An EMT–primary cilium–GLIS2 signaling axis regulates mammogenesis and claudin-low breast tumorigenesis

Autor: Vincent J Guen, Jane E. Visvader, Qiong Ding, Philippe Juin, Matthieu Le Gallo, Anton M. Jetten, Tony E. Chavarria, Claude Prigent, Sophie G. Martin, Hong Soon Kang, Massimo Attanasio, Amandine Salamagnon, Patrick Tas, Arjun Bhutkar, Florence Godey, Roselyne Viel, Molly M. Wilson, Jacqueline A. Lees, Céline Callens, Svetlana Mironov, Robert A. Weinberg, Abena D. Peasah

Publikováno v: Science Advances
Science Advances, 2021, 7 (44), pp.eabf6063. ⟨10.1126/sciadv.abf6063⟩
Science Advances, American Association for the Advancement of Science (AAAS), 2021, 7 (44), pp.eabf6063. ⟨10.1126/sciadv.abf6063⟩

Description
EMT induces cilium assembly and signaling to promote mammogenesis and tumorigenesis.
The epithelial-mesenchymal transition (EMT) and primary ciliogenesis induce stem cell properties in basal mammary stem cells (MaSCs) to promote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d9cba2c2a810c37bda8a493b533d1dc
https://doi.org/10.1126/sciadv.abf6063

Three-Dimensional Imaging of Organoids to Study Primary Ciliogenesis During ex vivo Organogenesis

Autor: Vincent J. Guen, Roland Le Borgne, Claude Prigent, Maela Duclos

Publikováno v: Journal of Visualized Experiments.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b4e9fbe45c4143dcc603b46c85eccfd0
https://doi.org/10.3791/62365-v

Emerging Mechanisms by which EMT Programs Control Stemness

Autor: Molly M. Wilson, Jacqueline A. Lees, Robert A. Weinberg, Vincent J. Guen

Publikováno v: Trends in Cancer
Trends in Cancer, 2020, 6 (9), pp.775-780. ⟨10.1016/j.trecan.2020.03.011⟩
Trends in Cancer, Cell Press, 2020, 6 (9), pp.775-780. ⟨10.1016/j.trecan.2020.03.011⟩

International audience; Tissue regeneration relies on adult stem cells (SCs) that possess the ability to self-renew and produce differentiating progeny. In an analogous manner, the development of certain cancers depends on a subset of tumor cells, ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0708dc97f6afd6d7582638d299057030
https://univ-rennes.hal.science/hal-02565570/document

E2F4’s cytoplasmic role in multiciliogenesis is mediated via an N-terminal domain that binds two components of the centriole replication machinery, Deup1 and SAS6

Autor: Wellington V. Cardoso, Vincent J Guen, Paul S. Danielian, Renin Hazan, Seth M. Rubin, Jacqueline A. Lees, Munemasa Mori

Publikováno v: Molecular Biology of the Cell

Multiciliated cells play critical roles in the airway, reproductive organs, and brain. Generation of multiple cilia requires both activation of a specialized transcriptional program and subsequent massive amplification of centrioles within the cytopl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c4b3e28bc82a14acb833e5effe29ae1
https://doi.org/10.1091/mbc.e21-01-0039

CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome

Autor: Pierre Colas, Marc Flajolet, Yoan Ferandin, Andrea Superti-Furga, Laurent Meijer, Sheila Unger, Aurélie Thollet, Pascale A. Cohen, Carly Gamble, Vincent J Guen

Publikováno v: Proceedings of the National Academy of Sciences. 110:19525-19530

Cyclin-dependent kinases (CDKs) regulate a variety of fundamental cellular processes. CDK10 stands out as one of the last orphan CDKs for which no activating cyclin has been identified and no kinase activity revealed. Previous work has shown that CDK

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40ae811dcff0559ee8782d7eec6d4381
https://doi.org/10.1073/pnas.1306814110