Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Vincent E. Manetta"'
Autor:
Alfred P. Spada, Robert J. Leadley, Jonathan S. Mason, Dennis J. Colussi, Ewing William R, Mark H. Perrone, Karen D. Brown, Michael R. Becker, Don D. Cha, Daniel M. Green, Ross Bentley, Henry W. Pauls, Christopher T. Dunwiddie, Jean-Pierre Guilloteau, Y.M. Choi-Sledeski, Sebastien Maignan, Mason Helen J, Vincent E. Manetta, Charles Kasiewski, Valeria Chu, Roderick S. Davis, Suzanne Morgan, Daniel L. Cheney, Jeff Bostwick
Publikováno v:
Journal of Medicinal Chemistry. 42:3557-3571
The discovery of a series of non-peptide factor Xa (FXa) inhibitors incorporating 3-(S)-amino-2-pyrrolidinone as a central template is described. After identifying compound 4, improvements in in vitro potency involved modifications of the liphophilic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2009f497bb352b54bc0c7e881834e15b
https://doi.org/10.1021/jm990040h
https://doi.org/10.1021/jm990040h
Publikováno v:
Carbohydrate Research. 278:345-350
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7e41b95f0f85e851dfb9a98d9e67a5a
https://doi.org/10.1016/0008-6215(95)00256-1
https://doi.org/10.1016/0008-6215(95)00256-1
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0e7c2c4a6ccab2923687733ceea08ab
https://doi.org/10.1002/chin.199615231
https://doi.org/10.1002/chin.199615231
Autor:
Sébastien Maignan, Davis Roderick S, Dunwiddie Christopher T, Michael R. Becker, William P. Dankulich, Karen Brown, Jean-Pierre Guilloteau, Mcgarry Daniel G, Daniel M. Green, Christopher L. Heran, Robert L. Morris, Robert J. Leadley, Spada Alfred P, Ross G. Bentley, William R. Ewing, Helen J. Mason, Valeria Chu, Y.M. Choi-Sledeski, Suzanne R Morgan, Daniel L. Cheney, Pauls Henry W, Dennis Colussi, Vincent E. Manetta
Publikováno v:
Journal of medicinal chemistry. 42(18)
Sulfonamidopyrrolidinones were previously disclosed as a selective class of factor Xa (fXa) inhibitors, culminating in the identification of RPR120844 as a potent member with efficacy in vivo. Recognizing the usefulness of the central pyrrolidinone t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816ed36d69dbaf13b89813b523b7aa90
https://pubmed.ncbi.nlm.nih.gov/10479289
https://pubmed.ncbi.nlm.nih.gov/10479289
Autor:
Scott A. Bolton, Charles Pendley, Bruce F. Molino, Alison Capilino, W. Richard Ewing, Vincent E. Manetta
Publikováno v:
Peptides 1992 ISBN: 9789401046466
Peptides 1992
Peptides 1992
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2274316892d936f0eee23356a01dcf9f
https://doi.org/10.1007/978-94-011-1470-7_280
https://doi.org/10.1007/978-94-011-1470-7_280
