Anti-Cancer and Radio-Sensitizing Properties of New Bimetallic (N-Heterocyclic Carbene)-Amine-Pt(II) Complexes

Autor: Tao Jia, Oumar Diane, Deepanjan Ghosh, Myriem Skander, Gaelle Fontaine, Pascal Retailleau, Joël Poupon, Jérôme Bignon, Ytabelle Maga Moulai Siasia, Vincent Servajean, Nathalie Hue, Jean-François Betzer, Angela Marinetti, Sophie Bombard

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 2023, 66 (10), pp.6836-6848. ⟨10.1021/acs.jmedchem.3c00267⟩

International audience; Bioactive NHC-transition metal complexes have shown promise as anti-cancer agents, but their potential use as radiosensitizers has been neglected so far. We disclose here a new series of bimetallic platinum(II) complexes displ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e5350758825484445abd2a2d5b6b0ba
https://doi.org/10.1021/acs.jmedchem.3c00267

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Autor: Alexandre, de Saint Germain, Anse, Jacobs, Guillaume, Brun, Jean-Bernard, Pouvreau, Lukas, Braem, David, Cornu, Guillaume, Clavé, Emmanuelle, Baudu, Vincent, Steinmetz, Vincent, Servajean, Susann, Wicke, Kris, Gevaert, Philippe, Simier, Sofie, Goormachtig, Philippe, Delavault, François-Didier, Boyer

Publikováno v: Plant Communications

Phelipanche ramosa is an obligate root-parasitic weed that threatens major crops in central Europe. In order to germinate, it must perceive various structurally divergent host-exuded signals, including isothiocyanates (ITCs) and strigolactones (SLs).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fffcfd4b6a5d3c7b5dd1d750cf7b18cf
https://pubmed.ncbi.nlm.nih.gov/34746757

Total Synthesis of Tiacumicin B: Implementing Hydrogen Bond Directed Acceptor Delivery for Highly Selective β‐Glycosylations

Autor: Cédric Tresse, Guillaume Masson, Grégory Genta-Jouve, Jean-Marie Beau, Emmanuel Roulland, Louis Jeanne-Julien, Vincent Servajean, Stéphanie Norsikian, Marc François-Eude

Publikováno v: Angewandte Chemie International Edition
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2020, 59 (16), pp.6612-6616. ⟨10.1002/anie.202000231⟩
Angewandte Chemie
Angewandte Chemie, Wiley-VCH Verlag, 2020, 132 (16), pp.6674-6678. ⟨10.1002/ange.202000231⟩
Angewandte Chemie International Edition, 2020, 59 (16), pp.6612-6616. ⟨10.1002/anie.202000231⟩

International audience; We report a total synthesis of tiacumicin B, a natural macrolide whose remarkable antibiotic properties are used to treat severe intestinal infections. The strategy is in part based on our experience of the synthesis of the ti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c19af86d0ae67b1c097a7bc0a26f5ba
https://hal.archives-ouvertes.fr/hal-02560216

Synthesis of a Tiacumicin B Protected Aglycone

Autor: Grégory Genta-Jouve, Jean-Marie Beau, Louis Jeanne-Julien, Guillaume S. Masson, Stéphanie Norsikian, Eloi Astier, Vincent Servajean, Emmanuel Roulland

Publikováno v: Organic Letters. 19:4006-4009

Tiacumicin B is an antibiotic endowed with the remarkable ability to interact with a new biological target, giving it an inestimable potential in the context of the ever-growing and worrisome appearance of resistances of bacteria and mycobacteria to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff93792b82de235ded29e8bcd4c08851
https://doi.org/10.1021/acs.orglett.7b01744

Study of the Construction of the Tiacumicin B Aglycone

Autor: Stéphanie Norsikian, Grégory Genta-Jouve, Jean-Marie Beau, Louis Jeanne-Julien, Emmanuel Roulland, Vincent Servajean, Eloi Astier, Guillaume Masson

Publikováno v: Journal of Organic Chemistry
Journal of Organic Chemistry, 2018, 83 (2), pp.921-929. ⟨10.1021/acs.joc.7b02909⟩
Journal of Organic Chemistry, American Chemical Society, 2018, 83 (2), pp.921-929. ⟨10.1021/acs.joc.7b02909⟩

Our study of the synthesis of the aglycone of tiacumicin B is discussed here. We imagined two possible strategies featuring a main retrosynthetic disconnection between C13 and C14. The first strategy was based on Suzuki–Miyaura cross-coupling of 1,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0ac1d6302309282ab308c6351be188b
https://hal.science/hal-02325613