Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Vince Tong"'
Autor:
Joey L. Methot, Hua Zhou, Sam D. Kattar, Meredeth A. McGowan, Kevin Wilson, Yudith Garcia, Yongi Deng, Michael Altman, Xavier Fradera, Charles Lesburg, Thierry Fischmann, Chaomin Li, Steve Alves, Sanjiv Shah, Rafael Fernandez, Peter Goldenblatt, Armetta Hill, Lynsey Shaffer, Dapeng Chen, Vince Tong, Robbie L. McLeod, Hongshi Yu, Alan Bass, Ray Kemper, Nicholas T. Gatto, Lisa LaFranco-Scheuch, Benjamin Wesley Trotter, Timothy Guzi, Jason D. Katz
Publikováno v:
Journal of Medicinal Chemistry. 62:4370-4382
PI3Kδ catalytic activity is required for immune cell activation, and has been implicated in inflammatory diseases as well as hematological malignancies in which the AKT pathway is overactive. A purine PI3Kδ inhibitor bearing a benzimidazolone-piper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22455e06a228a36e7b0e36ea97794591
https://doi.org/10.1021/acs.jmedchem.8b01818
https://doi.org/10.1021/acs.jmedchem.8b01818
Autor:
Haifeng Tang, Kashmira Shah, Maria L. Garcia, Alexander Pasternak, Magdalena Alonso-Galicia, Brande Thomas-Fowlkes, Cordelia Rasa, Joseph M. Metzger, Sophie Roy, Lee-Yuh Pai, Jessica Liu, Olga Price, Vince Tong, Birgit T. Priest, Gregory J. Kaczorowski, James D. Ormes, Charles Gill, Aaron Corona, John P. Felix, Jianying Xiao, Kathleen A. Sullivan, Karen Owens, Caryn Hampton, Xiaoyan Zhou, Martin Köhler
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 359(1)
The renal outer medullary potassium (ROMK) channel, located at the apical surface of epithelial cells in the thick ascending loop of Henle and cortical collecting duct, contributes to salt reabsorption and potassium secretion, and represents a target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6a55d5d0f3672edd7db9d025d76d0fd
https://pubmed.ncbi.nlm.nih.gov/27432892
https://pubmed.ncbi.nlm.nih.gov/27432892
Autor:
Ravi Katwaru, Kenneth D. Anderson, Ralph S. Mazenko, Matt Zrada, Natasa Pajkovic, Lucinda H. Cohen, Paul Harradine, Haiping Wang, Bernard K. Choi, Kathy Cox, Vince Tong
Publikováno v:
Journal of pharmaceutical sciences. 103(10)
The experimental measurement of plasma protein binding is a useful in vitro Absorption Distribution Metabolism and Excretion(ADME) assay currently conducted in both screening and definitive early development candidate modes. The fraction unbound is u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30105c0102c0e24389a101557dc2e14a
https://pubmed.ncbi.nlm.nih.gov/25116691
https://pubmed.ncbi.nlm.nih.gov/25116691