Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Vincent, Poitout"'
Autor:
Julie Lacombe, Kevin Guo, Jessica Bonneau, Denis Faubert, Florian Gioanni, Alexis Vivoli, Sarah M. Muir, Soraya Hezzaz, Vincent Poitout, Mathieu Ferron
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112500- (2023)
Summary: Vitamin K is a micronutrient necessary for γ-carboxylation of glutamic acids. This post-translational modification occurs in the endoplasmic reticulum (ER) and affects secreted proteins. Recent clinical studies implicate vitamin K in the pa
Externí odkaz:
https://doaj.org/article/db075e3aed46422494348fc8be99755a
Autor:
Anne-Laure Castell, Clara Goubault, Mélanie Ethier, Grace Fergusson, Caroline Tremblay, Marie Baltz, Dorothée Dal Soglio, Julien Ghislain, Vincent Poitout
Publikováno v:
JCI Insight, Vol 7, Iss 21 (2022)
Puberty is associated with transient insulin resistance that normally recedes at the end of puberty; however, in overweight children, insulin resistance persists, leading to an increased risk of type 2 diabetes. The mechanisms whereby pancreatic β c
Externí odkaz:
https://doaj.org/article/110a1041689d4395969f0d1a35297a40
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract The potential to treat diabetes by increasing beta-cell mass is driving a major effort to identify beta-cell mitogens. Demonstration of mitogen activity in human beta cells is frequently performed in ex vivo assays. However, reported dispari
Externí odkaz:
https://doaj.org/article/0c5672ccf4384164a7461795c4eafad4
Autor:
Mark H. Dornan, Daniil Petrenyov, José-Mathieu Simard, Antonio Aliaga, Guoming Xiong, Julien Ghislain, Barry Bedell, Vincent Poitout, Jean N. DaSilva
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 3, Iss 1, Pp 1-15 (2018)
Abstract Background The free-fatty acid receptor-1 (FFA-1) is expressed by β-cells and is a promising target for molecular imaging of functional β-cell mass. Recently, the ((3-[18F]fluoropropyl)sulfonyl)propoxy-derivative of the high-affinity FFA-1
Externí odkaz:
https://doaj.org/article/c7921ef1b9984e53b76aa893df52a43c
Autor:
Marine L. Croze, Marcus F. Flisher, Arthur Guillaume, Caroline Tremblay, Glyn M. Noguchi, Sabrina Granziera, Kevin Vivot, Vincent C. Castillo, Scott A. Campbell, Julien Ghislain, Mark O. Huising, Vincent Poitout
Publikováno v:
Molecular Metabolism, Vol 45, Iss , Pp 101166- (2021)
Objective: Maintenance of glucose homeostasis requires the precise regulation of hormone secretion from the endocrine pancreas. Free fatty acid receptor 4 (FFAR4/GPR120) is a G protein-coupled receptor whose activation in islets of Langerhans promote
Externí odkaz:
https://doaj.org/article/d4cba72dc14e46cfaebece614a2320bc
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/3e5cc5495bc7412f887eadc484a90f6b
Autor:
Shara Khan, Mourad Ferdaoussi, Austin Bautista, Valérie Bergeron, Nancy Smith, Vincent Poitout, Patrick E. MacDonald
Publikováno v:
Physiological Reports, Vol 7, Iss 19, Pp n/a-n/a (2019)
Abstract Along with insulin, β‐cells co‐secrete the neurotransmitter ATP which acts as a positive autocrine signal via P2Y1 receptors to activate phospholipase C and increase the production of diacylglycerol (DAG). However, the downstream signal
Externí odkaz:
https://doaj.org/article/7f4f2db399fa4aa6897e2125905924a3
Autor:
Kevin Vivot, Valentine S. Moullé, Bader Zarrouki, Caroline Tremblay, Arturo D. Mancini, Hasna Maachi, Julien Ghislain, Vincent Poitout
Publikováno v:
Molecular Metabolism, Vol 5, Iss 10, Pp 988-996 (2016)
Objective: G protein-coupled receptor (GPCR) signaling regulates insulin secretion and pancreatic β cell-proliferation. While much knowledge has been gained regarding how GPCRs are activated in β cells, less is known about the mechanisms controllin
Externí odkaz:
https://doaj.org/article/ad1ede006bf142c780de5ff77a012db7
Autor:
Khalil Bouyakdan, Cindy Baldwin, Scott A. Campbell, Maureen Gannon, Thierry Alquier, Vincent Poitout, Nathalie Jouvet, Jennifer L. Estall, Shannon E. Townsend
Publikováno v:
Diabetes
Controllable genetic manipulation is an indispensable tool in research, greatly advancing our understanding of cell biology and physiology. However in β-cells, transgene silencing, low inducibility, ectopic expression, and off-targets effects are pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8411cb5388bccac9f8e854d716a3e775
https://doi.org/10.2337/db21-0147
https://doi.org/10.2337/db21-0147
Autor:
Daniel Oropeza, Nathalie Jouvet, Khalil Bouyakdan, Gabrielle Perron, Lea-Jeanne Ringuette, Louis H. Philipson, Robert S. Kiss, Vincent Poitout, Thierry Alquier, Jennifer L. Estall
Publikováno v:
Molecular Metabolism, Vol 4, Iss 11, Pp 811-822 (2015)
Objectives: Peroxisome proliferator-activated receptor γ coactivator 1 (PPARGCA1, PGC-1) transcriptional coactivators control gene programs important for nutrient metabolism. Islets of type 2 diabetic subjects have reduced PGC-1α expression and thi
Externí odkaz:
https://doaj.org/article/1935dd6aa91c47d5ae94162df6f8e61d