0040-4020(01)81463-0
https://doi.org/10.1016/s0040-4020(01)81463-0