Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Vincent Abramowski"'
Autor:
Panagiotis Antoniou, Giulia Hardouin, Pierre Martinucci, Giacomo Frati, Tristan Felix, Anne Chalumeau, Letizia Fontana, Jeanne Martin, Cecile Masson, Megane Brusson, Giulia Maule, Marion Rosello, Carine Giovannangeli, Vincent Abramowski, Jean-Pierre de Villartay, Jean-Paul Concordet, Filippo Del Bene, Wassim El Nemer, Mario Amendola, Marina Cavazzana, Anna Cereseto, Oriana Romano, Annarita Miccio
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Antoniou and colleagues used base editing to generate a variety of mutations inducing γ-globin and rescue the β-hemoglobinopathy phenotype. This strategy was safe and effective in long-term repopulating hematopoietic stem/progenitor cells.
Externí odkaz:
https://doaj.org/article/313aa0fc4a794f6798f4ea808d498494
Autor:
Benoit Roch, Vincent Abramowski, Olivier Etienne, Stefania Musilli, Pierre David, Jean-Baptiste Charbonnier, Isabelle Callebaut, François D Boussin, Jean-Pierre de Villartay
Publikováno v:
eLife, Vol 10 (2021)
We developed an Xrcc4M61R separation of function mouse line to overcome the embryonic lethality of Xrcc4-deficient mice. XRCC4M61R protein does not interact with Xlf, thus obliterating XRCC4-Xlf filament formation while preserving the ability to stab
Externí odkaz:
https://doaj.org/article/9f2b7f8042e7416dbee800b5e8f5606b
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Xlf/Cernunnos is unique among the core factors of the non-homologous end joining (NHEJ) DNA double strand breaks (DSBs) repair pathway, in the sense that it is not essential for V(D)J recombination in vivo and in vitro. Unlike other NHEJ deficient mi
Externí odkaz:
https://doaj.org/article/69933967aaa446038fc4b5f7cd6f86d5
Autor:
Chloé Lescale, Vincent Abramowski, Marie Bedora-Faure, Valentine Murigneux, Gabriella Vera, David B. Roth, Patrick Revy, Jean-Pierre de Villartay, Ludovic Deriano
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Antigen receptor diversity relies on careful DNA cleavage and repair. Here the authors identify a functional interplay between RAG2 and XLF during V(D)J recombination, revealing an important role for the RAG complex in repairing induced DNA double-st
Externí odkaz:
https://doaj.org/article/45b3d85d8e094ec8ba4c1f14631de376
Autor:
Jean-Pierre de Villartay, Isabelle Callebaut, François D. Boussin, Olivier Etienne, Vincent Abramowski, Jean-Baptiste Charbonnier, Benoit Roch, Pierre David, Stefania Musilli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09a938e0c95b106626594d783a1163b3
https://doi.org/10.7554/elife.69353.sa2
https://doi.org/10.7554/elife.69353.sa2
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2020, pp.jbc.AC119.010924. ⟨10.1074/jbc.AC119.010924⟩
J Biol Chem
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2020, pp.jbc.AC119.010924. ⟨10.1074/jbc.AC119.010924⟩
J Biol Chem
Repair of DNA double-strand breaks by the nonhomologous end joining pathway is central for proper development of the adaptive immune system. This repair pathway involves eight factors, including XRCC4-like factor (XLF)/Cernunnos and the paralog of XR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e47a80cdb25a69d916803c4aec20053
https://www.hal.inserm.fr/inserm-02481526/file/2020_PAXX-XLF_JBCproof.pdf
https://www.hal.inserm.fr/inserm-02481526/file/2020_PAXX-XLF_JBCproof.pdf
Publikováno v:
Frontiers in Immunology
Xlf/Cernunnos is unique among the core factors of the non-homologous end joining (NHEJ) DNA double strand breaks (DSBs) repair pathway, in the sense that it is not essential for V(D)J recombination in vivo and in vitro. Unlike other NHEJ deficient mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1da98be07e12d757437dae47028a852b
https://pubmed.ncbi.nlm.nih.gov/30923523
https://pubmed.ncbi.nlm.nih.gov/30923523
Autor:
Ana Cumano, Benoit Roch, Laetitia Kermasson, Ramy Elsaid, Vincent Abramowski, Jean-Paul Moussu, Olivier Etienne, Aurélie Berland, Jean-Pierre de Villartay, Stefania Musilli, Patrick Revy, Junjie Yang, François D. Boussin, Karelia Lipson-Ruffert
Publikováno v:
Cell Death and Differentiation
Cell Death and Differentiation, 2018, 25 (2), pp.444-452. ⟨10.1038/cdd.2017.184⟩
Cell Death and Differentiation, Nature Publishing Group, 2018, 25 (2), pp.444-452. ⟨10.1038/cdd.2017.184⟩
Cell Death and Differentiation, 2018, 25 (2), pp.444-452. ⟨10.1038/cdd.2017.184⟩
Cell Death and Differentiation, Nature Publishing Group, 2018, 25 (2), pp.444-452. ⟨10.1038/cdd.2017.184⟩
International audience; The repair of DNA double-stranded breaks (DNAdsb) through non-homologous end joining (NHEJ) is a prerequisite for the proper development of the central nervous system and the adaptive immune system. Yet, mice with Xlf or PAXX
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e3cc9d04ecd1382b0369f5c36141e99
https://europepmc.org/articles/PMC5762856/
https://europepmc.org/articles/PMC5762856/
Cernunnos Deficiency Reduces Thymocyte Life Span and Alters the T Cell Repertoire in Mice and Humans
Autor:
Vincent Abramowski, Annick Lim, Jean-Pierre de Villartay, Sylvain Latour, Christine Bole-Feysot, Laurent Malivert, Patrick Revy, Benoit Florkin, Paola Rivera-Munoz, Christelle Martin, Gabriella Vera
Publikováno v:
Molecular and Cellular Biology. 33:701-711
Cernunnos is a DNA repair factor of the nonhomologous end-joining machinery. Its deficiency in humans causes radiosensitive severe combined immune deficiency (SCID) with microcephaly, characterized in part by a profound lymphopenia. In contrast to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbc3fbea724e220a435c4c0e3af2f826
https://doi.org/10.1128/mcb.01057-12
https://doi.org/10.1128/mcb.01057-12
Autor:
David Roth, Vincent Abramowski, Valentine Murigneux, Marie Bedora-Faure, Ludovic Deriano, Chloé Lescale, Patrick Revy, Jean-Pierre de Villartay, Gabriella Vera
Publikováno v:
Nature Communications
Nature Communications, 2016, 7, pp.Article number:10529. ⟨10.1038/ncomms10529⟩
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications, Nature Publishing Group, 2016, 7, pp.Article number:10529. ⟨10.1038/ncomms10529⟩
Nature Communications, 2016, 7, pp.Article number:10529. ⟨10.1038/ncomms10529⟩
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications, Nature Publishing Group, 2016, 7, pp.Article number:10529. ⟨10.1038/ncomms10529⟩
XRCC4-like factor (XLF) functions in classical non-homologous end-joining (cNHEJ) but is dispensable for the repair of DNA double-strand breaks (DSBs) generated during V(D)J recombination. A long-standing hypothesis proposes that, in addition to its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d74d432bb5d34792e017dec1179d1cc4
http://europepmc.org/articles/PMC4740868
http://europepmc.org/articles/PMC4740868