Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Vincent D. Giacalone"'
Autor:
Vincent D. Giacalone, Diego Moncada Giraldo, George L. Silva, Justin Hosten, Limin Peng, Lokesh Guglani, Rabindra Tirouvanziam
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundIn chronic cystic fibrosis (CF) lung disease, neutrophilic inflammation and T-cell inhibition occur concomitantly, partly due to neutrophil-mediated release of the T-cell inhibitory enzyme Arg1. However, the onset of this tonic inhibition o
Externí odkaz:
https://doaj.org/article/7e6f7718de3741c8bcfe8d9d1b87c4d6
Autor:
Lisa J. M. Slimmen, Vincent D. Giacalone, Craig Schofield, Hamed Horati, Badies H. A. N. Manaï, Silvia C. Estevão, Luke W. Garratt, Limin Peng, Rabindra Tirouvanziam, Hettie M. Janssens, Wendy W. J. Unger
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundCystic fibrosis (CF) airway disease is characterized by chronic inflammation, featuring neutrophil influx to the lumen. Airway macrophages (AMs) can promote both inflammation and resolution, and are thus critical to maintaining and restorin
Externí odkaz:
https://doaj.org/article/eae098652c744ae8b87cdc096ccd1b5e
Autor:
Brian Dobosh, Keivan Zandi, Diego Moncada Giraldo, Shu Ling Goh, Kathryn Musall, Milagros Aldeco, Julia LeCher, Vincent D. Giacalone, Junkai Yang, Devon J. Eddins, Manoj Bhasin, Eliver Ghosn, Vikas Sukhatme, Raymond F. Schinazi, Rabindra Tirouvanziam
Publikováno v:
Cell Reports, Vol 39, Iss 11, Pp 110945- (2022)
Summary: SARS-CoV-2-infected subjects are generally asymptomatic during initial viral replication but may suffer severe immunopathology after the virus has receded and monocytes have infiltrated the airways. In bronchoalveolar lavage fluid from sever
Externí odkaz:
https://doaj.org/article/ea7bd0ec72344e9d92d16f88c63dabad
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100892- (2021)
Summary: Neutrophils are difficult to study, particularly in tissues, due to their short half-life and propensity for activation. We describe an organotypic airway model that uses patient airway fluid to enable the transmigration of blood neutrophils
Externí odkaz:
https://doaj.org/article/a18880fe04d04f668d20c3de25909a88
Autor:
Kirsten A. Cottrill, Vincent D. Giacalone, Camilla Margaroli, Robert J. Bridges, Michael Koval, Rabindra Tirouvanziam, Nael A. McCarty
Publikováno v:
Physiological Reports, Vol 9, Iss 17, Pp n/a-n/a (2021)
Abstract Loss of function of the cystic fibrosis transmembrane conductance regulator (CFTR) causes cystic fibrosis (CF). In the lungs, this manifests as immune cell infiltration and bacterial infections, leading to tissue destruction. Previous work h
Externí odkaz:
https://doaj.org/article/643f626715024b628d46003c13d0b820
Autor:
Camilla Margaroli, Diego Moncada-Giraldo, Dalia Arafat Gulick, Brian Dobosh, Vincent D. Giacalone, Osric A. Forrest, Fangxu Sun, Chunhui Gu, Amit Gaggar, Haydn Kissick, Ronghu Wu, Greg Gibson, Rabindra Tirouvanziam
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 4, Pp 100239- (2021)
Summary: Neutrophils are often considered terminally differentiated and poised for bacterial killing. In chronic diseases such as cystic fibrosis (CF), an unexplained paradox pits massive neutrophil presence against prolonged bacterial infections. He
Externí odkaz:
https://doaj.org/article/330b3a1590594f2eba3bc5803c699101
Autor:
Bijean D. Ford, Diego Moncada Giraldo, Camilla Margaroli, Vincent D. Giacalone, Milton R. Brown, Limin Peng, Rabindra Tirouvanziam
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5, p 2530 (2021)
Cystic fibrosis (CF) lung disease is dominated by the recruitment of myeloid cells (neutrophils and monocytes) from the blood which fail to clear the lung of colonizing microbes. In prior in vitro studies, we showed that blood neutrophils migrated th
Externí odkaz:
https://doaj.org/article/f7bf81963bba4a63bd364f0026435751
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 9, p 3331 (2020)
Cystic fibrosis (CF) lung disease is characterized by unconventional mechanisms of inflammation, implicating a chronic immune response dominated by innate immune cells. Historically, therapeutic development has focused on the mutated cystic fibrosis
Externí odkaz:
https://doaj.org/article/792fd01b59664e3abb2f4ff7b85e2b3d
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 3, p 851 (2020)
Neutrophils have a prominent role in all human immune responses against any type of pathogen or stimulus. The lungs are a major neutrophil reservoir and neutrophilic inflammation is a primary response to both infectious and non-infectious challenges.
Externí odkaz:
https://doaj.org/article/888e4d20648748de9a65bcacf59cf8ff
Autor:
Devon J. Eddins, Junkai Yang, Astrid Kosters, Vincent D. Giacalone, Ximo Pechuan-Jorge, Joshua D. Chandler, Jinyoung Eum, Benjamin R. Babcock, Brian S. Dobosh, Mindy R. Hernández, Fathma Abdulkhader, Genoah L. Collins, Darya Y. Orlova, Richard P. Ramonell, Ignacio Sanz, Christine Moussion, F. Eun-Hyung Lee, Rabindra M. Tirouvanziam, Eliver E. B. Ghosn
Publikováno v:
Blood Advances. 7:778-799
Troubling disparities in COVID-19–associated mortality emerged early, with nearly 70% of deaths confined to Black/African American (AA) patients in some areas. However, targeted studies on this vulnerable population are scarce. Here, we applied mul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac9e7ec8b0578ecc8dd4d1f7d691b1a2
https://doi.org/10.1182/bloodadvances.2022008834
https://doi.org/10.1182/bloodadvances.2022008834