Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Vince Pozsgay"'
Autor:
Evgeny Vinogradov, Joanna Kubler-Kielb, Bruce Coxon, Vince Pozsgay, John B. Robbins, Rachel Schneerson, Christopher Mocca
Publikováno v:
Carbohydrate Research. 345:1600-1608
There is no licensed vaccine for the prevention of shigellosis. Our approach to the development of a Shigella vaccines is based on inducing serum IgG antibodies to the O-specific polysaccharide (O-SP) domain of their lipopolysaccharides (LPS). We hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ed14fc8d6358521441e325249c8dc76
https://doi.org/10.1016/j.carres.2010.05.006
https://doi.org/10.1016/j.carres.2010.05.006
Autor:
Vince Pozsgay, John B. Robbins, Evguenii Vinogradov, Christopher Mocca, Joseph Shiloach, Rachel Schneerson, Joanna Kubler-Kielb
Publikováno v:
Proceedings of the National Academy of Sciences. 106:7974-7978
Shigellosis, an enteric disease, is on the World Health Organization's priority prevention list. In one study, the Shigella sonnei O-specific polysaccharide (O-SP)-protein conjugate showed 72% protection against disease in Israeli army recruits expos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d78ad4e853074b77ed7ec4cd46d4dc6
https://doi.org/10.1073/pnas.0900891106
https://doi.org/10.1073/pnas.0900891106
Autor:
Vince Pozsgay
Publikováno v:
Current Topics in Medicinal Chemistry. 8:126-140
Synthetic advances made possible chemical assembly of complex oligosaccharide fragments of polysaccharide domains on the surface of human pathogenic bacteria. These oligosaccharides may be recognized by antibodies raised against high molecular weight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32d58e9571dfac958d95036641c9a77d
https://doi.org/10.2174/156802608783378864
https://doi.org/10.2174/156802608783378864
Publikováno v:
Proceedings of the National Academy of Sciences. 104:14478-14482
Endemic and epidemic shigellosis, an acute invasive disease of the lower intestines, afflicts millions of people worldwide with an estimated one million fatalities per annum at a low infectious dose. Our approach to vaccine development against Shigel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb4ca7d35513b3720ca5e1519dcf9870
https://doi.org/10.1073/pnas.0706969104
https://doi.org/10.1073/pnas.0706969104
Autor:
Vince Pozsgay, Anikó Fekete, John B. Robbins, Gijsbert Zomer, Joanna Kubler-Kielb, Peter Hoogerhout, Rachel Schneerson
Publikováno v:
Carbohydrate Research. 341:2037-2048
The bacterial cell-wall-associated teichoic acids contain predominantly D-ribitol residues interconnected by phosphodiester linkages. Because of their location, these antigens may be vaccine candidates as part of conjugate vaccines. Here, we describe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::345255b6cc62d0f23fd32beef8005b52
https://doi.org/10.1016/j.carres.2005.10.023
https://doi.org/10.1016/j.carres.2005.10.023
Publikováno v:
Carbohydrate Research. 341:1408-1427
Hexa- to tridecasaccharides corresponding to the O-specific polysaccharide (O-SP) of the Gram-negative bacterium Shigella dysenteriae type 1 were synthesized in solution phase. The syntheses utilized tetra-, octa-, and dodecasaccharide intermediates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fda9e27ed9ffa96228a79bcac54fbd84
https://doi.org/10.1016/j.carres.2006.04.006
https://doi.org/10.1016/j.carres.2006.04.006
Publikováno v:
Tetrahedron. 61:10470-10481
As a prelude to development of a human vaccine against Lyme disease, the first chemical synthesis of glycolipid antigens of Borrelia burkholderi is reported. First, cholesteryl β- d -galactopyranoside was synthesized and was converted to partially p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3eeb3a58f17aca9d7c74adf2ea254dbd
https://doi.org/10.1016/j.tet.2005.08.053
https://doi.org/10.1016/j.tet.2005.08.053
Publikováno v:
Synlett. :0743-0767
This review summarizes the authors' studies in the past decade aimed at developing a synthetic oligosaccharide-based glycoconjugate vaccine to prevent a serious human disease caused by the Gram negative bacterium Shigelladysenteriae type 1. Starting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::234afd2328e316bcad3fac6d8f82d25d
https://doi.org/10.1055/s-2003-38724
https://doi.org/10.1055/s-2003-38724
Publikováno v:
Chemistry - A European Journal. 8:4424-4433
Albumin conjugates of synthetic fragments of the capsular polysaccharide of the Gram-negative bacterium Neisseria meningitidis serogroup A were prepared. The fragments include monosaccharides 1 [alpha-D-ManpNAc-(1-->O)-(CH(2))(2)NH(2)] and 2 [6-O-P(O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4355c117f8f1e1c426508fd9b5dc7b44
https://doi.org/10.1002/1521-3765(20021004)8:19<4424::aid-chem4424>3.0.co
https://doi.org/10.1002/1521-3765(20021004)8:19<4424::aid-chem4424>3.0.co
Publikováno v:
Organic Letters. 4:3191-3194
Diels-Alder-type cycloaddition of an electronically matched pair of saccharide-linked conjugated dienes and a dienophile-equipped protein gives neoglycoproteins at ambient temperature in pure water with a reaction half-life of approximately 2 h. Unco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d98d21ee6fa9e68ea6d2b7a1f74bf842
https://doi.org/10.1021/ol026179v
https://doi.org/10.1021/ol026179v