Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Vincent Frappier"'
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 12, p e1010777 (2022)
The Elastic Network Contact Model (ENCoM) is a coarse-grained normal mode analysis (NMA) model unique in its all-atom sensitivity to the sequence of the studied macromolecule and thus to the effect of mutations. We adapted ENCoM to simulate the dynam
Externí odkaz:
https://doaj.org/article/cbe7ebaef9084d8bb863e2b237ab69ff
Publikováno v:
Cell Reports, Vol 18, Iss 10, Pp 2310-2319 (2017)
Sirtuin enzymes depend on NAD+ to catalyze protein deacetylation. Therefore, the lowering of NAD+ during aging leads to decreased sirtuin activity and may speed up aging processes in laboratory animals and humans. In this study, we used a genetic scr
Externí odkaz:
https://doaj.org/article/1d252bad54af4c79b5877aa6ce62fb6a
Autor:
John Ingraham, Max Baranov, Zak Costello, Vincent Frappier, Ahmed Ismail, Shan Tie, Wujie Wang, Vincent Xue, Fritz Obermeyer, Andrew Beam, Gevorg Grigoryan
Three billion years of evolution have produced a tremendous diversity of protein molecules, and yet the full potential of this molecular class is likely far greater. Accessing this potential has been challenging for computation and experiments becaus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1986967a55940d5f897f0b7b575d210b
https://doi.org/10.1101/2022.12.01.518682
https://doi.org/10.1101/2022.12.01.518682
Autor:
Danny Létourneau, Aurélien Lorin, Andrée Lefebvre, Vincent Frappier, Francis Gaudreault, Rafael Najmanovich, Pierre Lavigne, Jean-Guy LeHoux
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 12, Pp 2677-2689 (2012)
Steroidogenic acute regulatory-related lipid transfer (START) domain proteins are involved in the nonvesicular intracellular transport of lipids and sterols. The STARD1 (STARD1 and STARD3) and STARD4 subfamilies (STARD4–6) have an internal cavity l
Externí odkaz:
https://doaj.org/article/3e20e8ba00a143d4839f5733c94465a5
Autor:
Vincent Frappier, Amy E. Keating
Publikováno v:
Prof. Amy Keating
Curr Opin Struct Biol
Curr Opin Struct Biol
Computational protein design can generate proteins not found in nature that adopt desired structures and perform novel functions. Although proteins could, in theory, be designed with ab initio methods, practical success has come from using large amou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63f238291ea3ce4a5b3b931c49969e2
https://hdl.handle.net/1721.1/131227
https://hdl.handle.net/1721.1/131227
Autor:
Vincent Frappier, Rafael J Najmanovich
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 4, p e1003569 (2014)
Normal mode analysis (NMA) methods are widely used to study dynamic aspects of protein structures. Two critical components of NMA methods are coarse-graining in the level of simplification used to represent protein structures and the choice of potent
Externí odkaz:
https://doaj.org/article/033ae2d5bb2241dbb2053e8725f9c440
Autor:
Leonardo Astolfi Rosado, Igor Bordin Vasconcelos, Mário Sérgio Palma, Vincent Frappier, Rafael Josef Najmanovich, Diógenes Santiago Santos, Luiz Augusto Basso
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e61918 (2013)
Tuberculosis remains as one of the main cause of mortality worldwide due to a single infectious agent, Mycobacterium tuberculosis. The aroK-encoded M. tuberculosis Shikimate Kinase (MtSK), shown to be essential for survival of bacilli, catalyzes the
Externí odkaz:
https://doaj.org/article/4b60fdc1e6ee43cf83713bfcc13c10b7
Publikováno v:
Protein Science. 27:276-285
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67a4f5069c47a3d7c7b471c9f1e68aa2
https://doi.org/10.1002/pro.3320
https://doi.org/10.1002/pro.3320
Publikováno v:
Cell Reports, Vol 18, Iss 10, Pp 2310-2319 (2017)
Elsevier
Elsevier
Sirtuin enzymes depend on NAD⁺ to catalyze protein deacetylation. Therefore, the lowering of NAD⁺ during aging leads to decreased sirtuin activity and may speed up aging processes in laboratory animals and humans. In this study, we used a genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93a8a7f0b89530a57b4ec2b7e3f08eb8
https://doi.org/10.1016/j.celrep.2017.02.031
https://doi.org/10.1016/j.celrep.2017.02.031
Publikováno v:
Protein Science. 27:1535-1537
PixelDB, the Peptide Exosite Location Database, compiles 1966 non‐redundant, high‐resolution structures of protein–peptide complexes filtered to minimize the impact of crystal packing on peptide conformation. The database is organized to facili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::251234f7d3c42bba22c5bab5a956e433
https://doi.org/10.1002/pro.3431
https://doi.org/10.1002/pro.3431