Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Vincent F.S. Dubois"'
Autor:
Oscar Della Pasqua, Meindert Danhof, Huixin Yu, Ramona Graf, Vincent F.S. Dubois, Giovanni Smania, Anne S. Y. Chain
Publikováno v:
British Journal of Clinical Pharmacology. 83:349-362
Aim In spite of screening procedures in early drug development, uncertainty remains about the propensity of new chemical entities (NCEs) to prolong the QT/QTc interval. The evaluation of proarrhythmic activity using a comprehensive in vitro proarrhyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::720fb48a8ac46516a23cb2720ee5f23c
https://doi.org/10.1111/bcp.13123
https://doi.org/10.1111/bcp.13123
Publikováno v:
British Journal of Clinical Pharmacology. 79:148-161
Aims Significant differences between dogs and humans have been observed in the concentration–QTc effect relationship of compounds with known pro-arrhythmic properties. These findings suggest that interspecies differences must be considered when eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08cea71458ceadc423b9ccfc04f9d2e9
https://doi.org/10.1111/bcp.12482
https://doi.org/10.1111/bcp.12482
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 81:355
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74c7a6c304ad41f774526fe3bf23792f
https://doi.org/10.1016/j.vascn.2016.02.066
https://doi.org/10.1016/j.vascn.2016.02.066
Autor:
Vincent F.S. Dubois, Anne Chain, Piet van der Graaf, Mark Holbrook, Derek Leishman, David Gallacher, Meindert Danhof, Oscar Della Pasqua
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 64:e35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d4195533e2d66e10c5bd8be4e244e30
https://doi.org/10.1016/j.vascn.2011.03.123
https://doi.org/10.1016/j.vascn.2011.03.123
Autor:
TI Pharma Pkpd Platform, W. E. A. de Witte, Vincent F.S. Dubois, O Della Pasqua, Meindert Danhof, Sandra A.G. Visser
Publikováno v:
PHARMACEUTICAL RESEARCH
Pharmaceutical Research
Pharmaceutical Research
BACKGROUND AND PURPOSE The selection of the most suitable animal species and subsequent translation of the concentration-effect relationship to humans are critical steps for accurate assessment of the pro-arrhythmic risk of candidate molecules. The o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcf25a3265be9e9684b697c027b416b9