Ruthenium-based PACT agents based on bisquinoline chelates: synthesis, photochemistry, and cytotoxicity

Autor: Sylvestre Bonnet, Anja Busemann, Ingo Ott, Ingrid Flaspohler, Vincent H. S. van Rixel, Sina K Goetzfried, Xue-Quan Zhou, Maxime A. Siegler, Claudia Schmidt

Publikováno v: Journal of Biological Inorganic Chemistry
Journal of Biological Inorganic Chemistry, 26(6), 667-674. SPRINGER

The known ruthenium complex [Ru(tpy)(bpy)(Hmte)](PF6)2 ([1](PF6)2, where tpy = 2,2’:6’,2″-terpyridine, bpy = 2,2’-bipyridine, Hmte = 2-(methylthio)ethanol) is photosubstitutionally active but non-toxic to cancer cells even upon light irradiat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e1e68a430be955052aac8ec4ec5865a
https://doi.org/10.1007/s00775-021-01882-8

Induction of a Four‐Way Junction Structure in the DNA Palindromic Hexanucleotide 5′‐d(CGTACG)‐3′ by a Mononuclear Platinum Complex

Autor: Bianka Siewert, Samantha L. Hopkins, Maxime A. Siegler, Marta Ferraroni, Luigi Messori, Paola Gratteri, Anja Busemann, Francesco Papi, Corjan van de Griend, Mathijs F. Wissingh, Sylvestre Bonnet, Carla Bazzicalupi, Vincent H. S. van Rixel, Tiziano Marzo

Publikováno v: Angewandte Chemie (International Ed. in English)
Angewandte Chemie International Edition
'Angewandte Chemie International Edition ', vol: 58, pages: 9378-9382 (2019)
Angewandte Chemie, 131(28), 9478-9482
Angewandte Chemie International Edition, 58(28), 9378-9382. WILEY-V C H VERLAG GMBH

Four‐way junctions (4WJs) are supramolecular DNA assemblies comprising four interacting DNA strands that in biology are involved in DNA‐damage repair. In this study, a new mononuclear platinum(II) complex 1 was prepared that is capable of driving

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f28aade4f19929bec04d3d3cd01af7fc
http://europepmc.org/articles/PMC6618160

Controlling with light the interaction between trans-tetrapyridyl ruthenium complexes and an oligonucleotide

Autor: Maxime A. Siegler, Vincent H. S. van Rixel, Luigi Messori, Geri F. Moolenaar, Sylvestre Bonnet

Publikováno v: Dalton Transactions, 47(2), 507-516
Dalton Transactions

Three new trans-ruthenium(ii) complexes coordinated to tetrapyridyl ligands, namely [Ru(bapbpy)(dmso)Cl]Cl ([2]Cl), [Ru(bapbpy)(Hmte)2](PF6)2 ([3](PF6)2), and [Ru(biqbpy)(Hmte)2](PF6)2 ([4](PF6)2), were prepared as analogues of [Ru(biqbpy)(dmso)Cl]Cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::629a4464029a4c2857a60eedf941c0d2
https://doi.org/10.1039/c7dt03613b

Chemical Swarming: Depending on Concentration, an Amphiphilic Ruthenium Polypyridyl Complex Induces Cell Death via Two Different Mechanisms

Autor: Miriam J. B. Moester, Eva J. van Rooden, Sylvestre Bonnet, Maxime A. Siegler, Bianka Siewert, Freek Ariese, Samantha L. Hopkins, Vincent H. S. van Rixel

Publikováno v: CHEMISTRY-A EUROPEAN JOURNAL
Chemistry: A European Journal, 22(31), 10960-10968. Wiley-VCH Verlag
Siewert, B, van Rixel, V H S, van Rooden, E J, Hopkins, S L, Moester, M J B, Ariese, F, Siegler, M A & Bonnet, S 2016, ' Chemical Swarming: Depending on Concentration, an Amphiphilic Ruthenium Polypyridyl Complex Induces Cell Death via Two Different Mechanisms ', Chemistry: A European Journal, vol. 22, no. 31, pp. 10960-10968 . https://doi.org/10.1002/chem.201600927
CHEMISTRY-A EUROPEAN JOURNAL, 22(31), 10960-10968
Chemistry (Weinheim an Der Bergstrasse, Germany)

The crystal structure and in vitro cytotoxicity of the amphiphilic ruthenium complex [3](PF6 )2 are reported. Complex [3](PF6 )2 contains a Ru-S bond that is stable in the dark in cell-growing medium, but is photosensitive. Upon blue-light irradiatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9968c11336f30deff4e1cb6ceeda597e
https://hdl.handle.net/1887/44462

Identification of potent and selective glucosylceramide synthase inhibitors from a library of N-alkylated iminosugars

Autor: Arjan C. J. de Bruijn, Frithjof D. Godschalk, Marieke C. Guijt, Peter Hagens, Rolf G. Boot, Anneke Strijland, Amar B. T. Ghisaidoobe, Mark Wijzenbroek, Steven M. van't Hart, Gijs A. van der Marel, Eva Rogaar, Johannes M. F. G. Aerts, Wilma E. Donker-Koopman, Vincent H. S. van Rixel, Herman S. Overkleeft, Stijn B. Luitjens, Richard J. B. H. N. van den Berg, Jerre M. Halma, Pieter Bikker, Thor Zweegers

Publikováno v: ACS medicinal chemistry letters, 2(2), 119-123. American Chemical Society

Glucosylceramide synthase (GCS) is an important target for clinical drug development for the treatment of lysosomal storage disorders and a promising target for combating type 2 diabetes. Iminosugars are useful leads for the development of GCS inhibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fdef980a9afc1194d9b941d6bb0267d
https://doi.org/10.1021/ml100192b