Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Vincent C.J. de Boer"'
Autor:
Taolin Yuan, Surinder Kumar, Mary E. Skinner, Ryan Victor-Joseph, Majd Abuaita, Jaap Keijer, Jessica Zhang, Thaddeus J. Kunkel, Yanghan Liu, Elyse M. Petrunak, Thomas L. Saunders, Andrew P. Lieberman, Jeanne A. Stuckey, Nouri Neamati, Fathiya Al-Murshedi, Majid Alfadhel, Johannes N. Spelbrink, Richard Rodenburg, Vincent C.J. de Boer, David B. Lombard
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109991- (2024)
Summary: SIRT5 is a sirtuin deacylase that removes negatively charged lysine modifications, in the mitochondrial matrix and elsewhere in the cell. In benign cells and mouse models, under basal conditions, the phenotypes of SIRT5 deficiency are quite
Externí odkaz:
https://doaj.org/article/1b3e08c25bb044469b8c3e5f02f889fd
Autor:
Onno Kranenburg, Inne H.M. Borel Rinkes, Jan Koster, Benjamin L. Emmink, Nikol Snoeren, Andre Verheem, Kari Trumpi, Susanne van Schelven, Szabolcs Fatrai, Vincent C.J. de Boer, Tijana Borovski, Thomas T. Vellinga
Supplementary tables S1-6. Supplementary table S1 Primers used for RT-qPCR analyses. Supplementary table S2 Clinical variables associated with differences in gene expression among 119 resected liver metastases. Supplementary table S3 613 genes whose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8273ba885637fe642092f2815b95eb39
https://doi.org/10.1158/1078-0432.22460445.v1
https://doi.org/10.1158/1078-0432.22460445.v1
Autor:
Onno Kranenburg, Inne H.M. Borel Rinkes, Jan Koster, Benjamin L. Emmink, Nikol Snoeren, Andre Verheem, Kari Trumpi, Susanne van Schelven, Szabolcs Fatrai, Vincent C.J. de Boer, Tijana Borovski, Thomas T. Vellinga
Purpose: Chemotherapy treatment of metastatic colon cancer ultimately fails due to development of drug resistance. Identification of chemotherapy-induced changes in tumor biology may provide insight into drug resistance mechanisms.Experimental Design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::279b1c3fb644fc6dbc77d1ed65c39b1e
https://doi.org/10.1158/1078-0432.c.6524493
https://doi.org/10.1158/1078-0432.c.6524493
Autor:
Onno Kranenburg, Inne H.M. Borel Rinkes, Jan Koster, Benjamin L. Emmink, Nikol Snoeren, Andre Verheem, Kari Trumpi, Susanne van Schelven, Szabolcs Fatrai, Vincent C.J. de Boer, Tijana Borovski, Thomas T. Vellinga
Supplementary Figures S1-3. Supplementary figure S1 Cytochrome c oxidase (COX IV) is highly expressed in chemotherapy-treated liver metastases Supplementary figure S2 Expression changes of glycolytic and OXPHOS genes in response to chemotherapy. Supp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6976d07ab45114ce81e9399aed0ad4e1
https://doi.org/10.1158/1078-0432.22460448.v1
https://doi.org/10.1158/1078-0432.22460448.v1
Autor:
Rogier Versteeg, Jihye Paik, Evan E. Santo, Ninna S. Hansen, Peter Stroeken, Vincent C.J. de Boer, Ellen M. Westerhout, Rasmus Ribel-Madsen, Allan Vaag, Maaike Commandeur
Publikováno v:
Aging Cell, 22(3)
Aging Cell 22 (2023) 3
Aging Cell 22 (2023) 3
In humans, intronic polymorphisms in FOXO3A are associated with extreme longevity. Despite many studies reporting this association it is unclear how these polymorphisms alter FOXO3A functionality and human physiology thereby influencing human lifespa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c309be82e97651572214104cb963990
https://research.wur.nl/en/publications/foxo3a-short-is-a-novel-regulator-of-non-oxidative-glucose-metabo
https://research.wur.nl/en/publications/foxo3a-short-is-a-novel-regulator-of-non-oxidative-glucose-metabo
Autor:
Joëlle J.E. Janssen, Bart Lagerwaard, Arie G. Nieuwenhuizen, Xavier Escoté, Núria Canela, Josep M. del Bas, Vincent C.J. de Boer, Jaap Keijer
Background Biomarkers are important in the assessment of health and disease but are poorly studied in healthy individuals. Especially responses of biomarkers in the systemic circulation to longer-term and short-term lifestyle interventions are incomp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cb8b5295dff383c52b16bd3f8173ab6
