Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Vincent J J Martin"'
Autor:
Yu Zhan, Christophe H Marchand, Alexandre Maes, Adeline Mauries, Yi Sun, James S Dhaliwal, James Uniacke, Simon Arragain, Heng Jiang, Nicholas D Gold, Vincent J J Martin, Stéphane D Lemaire, William Zerges
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0185039 (2018)
Organelles are intracellular compartments which are themselves compartmentalized. Biogenic and metabolic processes are localized to specialized domains or microcompartments to enhance their efficiency and suppress deleterious side reactions. An examp
Externí odkaz:
https://doaj.org/article/6769398fc55a492fbbf2a4c02a9a5cc3
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124459 (2015)
Morphinan alkaloids are the most powerful narcotic analgesics currently used to treat moderate to severe and chronic pain. The feasibility of morphinan synthesis in recombinant Saccharomyces cerevisiae starting from the precursor (R,S)-norlaudanosoli
Externí odkaz:
https://doaj.org/article/e709d90b36094462b4cefd377e7a806f
Autor:
Michael E. Pyne, James A. Bagley, Lauren Narcross, Kaspar Kevvai, Kealan Exley, Meghan Davies, Qingzhao Wang, Malcolm Whiteway, Vincent J. J. Martin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Saccharomyces cerevisiae is a workhorse of industrial biotechnology owing to the organism’s prominence in alcohol fermentation and the suite of sophisticated genetic tools available to manipulate its metabolism. However, S. cerevisiae is n
Externí odkaz:
https://doaj.org/article/5ee80e772d7d43c7bc892ed4826582d3
Autor:
Björn D. M. Bean, Colleen J. Mulvihill, Riddhiman K. Garge, Daniel R. Boutz, Olivier Rousseau, Brendan M. Floyd, William Cheney, Elizabeth C. Gardner, Andrew D. Ellington, Edward M. Marcotte, Jimmy D. Gollihar, Malcolm Whiteway, Vincent J. J. Martin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The yeast Saccharomyces cerevisiae is powerful for studying human G protein-coupled receptors as they can be coupled to its mating pathway. Here the authors engineer baker’s yeast to produce human sterols and show that vertebrate G protein coupled
Externí odkaz:
https://doaj.org/article/9457c15ee6604fa583dda2078ebe4c7e
Publikováno v:
Open Biology, Vol 12, Iss 11 (2022)
Cytokinesis is required to physically separate the daughter cells at the end of mitosis. This crucial process requires the assembly and ingression of an actomyosin ring, which must occur with high fidelity to avoid aneuploidy and cell fate changes. M
Externí odkaz:
https://doaj.org/article/a3bf914b92fb4e19aebef83d58820bb8
Publikováno v:
Metabolic Engineering. 77:162-173
Sacred lotus (Nelumbo nucifera) has been utilized as a food, medicine, and spiritual symbol for nearly 3,000 years. The medicinal properties of lotus are largely attributed to its unique profile of benzylisoquinoline alkaloids (BIAs), which includes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e3c07ded1cf20c99fb0e181d88de6a
https://doi.org/10.1016/j.ymben.2023.03.010
https://doi.org/10.1016/j.ymben.2023.03.010
Autor:
Lauren Narcross, Michael E. Pyne, Kaspar Kevvai, Ka-Hei Siu, John E. Dueber, Vincent J. J. Martin
The benzylisoquinoline alkaloid (BIA) family of tetrahydroisoquinolines (THIQs) comprises over 2,500 members, including the pharmaceuticals morphine, codeine, and papaverine as well as the antibiotics sanguinarine and chelerythrine used in animal hus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92f6998ca3d3e8ce612be2b7976df778
https://doi.org/10.1101/2023.05.19.541502
https://doi.org/10.1101/2023.05.19.541502
Publikováno v:
Metabolites, Vol 11, Iss 3, p 147 (2021)
Paclitaxel is an important diterpenoid commonly used as an anticancer drug. Although the paclitaxel biosynthetic pathway has been mostly revealed, some steps remain to be elucidated. The difficulties in plant transformations and the scarcity of the p
Externí odkaz:
https://doaj.org/article/5b1ebbc7786546fe979f7e55f8b6be96
Publikováno v:
ACS Synthetic Biology. 11:1692-1698
Allosteric transcription factor (aTF) biosensors are valuable tools for engineering microbes toward a multitude of applications in metabolic engineering, biotechnology, and synthetic biology. One of the challenges toward constructing functional and d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf25aa6d1b8282302bc81b9e3fa84d17
https://doi.org/10.1021/acssynbio.2c00063
https://doi.org/10.1021/acssynbio.2c00063
Publikováno v:
ACS Synthetic Biology. 10:2896-2903
While nepetalactone, the active ingredient in catnip, is a potent insect repellent, its low in planta accumulation limits its commercial viability as an alternative repellent. Here we describe a platform for de novo nepetalactone production in Saccha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7313c6da174d0c95da46e2d3f032a5da
https://doi.org/10.1021/acssynbio.1c00420
https://doi.org/10.1021/acssynbio.1c00420