PATHOMORPHOLOGICAL AND COMPUTERIZED TOMOGRAPHY STUDY OF IBUPROFEN AND COMBINATION WITH 2-PHENYL-3-CARBETHOXY-4-DIMETHYLAMINOMETHYL-5-OKSIBENZOFURAN HYDROCHLORIDE (VINBORON) INFLUENCE ON THE JOINTS OF LOWER EXTREMITIES OF RATS WITH EXPERIMENTAL RHEUMATOID ARTHRITIS

Autor: F. V. Hladkykh, V. O. Student, N. H. Stepaniuk, S. V. Vernyhorodskyi

Publikováno v: Фармация и фармакология (Пятигорск), Vol 5, Iss 5, Pp 457-486 (2017)

The most frequent adverse reactions to nonsteroidal anti-inflammatory drugs are upper and lower gastrointestinal tract disorders, hepatotoxicity, nephrotoxicity, a decrease in the synthesis of proteoglycans of the cartilaginous tissue and allergic re

Externí odkaz: https://doaj.org/article/6083359fc91e442c97f56e7e70d299f5

The study of cell homeostasis state of the gastric mucosa of rats on model of rheumatoid arthritis , treatment with ibuprofen and its combination with vinboron

Autor: F. V. Hladkykh, N. H. Stepaniuk, S. V. Vernihorodskyi

Publikováno v: Фармация и фармакология (Пятигорск), Vol 4, Iss 3(16), Pp 68-83 (2016)

Introduction. The use of NSAIDs in clinical practice is known for a significant reduction of side effects risks, among which the largest share of toxic effects on the digestive system. At the same time, the attention of researchers is increasingly pa

Externí odkaz: https://doaj.org/article/e1fb023302f843a5a3f0fe12ebdcb1dd

New approaches to reduce ulcerogenity of nonsteroidal anti-inflammatory drugs: achievements, unsolved issues and ways to optimize

Autor: F. V. Hladkykh, N. H. Stepaniuk

Publikováno v: Zaporožskij Medicinskij Žurnal, Iss 2, Pp 82-86 (2014)

Analysis of the domestic and foreign literature sources devoted to the study of pathogenetic mechanisms of gastropathy caused by non-steroidal anti-inflammatory drugs was done. Current approaches of prevention and treatment of NSAID-induced gastropat

Externí odkaz: https://doaj.org/article/253c2c6033a04b01a03885e12e70e1eb

Патоморфологическое и компьютерное томографическое исследование влияния ибупрофена и его комбинации с 2-фенил-3-карбетокси-4-диметиламинометил-5-оксибензофурана гидрохлоридом (винбороном) на состояние суставов нижних конечностей крыс с экспериментальным ревматоидным артритом

Гладких Ф. В., Судент В. Е., Степанюк Н. Г., Вернигородский С. В. Патоморфологическое и компьютерное томографическое исследование влияния и�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10548::3f9f7c8dfafb9af41751aebc7d986985
http://cryo.net.ua/xmlui/handle/123456789/207

Експериментальне обґрунтування доцільності застосування вінборону з метою підвищення знеболювальної активності ібупрофену

Autor: Hladkykh, F. V., Stepaniuk, N. H.

Publikováno v: Current issues in pharmacy and medicine: science and practice; No. 3 (2016)
Актуальные вопросы фармацевтической и медицинской науки и практики; № 3 (2016)
Актуальні питання фармацевтичної та медичної науки та практики; № 3 (2016)

Background. The increase of NSAIDs safety is current direction of modern pharmacology, because of so-called "class-specific" adverse reactions, which are common to this class, and the leading place among them is occupied by gastro-intestinal toxicity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=scientific_p::acaf04d7226b3edbd4378739fe7952f7
http://pharmed.zsmu.edu.ua/article/view/77934