https://doi.org/10.21203/rs.3.rs-1745399/v1
https://doi.org/10.21203/rs.3.rs-1745399/v1
Autor:
Anthony A. Sauve, Lydia W.S. Finley, Thaddeus T. Schug, Vincent C.J. de Boer, Yana Cen, Seung Min Jeong, Xiaoling Li, Hong Lu, Meredith Sweeney, Gaëlle Laurent, Marcia C. Haigis
Publikováno v:
Molecular and Cellular Biology 33 (2013) 22
Molecular and Cellular Biology, 33(22), 4552-4561
Molecular and cellular biology, 33(22), 4552-4561. American Society for Microbiology
Molecular and Cellular Biology, 33(22), 4552-4561
Molecular and cellular biology, 33(22), 4552-4561. American Society for Microbiology
Sirtuins are a family of protein deacetylases, deacylases, and ADP-ribosyltransferases that regulate life span, control the onset of numerous age-associated diseases, and mediate metabolic homeostasis. We have uncovered a novel role for the mitochond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b6c09d512f8481bb44dde2d3f2c8f20
Autor:
Arlene H. Sharpe, Gina Boanca, Asish K. Saha, Scott B. Lovitch, Frank Fischer, Noah Dephoure, Gaëlle Laurent, Irwin J. Kurland, Marcia C. Haigis, Michael N. Davies, Vincent C.J. de Boer, Timothy R. Koves, Clemens Steegborn, Deborah M. Muoio, Natalie J. German, Neil B. Ruderman, Bhavapriya Vaitheesvaran, Steven P. Gygi
Publikováno v:
Molecular Cell, 50(5), 686-698
Molecular cell, 50(5), 686-698. Cell Press
Molecular Cell 50 (2013) 5
Molecular cell, 50(5), 686-698. Cell Press
Molecular Cell 50 (2013) 5
Lipid metabolism is tightly controlled by the nutritional state of the organism. Nutrient-rich conditions increase lipogenesis whereas nutrient deprivation promotes fat oxidation. In this study, we identify the mitochondrial sirtuin, SIRT4, as a nove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::266e42e551706f9a99186ec9cbfdf405
https://research.wur.nl/en/publications/sirt4-coordinates-the-balance-between-lipid-synthesis-and-catabol
https://research.wur.nl/en/publications/sirt4-coordinates-the-balance-between-lipid-synthesis-and-catabol
Autor:
Andrew C. Adams, Elefteria Maratos-Flier, Pere Puigserver, Su Jung Song, Zachary T. Schafer, Ainara Egia, Manoj Bhasin, Towia A. Libermann, Gaëlle Laurent, Amy K. Leliaert, Dror Weiss, Maria Sundvall, Lydia S. Finley, Andrea L. Richardson, Keisuke Ito, Pier Paolo Pandolfi, Marcia C. Haigis, Vincent C.J. de Boer, Zachary Gerhart-Hines, Arkaitz Carracedo
Publikováno v:
Journal of Clinical Investigation, 122(9), 3088-3100
Journal of clinical investigation, 122(9), 3088-3100. The American Society for Clinical Investigation
Journal of Clinical Investigation 122 (2012) 9
Journal of clinical investigation, 122(9), 3088-3100. The American Society for Clinical Investigation
Journal of Clinical Investigation 122 (2012) 9
Cancer cells exhibit an aberrant metabolism that facilitates more efficient production of biomass and hence tumor growth and progression. However, the genetic cues modulating this metabolic switch remain largely undetermined. We identified a metaboli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ce3dfc33832880ef86fe26a2acd712d
https://research.wur.nl/en/publications/a-metabolic-prosurvival-role-for-pml-in-breast-cancer
https://research.wur.nl/en/publications/a-metabolic-prosurvival-role-for-pml-in-breast-cancer
Autor:
Vincent C.J. de Boer, Carlotta Giorgi, Lewis C. Cantley, Lucia E. Rameh, Pier Paolo Pandolfi, Paolo Pinton, Matthew G. Vander Heiden, Marcia C. Haigis, Atsuo T. Sasaki, Min Sup Song, Keisuke Ito, Gaëlle Laurent, Robin M. Hobbs, Dimitrios Anastasiou, Isabel Garcia-Cao, Arkaitz Carracedo
Publikováno v:
Cell 149 (2012) 1
Cell, 149(1), 49-62
Cell, 149(1), 49-62. Cell Press
Cell, 149(1), 49-62
Cell, 149(1), 49-62. Cell Press
Decremental loss of PTEN results in cancer susceptibility and tumor progression. In turn this raises the possibility that PTEN elevation might be an attractive option for cancer prevention and therapy. We have generated several transgenic mouse lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::544aecb09fd8627f78de02fcb4c597aa
http://hdl.handle.net/11392/1633267
http://hdl.handle.net/11392/1633267