Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Vincent, Nadeem"'
Autor:
Nan Zhong, Peter Loppnau, Alma Seitova, Mani Ravichandran, Maria Fenner, Harshika Jain, Anandi Bhattacharya, Ashley Hutchinson, Marcin Paduch, Vincent Lu, Michal Olszewski, Anthony A Kossiakoff, Evan Dowdell, Akiko Koide, Shohei Koide, Haiming Huang, Vincent Nadeem, Sachdev S Sidhu, Jack F Greenblatt, Edyta Marcon, Cheryl H Arrowsmith, Aled M Edwards, Susanne Gräslund
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0139695 (2015)
We developed and optimized a high-throughput project workflow to generate renewable recombinant antibodies to human proteins involved in epigenetic signalling. Three different strategies to produce phage display compatible protein antigens in bacteri
Externí odkaz:
https://doaj.org/article/dd18dddf47c540eb9b460223ee62eb80
Autor:
Jun Gu, Shane Miersch, Bernard A. Liu, Nick Jarvik, Sachdev S. Sidhu, Nicolas O. Economopoulos, Haiming Huang, Vincent Nadeem, Jason Moffat, Tony Pawson, Andrea Uetrecht
Publikováno v:
Protein Science. 24:1890-1900
Antibodies are indispensable tools in biochemical research and play an expanding role as therapeutics. While hybridoma technology is the dominant method for antibody production, phage display is an emerging technology. Here, we developed and employed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::588c4ba25e37baba440f0a14f490ecac
https://doi.org/10.1002/pro.2799
https://doi.org/10.1002/pro.2799
Autor:
Fuqiang Ban, Dan Chi-Chia Lin, Erin Green, Sze-Wan Li, Guohua J. Pan, Richard J. Hodgson, Miklos Feher, Yong Liu, Wei Qiu, Olga Plotnikova, Narendra Kumar B. Patel, Grace Ng, Marees Harris-Brandts, Guodong Mao, Nickolay Y. Chirgadze, Don E. Awrey, Irina Beletskaya, Henry W. Pauls, Yunhui Lang, Ping Huang, Vincent Nadeem, Xin Wei, Tak W. Mak, Genie Leung, Reza Kiarash, Jacqueline M. Mason, Louise Edwards, Radoslaw Laufer, Xunyi Luo
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:4968-4997
TTK kinase was identified by in-house siRNA screen and pursued as a tractable, novel target for cancer treatment. A screening campaign and systematic optimization, supported by computer modeling led to an indazole core with key sulfamoylphenyl and ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c63402e43dae5221f6ff6a1f83b914c
https://doi.org/10.1016/j.bmc.2014.06.027
https://doi.org/10.1016/j.bmc.2014.06.027
Autor:
Peter B. Sampson, Yong Liu, Bryan Forrest, Graham Cumming, Sze-Wan Li, Narendra Kumar Patel, Louise Edwards, Radoslaw Laufer, Miklos Feher, Fuqiang Ban, Donald E. Awrey, Guodong Mao, Olga Plotnikova, Richard Hodgson, Irina Beletskaya, Jacqueline M. Mason, Xunyi Luo, Vincent Nadeem, Xin Wei, Reza Kiarash, Brian Madeira, Ping Huang, Tak W. Mak, Guohua Pan, Henry W. Pauls
Publikováno v:
Journal of Medicinal Chemistry. 58:147-169
Previous publications from our laboratory have introduced novel inhibitors of Polo-like kinase 4 (PLK4), a mitotic kinase identified as a potential target for cancer therapy. The search for potent and selective PLK4 inhibitors yielded (E)-3-((1H-inda
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09a88499af90e226793ff88203ec36fb
https://doi.org/10.1021/jm5005336
https://doi.org/10.1021/jm5005336
Autor:
Haiming, Huang, Nicolas O, Economopoulos, Bernard A, Liu, Andrea, Uetrecht, Jun, Gu, Nick, Jarvik, Vincent, Nadeem, Tony, Pawson, Jason, Moffat, Shane, Miersch, Sachdev S, Sidhu
Publikováno v:
Protein science : a publication of the Protein Society. 24(11)
Antibodies are indispensable tools in biochemical research and play an expanding role as therapeutics. While hybridoma technology is the dominant method for antibody production, phage display is an emerging technology. Here, we developed and employed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::06e9cc84cc27766c0ef20fad760aeb52
https://pubmed.ncbi.nlm.nih.gov/26332758
https://pubmed.ncbi.nlm.nih.gov/26332758
Autor:
