Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Vincent H Gattone"'
Autor:
K J Kelly, Jizhong Zhang, Ling Han, Malgorzata Kamocka, Caroline Miller, Vincent H Gattone, Jesus H Dominguez
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0131677 (2015)
Autosomal recessive polycystic kidney disease is a truly catastrophic monogenetic disease, causing death and end stage renal disease in neonates and children. Using PCK female rats, an orthologous model of autosomal recessive polycystic kidney diseas
Externí odkaz:
https://doaj.org/article/08db763952dd4046bdc084ca6d4dfc49
Autor:
Sarika Tiwari, Scott Hudson, Vincent H Gattone, Caroline Miller, Ellen A G Chernoff, Teri L Belecky-Adams
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59306 (2013)
Ciliopathies lead to multiorgan pathologies that include renal cysts, deafness, obesity and retinal degeneration. Retinal photoreceptors have connecting cilia joining the inner and outer segment that are responsible for transport of molecules to deve
Externí odkaz:
https://doaj.org/article/a17b55a7275e4518b9b114d376fc4e30
Autor:
Brittney-Shea Herbert, Brenda R Grimes, Wei Min Xu, Michael Werner, Christopher Ward, Sandro Rossetti, Peter Harris, Elsa Bello-Reuss, Heather H Ward, Caroline Miller, Vincent H Gattone, Carrie L Phillips, Angela Wandinger-Ness, Robert L Bacallao
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55191 (2013)
Autosomal dominant polycystic kidney disease (ADPKD) is associated with a variety of cellular phenotypes in renal epithelial cells. Cystic epithelia are secretory as opposed to absorptive, have higher proliferation rates in cell culture and have some
Externí odkaz:
https://doaj.org/article/1affffd7c15345f98c11b62caccdf1ff
Autor:
Neal X Chen, Kraiwiporn Kiattisunthorn, Kalisha D O'Neill, Xianming Chen, Ranjani N Moorthi, Vincent H Gattone, Matthew R Allen, Sharon M Moe
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64558 (2013)
Patients with CKD have abnormal vascular remodeling that is a risk factor for cardiovascular disease. MicroRNAs (miRNAs) control mRNA expression intracellularly and are secreted into the circulation; three miRNAs (miR-125b, miR-145 and miR-155) are k
Externí odkaz:
https://doaj.org/article/0b91b4f04d784c3895ad577f5825d642
Autor:
Jacqueline G. Parchem, Keizo Kanasaki, Soo Bong Lee, Megumi Kanasaki, Joyce L. Yang, Yong Xu, Kadeshia M. Earl, Rachel A. Keuls, Vincent H. Gattone II, Raghu Kalluri
Publikováno v:
JCI Insight, Vol 6, Iss 2 (2021)
The pathogenesis of preeclampsia and other hypertensive disorders of pregnancy remains poorly defined despite the substantial burden of maternal and neonatal morbidity associated with these conditions. In particular, the role of genetic variants as d
Externí odkaz:
https://doaj.org/article/4cc45d65458148de82efd4874b160229
Autor:
Keizo Kanasaki, Raghu Kalluri, Yong Xu, Rachel A. Keuls, Kadeshia M. Earl, Jacqueline G. Parchem, Soo Bong Lee, Megumi Kanasaki, Vincent H. Gattone, Joyce L. Yang
Publikováno v:
JCI Insight
JCI Insight, Vol 6, Iss 2 (2021)
JCI Insight, Vol 6, Iss 2 (2021)
The pathogenesis of preeclampsia and other hypertensive disorders of pregnancy remains poorly defined despite the substantial burden of maternal and neonatal morbidity associated with these conditions. In particular, the role of genetic variants as d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51957f9abc09afd82de029429f649544
https://pubmed.ncbi.nlm.nih.gov/33301424
https://pubmed.ncbi.nlm.nih.gov/33301424
Autor:
Peter Carmeliet, Megumi Kanasaki, Raghu Kalluri, Vincent H. Gattone, Soo Bong Lee, Jerome F. Strauss, Yuki Hamano, Jacqueline G. Parchem, Valerie S. LeBleu, Keizo Kanasaki, Samuel Parry, Hikaru Sugimoto, Thomas F. McElrath, Karen H. Lu, Baha M. Sibai, Vesna D. Garovic, Liang Xie
Publikováno v:
Journal of Clinical Investigation. 128:5008-5017
Preeclampsia remains a clinical challenge due to its poorly understood pathogenesis. A prevailing notion is that increased placental production of soluble fms-like tyrosine kinase-1 (sFlt-1) causes the maternal syndrome by inhibiting proangiogenic pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e7765e6274eea8f8bfbf9558af5389d
https://doi.org/10.1172/jci99026
https://doi.org/10.1172/jci99026
Autor:
Christopher L. Newman, Neal X. Chen, Sharon M. Moe, Matthew R. Allen, Jason M. Organ, Michaela Kneissel, Ina Kramer, Vincent H. Gattone
Publikováno v:
Journal of Bone and Mineral Research. 30:499-509
Chronic Kidney Disease (CKD) is associated with abnormalities in bone quantity and quality leading to increased fractures. Recent studies suggest abnormalities of Wnt signaling in animal models of CKD and elevated sclerostin levels in patients with C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6fbd0084e4f4447142c5f5ef952a608
https://doi.org/10.1002/jbmr.2372
https://doi.org/10.1002/jbmr.2372
Publikováno v:
Journal of translational internal medicine. 4(3)
Background and Objectives The studies were designed to test the efficacy of two peroxisome proliferator-activated receptor γ (PPARγ) agonists in two rodent models of polycystic kidney disease (PKD). Materials and Methods The PCK rat is a slowly pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b970688ba45e05b6d86acd06bd2cba1c
https://pubmed.ncbi.nlm.nih.gov/28191533
https://pubmed.ncbi.nlm.nih.gov/28191533
Autor:
Matthew R. Allen, Christopher L. Newman, Xianming Chen, Jason M. Organ, Sharon M. Moe, Vincent H. Gattone, Neal X. Chen
Publikováno v:
Journal of Bone and Mineral Research. 29:902-910
Patients with chronic kidney disease (CKD) have increased risk of fractures, yet the optimal treatment is unknown. In secondary analyses of large randomized trials, bisphosphonates have been shown to improve bone mineral density and reduce fractures.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::357feae20b64638921e5a5471d569565
https://doi.org/10.1002/jbmr.2089
https://doi.org/10.1002/jbmr.2089