Krüppel-Like Factors Orchestrate Endothelial Gene Expression Through Redundant and Non-Redundant Enhancer Networks.

Autor: Sweet DR; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute University Hospitals Cleveland Medical Center Cleveland OH.; Department of Pathology Case Western Reserve University Cleveland OH., Padmanabhan R; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute University Hospitals Cleveland Medical Center Cleveland OH., Liao X; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute University Hospitals Cleveland Medical Center Cleveland OH., Dashora HR; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute University Hospitals Cleveland Medical Center Cleveland OH., Tang X; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute University Hospitals Cleveland Medical Center Cleveland OH., Nayak L; Division of Hematology and Oncology University Hospitals Cleveland Medical Center Cleveland OH., Jain R; Department of Cell and Developmental Biology, Perelman School of Medicine University of Pennsylvania Philadelphia PA., De Val S; Department of Physiology, Anatomy and Genetics University of Oxford UK., Vinayachandran V; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute University Hospitals Cleveland Medical Center Cleveland OH., Jain MK; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute University Hospitals Cleveland Medical Center Cleveland OH.; Division of Biology and Medicine Warren Alpert Medical School of Brown University Providence RI.

Publikováno v: Journal of the American Heart Association [J Am Heart Assoc] 2023 Feb 21; Vol. 12 (4), pp. e024303. Date of Electronic Publication: 2023 Feb 15.

KLF15 controls brown adipose tissue transcriptional flexibility and metabolism in response to various energetic demands.

Autor: Fan L; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA.; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA., Lesser AF; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA.; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA., Sweet DR; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA.; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA., Keerthy KS; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA., Lu Y; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA.; Charles River Laboratories, Ashland, OH 44805, USA., Chan ER; Institute for Computational Biology, Case Western Reserve University, Cleveland, OH 44106, USA., Vinayachandran V; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA., Ilkayeva O; Sarah W. Stedman Nutrition and Metabolism Center and Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27710, USA.; Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA., Das T; Division of Biology and Medicine, Warren Alpert Medical School of Brown University, Providence, IR 02903, USA., Newgard CB; Sarah W. Stedman Nutrition and Metabolism Center and Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27710, USA.; Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.; Department of Medicine and Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA., Jain MK; Division of Biology and Medicine, Warren Alpert Medical School of Brown University, Providence, IR 02903, USA.

Publikováno v: IScience [iScience] 2022 Oct 08; Vol. 25 (11), pp. 105292. Date of Electronic Publication: 2022 Oct 08 (Print Publication: 2022).

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Structural Features of the Nucleosomal DNA Modulate the Functional Binding of a Transcription Factor and Productive Transcription.

Autor: Vinayachandran V; Centre for Cellular and Molecular Biology (Council of Scientific and Industrial Research), Hyderabad, India., Bhargava P; Centre for Cellular and Molecular Biology (Council of Scientific and Industrial Research), Hyderabad, India.

Publikováno v: Frontiers in genetics [Front Genet] 2022 May 13; Vol. 13, pp. 870700. Date of Electronic Publication: 2022 May 13 (Print Publication: 2022).

KLF2 regulates neutrophil activation and thrombosis in cardiac hypertrophy and heart failure progression.

Autor: Tang X; Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine, Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA., Wang P; Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Clinical Research Institute of Integrative Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China., Zhang R; Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine, Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA., Watanabe I; Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine, Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA., Chang E; Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine, Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA., Vinayachandran V; Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine, Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA., Nayak L; Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine, Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA., Lapping S; Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine, Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA., Liao S; Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine, Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA., Madera A; Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine, Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA., Sweet DR; Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine, Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA., Luo J; Minhang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, China., Fei J; Minhang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, China., Jeong HW; Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, Münster, Germany., Adams RH; Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, Münster, Germany., Zhang T; Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Clinical Research Institute of Integrative Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China., Liao X; Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine, Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA., Jain MK; Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine, Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2022 Feb 01; Vol. 132 (3).