Peter B, Sampson, Yong, Liu, Bryan, Forrest, Graham, Cumming, Sze-Wan, Li, Narendra Kumar, Patel, Louise, Edwards, Radoslaw, Laufer, Miklos, Feher, Fuqiang, Ban, Donald E, Awrey, Guodong, Mao, Olga, Plotnikova, Richard, Hodgson, Irina, Beletskaya, Jacqueline M, Mason, Xunyi, Luo, Vincent, Nadeem, Xin, Wei, Reza, Kiarash, Brian, Madeira, Ping, Huang, Tak W, Mak, Guohua, Pan, Henry W, Pauls
Publikováno v:
Journal of medicinal chemistry. 58(1)
Previous publications from our laboratory have introduced novel inhibitors of Polo-like kinase 4 (PLK4), a mitotic kinase identified as a potential target for cancer therapy. The search for potent and selective PLK4 inhibitors yielded (E)-3-((1Hindaz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::160efe8c1bbad6cc1acf1625e82022f2
https://pubmed.ncbi.nlm.nih.gov/25723005
https://pubmed.ncbi.nlm.nih.gov/25723005
Autor:
Suzanne K. Sawyer, Tak W. Mak, Tuula Kalliomaki, Brandon Faubert, Andrew E. H. Elia, Jennifer Silvester, Benjamin J. Fuerth, Ming Tsao, Karuppiah Kannan, Yao Yi, Annick You Ten, Jacqueline M. Mason, Vincent Nadeem, Murray O. Robinson, Ping Huang, Walbert Bakker, Russell G. Jones, Sireesha Yalavarthi, David Bungard, Craig B. Thompson, Kathrin Zaugg, Shelley L. Berger, Joseph D. Growney, Andrew Wakeham, Guohua Pan, Yasmin Moolani, Patrick T. Reilly, Katsuya Tsuchihara, Richard P. Hill, Reza Kiarash, Xunyi Luo
Publikováno v:
Genes & development, 25(10), 1041-1051. Cold Spring Harbor Laboratory Press
Tumor cells gain a survival/growth advantage by adapting their metabolism to respond to environmental stress, a process known as metabolic transformation. The best-known aspect of metabolic transformation is the Warburg effect, whereby cancer cells u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::142b9169e7b4d854f2187d954ae53193
https://pure.amc.nl/en/publications/carnitine-palmitoyltransferase-1c-promotes-cell-survival-and-tumor-growth-under-conditions-of-metabolic-stress(7ba92f8a-2442-4232-9526-e4d1558c9bb9).html
https://pure.amc.nl/en/publications/carnitine-palmitoyltransferase-1c-promotes-cell-survival-and-tumor-growth-under-conditions-of-metabolic-stress(7ba92f8a-2442-4232-9526-e4d1558c9bb9).html
Autor:
Vincent Nadeem, Zhihua Li, Suzanne Trudel, P. Leif Bergsagel, Carla Heise, David Roodman, Esther Masih-Khan, Ellen Wei, Jaime O. Claudio, Joshua Paterson, A. Keith Stewart
Publikováno v:
Blood. 108(10)
Overexpression of fibroblast growth factor receptor 3 (FGFR3) is a hallmark of t(4;14) multiple myeloma (MM). To dissect the mechanism of FGFR3 oncogenesis in MM, we used 3 FGFR selective kinase inhibitors—CHIR258, PD173074, and SU5402—and FGFR3-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f16526439f576bdea41e5b7f2e988fb5
https://pubmed.ncbi.nlm.nih.gov/16849642
https://pubmed.ncbi.nlm.nih.gov/16849642
Autor:
Ofelia Francisco-Pabalan, Zhi Hua Li, James R. Woodgett, Esther Masih-Khan, Choong Chin Liew, A. Keith Stewart, Jason Goncalves, Eva Cukerman, Michael Voralia, Vincent Nadeem, Hongchang Tang, Jaime O. Claudio
Publikováno v:
Blood. 100(6)
We have created a molecular resource of genes expressed in primary malignant plasma cells using a combination of cDNA library construction, 5' end single-pass sequencing, bioinformatics, and microarray analysis. In total, we identified 9732 nonredund
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0a20fec975b45eea81ae1218c589065
https://pubmed.ncbi.nlm.nih.gov/12200383
https://pubmed.ncbi.nlm.nih.gov/12200383
Autor:
Vincent Nadeem, Reza Kiarash, Peter Brent Sampson, Sam Wei, Radek Laufer, Irina Beletskaya, Henry W. Pauls, Jacqueline M. Mason, Sze-Wan Li, Xunyi Luo, Miklos Feher, Yong Liu, Bryan T. Forrest, Genie Leung, James Guohua Pan, Don Awrey, Yunhui Lang, Tak W. Mak, Ping Huang
Publikováno v:
Cancer Research. 71:LB-215
Polo-like kinase 4 or PLK4 is a member of a conserved family of serine/threonine protein kinases that regulate multiple cellular processes, such as cell division and checkpoint regulation of mitosis. These kinases are often deregulated in cancer. PLK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7350b1cd6e66c1170f0e83c853224924
https://doi.org/10.1158/1538-7445.am2011-lb-215
https://doi.org/10.1158/1538-7445.am2011-lb-215