Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Vinay S, Bansal"'
Autor:
Joseph Alex Davis, Biju Benjamin, Shahadat Ahmed, Voleti Sreedhara Rao, Vamshi Krishna Tulasi, Kona S Srinivas, Jitendra A. Sattigeri, Anil Gorakshnath Gadhave, Dhrubajyoti Datta, Balasaheb Gangadhar Jadhav, Abhijit Ray, Ian Anthony Cliffe, Pradip Kumar Bhatnagar, Tarun Jain, Sunitha Udupa, Garima Jain, Satya M. Chilla, Yogender Singh, Sachin Sethi, Geeta Vani Rayasam, Vinay S. Bansal
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:2313-2318
Designing drug candidates exhibiting polypharmacology is one of the strategies adopted by medicinal chemists to address multifactorial diseases. Metabolic disease is one such multifactorial disorder characterized by hyperglycaemia, hypertension and d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d230bbbcb31eefbb1696499371c1800
https://doi.org/10.1016/j.bmcl.2017.04.036
https://doi.org/10.1016/j.bmcl.2017.04.036
Autor:
Jay W. Ponder, John D. York, David E. Anderson, D. Eric Dollins, Stuart Endo-Streeter, Yi Ren, Vinay S. Bansal, Jian-Ping Xiong
Publikováno v:
The Journal of Biological Chemistry
Inositol polyphosphate 1-phosphatase (INPP1) is a prototype member of metal-dependent/lithium-inhibited phosphomonoesterase protein family defined by a conserved three-dimensional core structure. Enzymes within this family function in distinct pathwa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::190c6a54b8fa179990d5f5eff305f9ef
https://doi.org/10.1074/jbc.ra120.014057
https://doi.org/10.1074/jbc.ra120.014057
Autor:
Joseph Alex Davis, Gyanesh Shukla, Shivani Mittra, Vinay S. Bansal, Baddireddi Subhadra Lakshmi, S. Sujatha, Pradip Kumar Bhatnagar, Anil Kanaujia, Chandra Kant Katiyar, Suchitra Sharma
Publikováno v:
Indian Journal of Pharmacology
Aim: The mechanism of action of Annona squamosa hexane extract in mediating antihyperglycemic and antitriglyceridimic effect were investigated in this study. Materials and Methods: The effects of extract on glucose uptake, insulin receptor-β (IR-β)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c398534e2e3c53210044e0f30b754862
http://europepmc.org/articles/PMC3371453
http://europepmc.org/articles/PMC3371453
Autor:
Chanchan Pal, Jitendra A. Sattigeri, Pucha S Kumar, Shuchita Singh, Sachin Sethi, Vivek Khanna, Lalima Sharma, Biju Benjamin, A Surender, Subhasis Roy, Vinay S. Bansal, Shivani Mittra, Joseph Alex Davis
Publikováno v:
Indian Journal of Pharmacology
Aim: Dipeptidyl peptidase IV (DPP-IV) inhibition to modulate the incretin effect is a proven strategy to treat type 2 diabetes mellitus. The present study describes the pharmacological profile of a novel DPP-IV inhibitor RBx-0128, as an antidiabetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2a238ae9961307ac0511bfb7a88320c
http://europepmc.org/articles/PMC3523506
http://europepmc.org/articles/PMC3523506
Autor:
Shuchita, Singh, Subhasis, Roy, Sachin, Sethi, Biju, Benjamin, Sindhuja, Sundaram, Vivek, Khanna, Sachin R, Kandalkar, Chanchal, Pal, Rajiv, Kant, Ashok Kumar, Patra, Geetavani, Rayasam, Shivani, Mittra, Kulvinder Singh, Saini, Jyoti, Paliwal, Anita, Chugh, Shahadat, Ahmed, Jitendra, Sattigeri, Ian, Cliff, Abhijit, Ray, Vinay S, Bansal, Pradip Kumar, Bhatnagar, Joseph Alex, Davis
Publikováno v:
European Journal of Pharmacology. 652:157-163
