Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Vinay V Eapen"'
Publikováno v:
eLife, Vol 10 (2021)
Removal of damaged organelles via the process of selective autophagy constitutes a major form of cellular quality control. Damaged organelles are recognized by a dedicated surveillance machinery, leading to the assembly of an autophagosome around the
Externí odkaz:
https://doaj.org/article/40c546596589465a886eb24ae957f951
Autor:
David P Waterman, Felix Zhou, Kevin Li, Cheng-Sheng Lee, Michael Tsabar, Vinay V Eapen, Allison Mazzella, James E Haber
Publikováno v:
PLoS Genetics, Vol 15, Iss 3, p e1008001 (2019)
We have used two different live-cell fluorescent protein markers to monitor the formation and localization of double-strand breaks (DSBs) in budding yeast. Using GFP derivatives of the Rad51 recombination protein or the Ddc2 checkpoint protein, we fi
Externí odkaz:
https://doaj.org/article/f7d1d2624d4b43669f8f1346f78bc08d
Autor:
Matteo Ferrari, Diego Dibitetto, Giuseppe De Gregorio, Vinay V Eapen, Chetan C Rawal, Federico Lazzaro, Michael Tsabar, Federica Marini, James E Haber, Achille Pellicioli
Publikováno v:
PLoS Genetics, Vol 11, Iss 1, p e1004928 (2015)
The Mre11-Rad50-Xrs2 nuclease complex, together with Sae2, initiates the 5'-to-3' resection of Double-Strand DNA Breaks (DSBs). Extended 3' single stranded DNA filaments can be exposed from a DSB through the redundant activities of the Exo1 nuclease
Externí odkaz:
https://doaj.org/article/45c4e9bf900f4165a8718166d84934cd
Publikováno v:
PLoS Genetics, Vol 6, Iss 5, p e1000973 (2010)
In budding yeast, an HO endonuclease-inducible double-strand break (DSB) is efficiently repaired by several homologous recombination (HR) pathways. In contrast to gene conversion (GC), where both ends of the DSB can recombine with the same template,
Externí odkaz:
https://doaj.org/article/5a60cc8a104040e69434dd0d0d7bc5e2
Prolonged DNA Damage Checkpoint Arrest Requires Constant Renewal and the Spindle Assembly Checkpoint
Publikováno v:
bioRxiv
To prevent cell division in the presence of a DNA double-strand breaks (DSB), cell cycle progression is arrested by the DNA damage checkpoint (DDC) to allow more time for repair. In budding yeast, a single irreparable DSB arrests cells for about 12 h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35021d46b6c697a669ead49154953348
https://europepmc.org/articles/PMC10245577/
https://europepmc.org/articles/PMC10245577/
Autor:
Yu Wang, Vinay V. Eapen, Athanasios Kournoutis, Angelique Onorati, Xianting Li, Xiaoting Zhou, Murat Cetinbas, Lu Wang, Jihe Liu, Corey Bretz, Zhuo Zhou, Shannan J. Ho Sui, Srinivas Vinod Saladi, Ruslan I. Sadreyev, Peter D. Adams, Robert E. Kingston, Zhenyu Yue, Terje Johansen, Zhixun Dou
Macroautophagy (hereafter referred to as autophagy) degrades a variety of cellular components. A poorly understood area is autophagic degradation of nuclear substrates, or “nuclear autophagy”. It remains unclear what can be degraded by autophagy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a364478f98e99194046bd74d635541c0
https://doi.org/10.1101/2022.10.04.510822
https://doi.org/10.1101/2022.10.04.510822
Autor:
Jennifer Cable, Eilika Weber‐Ban, Tim Clausen, Kylie J. Walters, Michal Sharon, Daniel J. Finley, Yangnan Gu, John Hanna, Yue Feng, Sascha Martens, Anne Simonsen, Malene Hansen, Hong Zhang, Jonathan M. Goodwin, Alessio Reggio, Chunmei Chang, Liang Ge, Brenda A. Schulman, Raymond J. Deshaies, Ivan Dikic, J. Wade Harper, Ingrid E. Wertz, Nicolas H. Thomä, Mikołaj Słabicki, Judith Frydman, Ursula Jakob, Della C. David, Eric J. Bennett, Carolyn R. Bertozzi, Richa Sardana, Vinay V. Eapen, Serena Carra
Publikováno v:
Annals of the New York Academy of Sciences 1510(1), 79-99 (2022). doi:10.1111/nyas.14745
Targeted protein degradation is critical for proper cellular function and development. Protein degradation pathways, such as the ubiquitin proteasomes system, autophagy, and endosome-lysosome pathway, must be tightly regulated to ensure proper elimin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88110e83b56645cb723743deb2706a33
Autor:
Vinay V. Eapen
Lysophagy-the selective elimination of damaged lysosomes by the autophagy pathway-is a critical housekeeping mechanism in cells. This pathway surveils lysosomes and selectively demarcates terminally damaged lysosomes for elimination. Among the most u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ebaca25dab111f92954576b59696a61
https://doi.org/10.17504/protocols.io.bx8qprvw
https://doi.org/10.17504/protocols.io.bx8qprvw
Autor:
Vinay V. Eapen
Lysophagy-the selective elimination of damaged lysosomes by the autophagy pathway-is a critical housekeeping mechanism in cells. This pathway surveils lysosomes and selectively demarcates terminally damaged lysosomes for elimination. Among the most u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57d960a584dfc60aedb02d29de6ba1cd
https://doi.org/10.17504/protocols.io.bx8pprvn
https://doi.org/10.17504/protocols.io.bx8pprvn