Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Vincent Giguere"'
Autor:
Madhulika Tripathi, Karine Gauthier, Reddemma Sandireddy, Jin Zhou, Priyanka Guptta, Suganya Sakthivel, Wei Wen Teo, Yadanar Than Naing, Kabilesh Arul, Keziah Tikno, Sung-Hee Park, Yajun Wu, Lijin Wang, Boon-Huat Bay, Lei Sun, Vincent Giguere, Pierce K.H. Chow, Sujoy Ghosh, Donald P. McDonnell, Paul M. Yen, Brijesh K. Singh
Publikováno v:
Molecular Metabolism, Vol 87, Iss , Pp 101997- (2024)
Objective: Currently, little is known about the mechanism(s) regulating global and specific protein translation during metabolic dysfunction-associated steatohepatitis (MASH; previously known as non-alcoholic steatohepatitis, NASH). Methods: Unbiased
Externí odkaz:
https://doaj.org/article/17f87e3dbde54cfa8579d8857c0fe2d1
Combined α- and β-adrenergic receptor activation triggers thermogenesis by the futile creatine cycle
Autor:
Lawrence Kazak, Janane Rahbani, Charlotte Scholtes, Damien Lagarde, Mohammed Faiz Hussain, Anna Roesler, Christien Dykstra, Jakub Bunk, Bozena Samborska, Shannon O’Brien, Emma Tripp, Alain Pacis, Anthony Angueira, Olivia Sveidahl Johansen, Jessica Cinkornpumin, Ishtiaque Hossain, Matthew Lynes, Yang Zhang, Andrew White, William Pastor, Maria Chondronikola, Labros Sidossis, Samuel Klein, Anastasia Kralli, Aaron Cypess, Steen Pedersen, Niels Jessen, Yu-Hua Tseng, Zachary Gerhart-Hines, Patrick Seale, Davide Calebiro, Vincent Giguere
Noradrenaline is the primary physiological regulator of adipocyte thermogenesis in response to decreased environmental temperature1. However, the molecular factors and effector pathways that lie downstream of noradrenaline-stimulated thermogenesis ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01f7b5b1a7144916d58b374283929191
https://doi.org/10.21203/rs.3.rs-1190032/v1
https://doi.org/10.21203/rs.3.rs-1190032/v1
Autor:
Charlotte Scholtes, Catherine Rosa Dufour, Emma Pleynet, Samaneh Kamyabiazar, Phillipe Hutton, Reeba Baby, Christina Guluzian, Vincent Giguère
Publikováno v:
Molecular Metabolism, Vol 83, Iss , Pp 101925- (2024)
Objectives: Estrogen-related-receptor α (ERRα) plays a critical role in the transcriptional regulation of cellular bioenergetics and metabolism, and perturbations in its activity have been associated with metabolic diseases. While several coactivat
Externí odkaz:
https://doaj.org/article/be593ace1cb9409eb9f361951b5682a4
Autor:
Hui Xia, Catherine R. Dufour, Younes Medkour, Charlotte Scholtes, Yonghong Chen, Christina Guluzian, Wafa B’chir, Vincent Giguère
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-24 (2023)
Abstract Nonalcoholic steatohepatitis (NASH) is epidemiologically associated with obesity and diabetes and can lead to liver cirrhosis and hepatocellular carcinoma if left untreated. The intricate signaling pathways that orchestrate hepatocyte energy
Externí odkaz:
https://doaj.org/article/3b6a7f6e8667402eb57710d3ab15990d
Autor:
Mehdi Amiri, Stephen J. Kiniry, Anthony P. Possemato, Niaz Mahmood, Tayebeh Basiri, Catherine R. Dufour, Negar Tabatabaei, Qiyun Deng, Michael A. Bellucci, Keerthana Harwalkar, Matthew P. Stokes, Vincent Giguère, Randal J. Kaufman, Yojiro Yamanaka, Pavel V. Baranov, Soroush Tahmasebi, Nahum Sonenberg
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113615- (2024)
Summary: The integrated stress response (ISR) is critical for cell survival under stress. In response to diverse environmental cues, eIF2α becomes phosphorylated, engendering a dramatic change in mRNA translation. The activation of ISR plays a pivot
Externí odkaz:
https://doaj.org/article/18af2fe7b35548578596dd8ed96f88ce
Publikováno v:
Molecular Metabolism, Vol 78, Iss , Pp 101814- (2023)
Objective: Estrogen related receptor α (ERRα) occupies a central node in the transcriptional control of energy metabolism, including in skeletal muscle, but whether modulation of its activity can directly contribute to extend endurance to exercise
Externí odkaz:
https://doaj.org/article/5d771d0cba1b42ba8fffd879664d284a
Autor:
Aymen A. Shatnawi, Vincent Giguere
Publikováno v:
Cancer Research. 79:5253-5253
Breast cancer is one of the most frequently diagnosed tumors in the United States that affects one in eight women during their lifetime. It is second only to lung cancer as cause of cancer death in women. The orphan members of the nuclear receptor su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59edcd62a0490a3b2adb157c85d50342
https://doi.org/10.1158/1538-7445.am2019-5253
https://doi.org/10.1158/1538-7445.am2019-5253
Autor:
Catherine R. Dufour, Hui Xia, Wafa B’chir, Marie-Claude Perry, Uros Kuzmanov, Anastasiia Gainullina, Kurt Dejgaard, Charlotte Scholtes, Carlo Ouellet, Dongmei Zuo, Virginie Sanguin-Gendreau, Christina Guluzian, Harvey W. Smith, William J. Muller, Etienne Audet-Walsh, Alexey A. Sergushichev, Andrew Emili, Vincent Giguère
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
Murine hearts deficient in ErbB2 and/or ERRα are used to profile the adverse cardiac remodeling associated with potential targeted breast cancer treatments by phosphoproteomic, transcriptomic and metabolomic profiling.
Externí odkaz:
https://doaj.org/article/ddcceb39187b47f3a0dc86d4bc298e2e
Autor:
Hui Xia, Charlotte Scholtes, Catherine R. Dufour, Carlo Ouellet, Majid Ghahremani, Vincent Giguère
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
The downstream mechanisms involved in insulin signaling and resistance remain incompletely understood. Here the authors report that insulin-dependent dephosphorylation stabilizes ERRα via the GSK3β/FBXW7 axis, and disruption of this post-translatio
Externí odkaz:
https://doaj.org/article/98a7e44b7691443e97195002ca9703a0
Autor:
Mathieu Paquette, Ming Yan, Josué M. J. Ramírez-Reyes, Leeanna El-Houjeiri, Marco Biondini, Catherine R. Dufour, Hyeonju Jeong, Alain Pacis, Vincent Giguère, Jennifer L. Estall, Peter M. Siegel, Étienne Audet-Walsh, Arnim Pause
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Non-alcoholic fatty liver disease (NAFLD) is the most frequent liver disease worldwide and can progress to non-alcoholic steatohepatitis (NASH), which is characterized by triglyceride accumulation, inflammation, and fibrosis. No pharmacologi
Externí odkaz:
https://doaj.org/article/1475e426b13d4372960b3695a52f08dd