Výsledky vyhledávání - "Vincent Gaumet"

Akademický článek

Synthesis and In Vitro Comparison of DOTA, NODAGA and 15-5 Macrocycles as Chelators for the 64Cu-Labelling of Immunoconjugates

Autor: Aurélie Maisonial-Besset, Tiffany Witkowski, Mercedes Quintana, Sophie Besse, Vincent Gaumet, Axel Cordonnier, Cyrille Alliot, Aurélien Vidal, Caroline Denevault-Sabourin, Sébastien Tarrit, Sophie Levesque, Elisabeth Miot-Noirault, Jean-Michel Chezal

Publikováno v: Molecules, Vol 28, Iss 1, p 75 (2022)

The development of 64Cu-based immuno-PET radiotracers requires the use of copper-specific bifunctional chelators (BFCs) that contain functional groups allowing both convenient bioconjugation and stable copper complexes to limit in vivo bioreduction,

Externí odkaz: https://doaj.org/article/89ab06b2726f431d8c2c4fbde3d019d8

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Akademický článek

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Design, synthesis and evaluation of targeted hypoxia-activated prodrugs applied to chondrosarcoma chemotherapy

Autor: Yvain Gerard, Sébastien Tarrit, Donia Ghedira, Elise Maubert, Elisabeth Miot-Noirault, Jean-Michel Chezal, Vincent Gaumet, Marie-Josèphe Galmier, Damien Canitrot, Aurélien Voissiere, Valérie Weber, Caroline Peyrode

Publikováno v: Bioorganic Chemistry
Bioorganic Chemistry, Elsevier, 2020, 98, pp.103747. ⟨10.1016/j.bioorg.2020.103747⟩
Bioorganic Chemistry, 2020, 98, pp.103747. ⟨10.1016/j.bioorg.2020.103747⟩

International audience; The tumor microenvironment in chondrosarcoma (CHS), a chemo- and radio-resistant cancer provides unique hallmarks for developing a chondrosarcoma targeted drug-delivery system. Tumor targeting could be achieved using a quatern

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361f02285fce4f43801dc08e9e87bfb7
https://hal.uca.fr/hal-02866765/document

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Radiomarquage du NTP 15-5 ciblant les protéoglycanes pour l’imagerie TEP des pathologies du cartilage : comparaison d’un traceur TEP à un traceur TEMP

Autor: Françoise Degoul, E. Miot Noirault, Philippe Auzeloux, Jean-Michel Chezal, Vincent Gaumet, C. Valla, Florent Cachin, E. Jouberton

Publikováno v: Médecine Nucléaire
Médecine Nucléaire, Elsevier/Masson, 2017, 41 (3), pp.160-161. ⟨10.1016/j.mednuc.2017.02.061⟩
Médecine Nucléaire-Imagerie Fonctionnelle et Métabolique
Médecine Nucléaire-Imagerie Fonctionnelle et Métabolique, 2017, 41 (3), pp.160-161. ⟨10.1016/j.mednuc.2017.02.061⟩

Introduction Le NTP 15-5, grâce a sa fonction ammonium quaternaire chargee positivement, est un ligand ciblant les proteoglycanes de la matrice extracellulaire cartilagineuse charges negativement. Differentes etudes precliniques ont demontre la pert

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::204649515f64ab1c96bd271cb3ad27bc
https://hal.archives-ouvertes.fr/hal-01677505

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Proteoglycans as Target for an Innovative Therapeutic Approach in Chondrosarcoma: Preclinical Proof of Concept

Autor: Aurélien Vidal, Michèle Borel, Elisabeth Miot-Noirault, Mercedes Quintana, Valérie Weber, Aurélie Maisonial-Besset, Vincent Gaumet, Françoise Degoul, Françoise Rédini, Aurélien Voissiere, Marie-Mélanie Dauplat, Philippe Auzeloux, Jean-Michel Chezal, Caroline Peyrode

Publikováno v: Molecular Cancer Therapeutics
Molecular Cancer Therapeutics, American Association for Cancer Research, 2016, 15 (11), pp.2575-2585. ⟨10.1158/1535-7163.MCT-16-0003⟩

To date, surgery remains the only option for the treatment of chondrosarcoma, which is radio- and chemoresistant due in part to its large extracellular matrix (ECM) and poor vascularity. In case of unresectable locally advanced or metastatic diseases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10241e86f26611dd208dffde0327a8de
https://hal.archives-ouvertes.fr/hal-01636341

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Macrocyclic complexes, their process of preparation and use as PET imaging agents

Autor: Vincent Gaumet, Claire Denis, Aurélien Vidal, Philippe Auzeloux, Jean-Claude Madelmont, Elisabeth Miot - Noirault, Jean-Michel CHEZAL

Publikováno v: France, Patent n° : WO2016016272 (A1). 2016
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The present invention concerns compounds of formula (I):their process of preparation and compositions thereof. The present invention also concerns their use as diagnostic agent in PET imaging.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::51ea4a56b0ace38a602c3ed5fb0b8344
https://hal.archives-ouvertes.fr/hal-02885526

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