Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Vince Russell"'
Autor:
Elisabetta Armani, Carmelida Capaldi, Valentina Bagnacani, Francesca Saccani, Giancarlo Aquino, Paola Puccini, Fabrizio Facchinetti, Cataldo Martucci, Nadia Moretto, Gino Villetti, Riccardo Patacchini, Maurizio Civelli, Chris Hurley, Andrew Jennings, Lilian Alcaraz, Dawn Bloomfield, Michael Briggs, Stephen Daly, Terry Panchal, Vince Russell, Sharon Wicks, Harry Finch, Mary Fitzgerald, Craig Fox, Maurizio Delcanale
Publikováno v:
Journal of Medicinal Chemistry. 65:7170-7192
The identification of novel inhaled p38α/β mitogen-activated protein kinases (MAPK) (MAPK14/11) inhibitors suitable for the treatment of pulmonary inflammatory conditions has been described. A rational drug design approach started from the identifi
Autor:
Joachim Velden, Anna Chalidou, Filippo Andreetta, Daniela Pompilio, Mauro Corsi, Viola Bigatto, Elena Manni, Mariapia Brana, Vince Russell
Publikováno v:
Mechanisms of lung injury and repair.
Biochemical evaluation of collagen content by hydroxyproline assay is one of the standard endpoints in the preclinical assessment of therapeutics for IPF. The presence of many steps in the hydroxyproline assay workflow could contribute to low assay r
Autor:
Filippo Andreetta, Vince Russell, Daniela Pompilio, M Elena Manni, Mariapia Brana, Giulia Ambrosi, Anna Chalidou, Elisa Venturini
Publikováno v:
Airway pharmacology and treatment.
Autor:
Pamela Okerholm, Paul Woodman, Sophanna Kong, Paulette W. Andreotta, Elizabeth Berry, David L. Hava, Robert W. Clarke, Diane Spicer, Vince Russell, Steve Arold, Jennifer Kenyon, Tim Brogan
Publikováno v:
Pulmonary pharmacologytherapeutics. 53
Tobacco smoke-induced lung inflammation in patients with chronic obstructive pulmonary disease (COPD) worsens with disease progression and acute exacerbations caused by respiratory infections. Chronic therapies to manage COPD center on bronchodilator
Autor:
Ken Grime, Keith Bowers, Escott Katherine Jane, Antonio Mete, Vince Russell, Andrew Mather, David Donald, Richard James Bull, Rhonan Ford, Helen Coope, Nicholas C. Ray
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:6248-6253
A novel series of muscarinic receptor antagonists was developed, with the aim of identifying a compound with high M3 receptor potency and a reduced risk of dose-limiting side effects with potential for the treatment of COPD. Initial compound modifica
Publikováno v:
5.1 Airway Pharmacology and Treatment.
Severe asthma is not controlled by normal doses of inhaled or oral corticosteroids. Patients need high dose oral steroids and there is an unmet medical need for new therapies. Neutrophilic airway inflammation, mediated by Th17 cytokines, has been ass
Autor:
Emanuelle Wakselman, Nicolas Desroy, Roland Blanque, Bertrand Heckmann, Reginald Brys, Vince Russell, Wendy Laenen, C. Cottereaux, Ellen van der Aar, Alain Monjardet, Sonia Dupont
Publikováno v:
5.1 Airway Pharmacology and Treatment.
Introduction: Autotaxin (ATX), a secreted lysophospholipase, plays a central role in the production of the bioactive lipid lysophosphatidic acid (LPA). LPA signals through multiple LPA receptors to control a range of cell activities (migration, contr
The Effect of Stimulatory Compounds on Baseline and Impaired Mucociliary Clearance in the Guinea Pig
Publikováno v:
The FASEB Journal. 29
Mucociliary clearance (MCC) is an important mechanism for clearing the lung of foreign matter and is impaired in diseases such as COPD. Smoking reduces MCC in humans and may contribute to the disea...
Publikováno v:
The FASEB Journal. 29
Severe asthma patients have symptoms that are frequently hard to manage with low dose inhaled corticosteroids (ICS) and often need additional high dose oral steroids. Neutrophilic airway inflammati...
Publikováno v:
Journal of Inflammation (London, England)
Exposure to tobacco smoke (TS) for 4 days induces a reproducible steroid-insensitive lung inflammation in the mouse. The effect of adding the viral mimetic poly IC (PIC) to TS-exposed mice was examined with the aim of defining the translational aspec