Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Vincent C. Knick"'
Publikováno v:
JNCI Journal of the National Cancer Institute. 87:1072-1077
Background : Many critical cellular functions such as mitosis, cell movement, and maintenance of cell structure are performed by microtubules. Antimicrotubule agents (which disrupt or block the formation of microtubules) are among the most widely use
Autor:
Vincent C. Knick, David J. Adams
Publikováno v:
Investigational New Drugs. 13:13-21
Navelbine® (NVB, vinorelbine tartrate) is a semisyntheticVinca alkaloid in which the catharanthine moiety contains an eight-membered ring in place of the nine-membered ring that is present in all naturally occurring members of the vinblastine group.
Autor:
Marilyn Jansen, Gary K. Smith, David S. Duch, Jacqueline I. Lee, Michael J. Dykstra, Jeremy Stables, Peter Topley, Robert J. Mullin, Vincent C. Knick
Publikováno v:
Biochemical Pharmacology. 47:1067-1078
Clinical responses for anticancer agents are based upon tumor regression. We have investigated the potential of glycineamide ribonucleotide transformylase (GAR TFase) inhibitors to produce regressions in multiple preclinical models of colon carcinoma
Publikováno v:
ChemInform. 22
In the series of 1-pyrenylmethylamines studied in this work the relationships among structure, interaction with DNA, and murine antitumor activity were examined. Binding studies show that all of these 1-pyrenylmethylamine derivatives bind to some ext
Autor:
Derek J. Eberwein, Christian H. Ryan, Sam M. Witherspoon, Julie B. Stimmel, Linda M. Thurmond, Adrienne C. Ingram, Doris M. Murray, Vincent C. Knick
Publikováno v:
Cancer immunology, immunotherapy : CII. 52(7)
Ep-CAM antigen expression was shown to vary by phase across the cell cycle. Following pretreatment of various adenocarcinoma cells in culture with clinically relevant concentrations of vinorelbine tartrate (Navelbine) or paclitaxel (Taxol), cell surf
Autor:
Linda M. Thurmond, Jeff T. Hutchins, Vincent C. Knick, Frederick C. Kull, Jane Bynum, Paul H. Ray
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 92(26)
Radiolabeled antibodies have shown promise for the treatment of lymphoma and for solid tumor targeting. Campath-1H is a humanized monoclonal antibody that reacts with the CD52 antigen present on human lymphoid and myeloid cells. Campath-1H is a gamma
5-Ethynyluracil (5-EU, 776C85) is a mechanism-based irreversible inhibitor of dihydropyrimidine dehydrogenase (EC 1.3.1.2), the rate-determining enzyme in 5-fluorouracil (5-FU) catabolism. In the present study, 5-EU was found to be a potent modulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8ec6477a2d688474c4aeaaab7ae8e5a
https://europepmc.org/articles/PMC47922/
https://europepmc.org/articles/PMC47922/
Autor:
Richard L. Tuttle, David D. McKee, Andrews Cw, Kenneth W. Bair, Vincent C. Knick, Michael Cory
Publikováno v:
Journal of medicinal chemistry. 34(7)
The effects of variation of aromatic ring size, shape, and side-chain position on antitumor activity and DNA binding in a series of carbocyclic 2-[(arylmethyl)amino]-2-methyl-1,3-propanediols (AMAPs) were examined. In general, the interaction of AMAP
Publikováno v:
Journal of medicinal chemistry. 33(9)
In the series of 1-pyrenylmethylamines studied in this work the relationships among structure, interaction with DNA, and murine antitumor activity were examined. Binding studies show that all of these 1-pyrenylmethylamine derivatives bind to some ext