Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Vincent J J, Martin"'
Autor:
Michael E. Pyne, James A. Bagley, Lauren Narcross, Kaspar Kevvai, Kealan Exley, Meghan Davies, Qingzhao Wang, Malcolm Whiteway, Vincent J. J. Martin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Saccharomyces cerevisiae is a workhorse of industrial biotechnology owing to the organism’s prominence in alcohol fermentation and the suite of sophisticated genetic tools available to manipulate its metabolism. However, S. cerevisiae is n
Externí odkaz:
https://doaj.org/article/5ee80e772d7d43c7bc892ed4826582d3
Autor:
Björn D. M. Bean, Colleen J. Mulvihill, Riddhiman K. Garge, Daniel R. Boutz, Olivier Rousseau, Brendan M. Floyd, William Cheney, Elizabeth C. Gardner, Andrew D. Ellington, Edward M. Marcotte, Jimmy D. Gollihar, Malcolm Whiteway, Vincent J. J. Martin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The yeast Saccharomyces cerevisiae is powerful for studying human G protein-coupled receptors as they can be coupled to its mating pathway. Here the authors engineer baker’s yeast to produce human sterols and show that vertebrate G protein coupled
Externí odkaz:
https://doaj.org/article/9457c15ee6604fa583dda2078ebe4c7e
Publikováno v:
Open Biology, Vol 12, Iss 11 (2022)
Cytokinesis is required to physically separate the daughter cells at the end of mitosis. This crucial process requires the assembly and ingression of an actomyosin ring, which must occur with high fidelity to avoid aneuploidy and cell fate changes. M
Externí odkaz:
https://doaj.org/article/a3bf914b92fb4e19aebef83d58820bb8
Autor:
Michael E. Pyne, Kaspar Kevvai, Parbir S. Grewal, Lauren Narcross, Brian Choi, Leanne Bourgeois, John E. Dueber, Vincent J. J. Martin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Plants synthesize more than 3000 tetrahydroisoquinoline (THIQ) alkaloids, but only a few of them have been produced by engineered microbes and titers are very low. Here, the authors increase (S)-reticuline titer to 4.6 g/L and repurpose the yeast Ehr
Externí odkaz:
https://doaj.org/article/1711736c3c694987b81eeec5d825890d
Autor:
Nathan Hillson, Mark Caddick, Yizhi Cai, Jose A. Carrasco, Matthew Wook Chang, Natalie C. Curach, David J. Bell, Rosalind Le Feuvre, Douglas C. Friedman, Xiongfei Fu, Nicholas D. Gold, Markus J. Herrgård, Maciej B. Holowko, James R. Johnson, Richard A. Johnson, Jay D. Keasling, Richard I. Kitney, Akihiko Kondo, Chenli Liu, Vincent J. J. Martin, Filippo Menolascina, Chiaki Ogino, Nicola J. Patron, Marilene Pavan, Chueh Loo Poh, Isak S. Pretorius, Susan J. Rosser, Nigel S. Scrutton, Marko Storch, Hille Tekotte, Evelyn Travnik, Claudia E. Vickers, Wen Shan Yew, Yingjin Yuan, Huimin Zhao, Paul S. Freemont
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-4 (2019)
Biofoundries provide an integrated infrastructure to enable the rapid design, construction, and testing of genetically reprogrammed organisms for biotechnology applications and research. Many biofoundries are being built and a Global Biofoundry Allia
Externí odkaz:
https://doaj.org/article/de6edd0c40ef4b9a90ff2ae779879b15
Publikováno v:
Metabolic Engineering. 77:162-173
Sacred lotus (Nelumbo nucifera) has been utilized as a food, medicine, and spiritual symbol for nearly 3,000 years. The medicinal properties of lotus are largely attributed to its unique profile of benzylisoquinoline alkaloids (BIAs), which includes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e3c07ded1cf20c99fb0e181d88de6a
https://doi.org/10.1016/j.ymben.2023.03.010
https://doi.org/10.1016/j.ymben.2023.03.010
Publikováno v:
Biotechnology for Biofuels, Vol 11, Iss 1, Pp 1-16 (2018)
Abstract Background Genome shuffling (GS) is a widely adopted methodology for the evolutionary engineering of desirable traits in industrially relevant microorganisms. We have previously used genome shuffling to generate a strain of Saccharomyces cer
Externí odkaz:
https://doaj.org/article/be310f7bef8b493baad3523cf4a75ba2
Autor:
Lauren Narcross, Michael E. Pyne, Kaspar Kevvai, Ka-Hei Siu, John E. Dueber, Vincent J. J. Martin
The benzylisoquinoline alkaloid (BIA) family of tetrahydroisoquinolines (THIQs) comprises over 2,500 members, including the pharmaceuticals morphine, codeine, and papaverine as well as the antibiotics sanguinarine and chelerythrine used in animal hus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92f6998ca3d3e8ce612be2b7976df778
https://doi.org/10.1101/2023.05.19.541502
https://doi.org/10.1101/2023.05.19.541502
Publikováno v:
Metabolites, Vol 11, Iss 3, p 147 (2021)
Paclitaxel is an important diterpenoid commonly used as an anticancer drug. Although the paclitaxel biosynthetic pathway has been mostly revealed, some steps remain to be elucidated. The difficulties in plant transformations and the scarcity of the p
Externí odkaz:
https://doaj.org/article/5b1ebbc7786546fe979f7e55f8b6be96
Publikováno v:
ACS Synthetic Biology. 11:1692-1698
Allosteric transcription factor (aTF) biosensors are valuable tools for engineering microbes toward a multitude of applications in metabolic engineering, biotechnology, and synthetic biology. One of the challenges toward constructing functional and d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf25aa6d1b8282302bc81b9e3fa84d17
https://doi.org/10.1021/acssynbio.2c00063
https://doi.org/10.1021/acssynbio.2c00063