Dipeptidyl peptidase IV (DPP-IV) inhibiton is a well recognized approach to treat Type 2 diabetes. RBx-0597 is a novel DPP-IV inhibitor discovered in our laboratory. The aim of the present study was to characterize the pharmacological profiles of RBx
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3d5b513e1fa7c795e5b823a6d3c1c76
https://doi.org/10.1016/j.ejphar.2010.06.001
https://doi.org/10.1016/j.ejphar.2010.06.001
Autor:
Sarika Gupta, M Garg, NS Krishna, Anita Chugh, Abhijit Ray, Sadhna Sinha, Vinay S. Bansal, Naresh Kumar, V Babu, Ashwinkumar V. Meru, Sanjay Malhotra
Publikováno v:
British Journal of Pharmacology. 160:1119-1127
Background and purpose: AE9C90CB (N- [(1R, 5S, 6R)-3-azabicyclo [3.1.0] hex-6-ylmethyl]-2-hydroxy-N-methyl-2, 2-diphenylacetamide), a novel muscarinic receptor antagonist, was synthesized for the treatment of overactive bladder. Here we describe the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c34bb43a005cb705441e48295355e51
https://doi.org/10.1111/j.1476-5381.2010.00752.x
https://doi.org/10.1111/j.1476-5381.2010.00752.x
Autor:
Joseph Alex Davis, Vinay S. Bansal, Abhijit Ray, Shuchita Singh, Shivani Mittra, Jitendra A. Sattigeri, Geetavani Rayasam, Subhasis Roy, Sachin Sethi
Publikováno v:
Indian Journal of Pharmacology
Objective : The aim of this study was to evaluate the dipeptidyl peptidase-IV (DPP-IV) inhibitor sitagliptin with respect to mode of inhibition and its in vivo duration of inhibition and efficacy in type 2 diabetes animal model. Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c33d31891b39ecacece1167d3e0279fc
http://europepmc.org/articles/PMC2941613
http://europepmc.org/articles/PMC2941613
Autor:
S. Sujatha, Baddireddi Subhadra Lakshmi, Konasubrahmanya Srinivas, Suchitra Sharma, Ruchi Tandon, Anil Kanaujia, Chandrakanth Katiyar, Rajeev Duggar, Singaravelu Anand, Simi Sarin, Kadapakkam Nandhabalan Sangeetha, Yogendra Singh, Rangarajan Badri Narayanan, Suchita Singh, Vinay S. Bansal
Publikováno v:
Journal of Diabetes. 1:99-106
Background: Cinnamomum cassia (Family: Lauraceae) is an Ayurvedic medicinal plant used traditionally for the treatment of a number of diseases, including diabetes. The hypoglycemic effect of this plant has been established in vivo. However, the effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a523338681644c7f40342384f07595da
https://doi.org/10.1111/j.1753-0407.2009.00022.x
https://doi.org/10.1111/j.1753-0407.2009.00022.x
Publikováno v:
Drug Discovery Today. 13:211-218
Insulin resistance, the essential component of metabolic syndrome, has traditionally been defined from a glucocentric viewpoint, with glucotoxicity playing a lead role. However, as overabundant circulating fatty acids are now known to be overt contri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4dc024a5d9ee9b80d45536b2b29b315
https://doi.org/10.1016/j.drudis.2008.01.006
https://doi.org/10.1016/j.drudis.2008.01.006
Autor:
Priyanka Priyadarsiny, Shivani Mittra, Jitendra A. Sattigeri, Kulvinder Singh Saini, Shuchita Singh, Joseph Alex Davis, Dipak C. Mahajan, Arti Dhar, Vinay S. Bansal, Vivek Khanna, Subhasis Roy
Publikováno v:
Life Sciences. 81:72-79
Thiazolidinediones (TZDs) are currently the most efficacious class of oral antidiabetics. However, they carry the burden of weight gain and haemodilution, which may lead to cardiovascular complications. The present study was designed to ascertain whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c3fb2e62552520dd8fc67b6f19d06b6
https://doi.org/10.1016/j.lfs.2007.04.026
https://doi.org/10.1016/j.lfs.2007.04.026