Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Vinay Mandati"'
1
Akademický článek
Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2
Autor: Krishna Chinthalapudi, Vinay Mandati, Jie Zheng, Andrew J. Sharff, Gerard Bricogne, Patrick R. Griffin, Joseph Kissil, Tina Izard
Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Neurofibromin 2 (NF2) is a tumour suppressor that inhibits cell growth. Here the authors combine functional, biochemical, and structural studies and show that lipid-bound NF2 adopts an open conformation and that NF2 lipid binding is required for inhi
Externí odkaz: https://doaj.org/article/6a39c45334a64f2096f37fa863eb2504
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2
Akademický článek
AMOTL1 Promotes Breast Cancer Progression and Is Antagonized by Merlin
Autor: Christophe Couderc, Alizée Boin, Laetitia Fuhrmann, Anne Vincent-Salomon, Vinay Mandati, Yann Kieffer, Fatima Mechta-Grigoriou, Laurence Del Maestro, Philippe Chavrier, David Vallerand, Isabelle Brito, Thierry Dubois, Leanne De Koning, Daniel Bouvard, Daniel Louvard, Alexis Gautreau, Dominique Lallemand
Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 18, Iss 1, Pp 10-24 (2016)
The Hippo signaling network is a key regulator of cell fate. In the recent years, it was shown that its implication in cancer goes well beyond the sole role of YAP transcriptional activity and its regulation by the canonical MST/LATS kinase cascade.
Externí odkaz: https://doaj.org/article/65fed6073f234ef3a7b64bdb4bb40922
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3
Akademický článek
Regulation of localization and function of the transcriptional co-activator YAP by angiomotin
Autor: Susana Moleirinho, Sany Hoxha, Vinay Mandati, Graziella Curtale, Scott Troutman, Ursula Ehmer, Joseph L Kissil
Publikováno v: eLife, Vol 6 (2017)
The Hippo-YAP pathway is a central regulator of cell contact inhibition, proliferation and death. There are conflicting reports regarding the role of Angiomotin (Amot) in regulating this pathway. While some studies suggest a YAP-inhibitory function o
Externí odkaz: https://doaj.org/article/54ca03b3344f4eaa95be9a5b5a8a8d5e
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4
Supplemental data from YAP Mediates Tumorigenesis in Neurofibromatosis Type 2 by Promoting Cell Survival and Proliferation through a COX-2–EGFR Signaling Axis
Autor: Joseph L. Kissil, Anat Stemmer-Rachamimov, Mohammad Fallahi, Vinay Mandati, Scott Troutman, Smitha Kota, William Guerrant
Supplemental figures, methods and tables. Figure S1 (related to Figure 1): YAP activity is required for NF2-null Schwann cell proliferation. Figure S2 (related to Figure 2): YAP is required for colony formation in vitro and tumor growth in vivo. Figu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a0ef2f400dfce03fcc66a73d7ab68b4
https://doi.org/10.1158/0008-5472.22409765.v1
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5
Data from YAP Mediates Tumorigenesis in Neurofibromatosis Type 2 by Promoting Cell Survival and Proliferation through a COX-2–EGFR Signaling Axis
Autor: Joseph L. Kissil, Anat Stemmer-Rachamimov, Mohammad Fallahi, Vinay Mandati, Scott Troutman, Smitha Kota, William Guerrant
The Hippo–YAP pathway has emerged as a major driver of tumorigenesis in many human cancers. YAP is a transcriptional coactivator and while details of YAP regulation are quickly emerging, it remains unknown what downstream targets are critical for t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45fff02ab566eecb5121941ff60fdd61
https://doi.org/10.1158/0008-5472.c.6507857
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7
Validation of Bromodomain and Extraterminal proteins as therapeutic targets in neurofibromatosis type 2
Autor: Joanne Doherty, Vinay Mandati, Maria A González Rodriguez, Scott Troutman, Alyssa Shepard, David Harbaugh, Rachel Brody, Douglas C Miller, Michael S Kareta, Joseph L Kissil
Publikováno v: Neuro-Oncology Advances. 4
Background Neurofibromatosis type 2 (NF2) is an autosomal dominant genetic disease characterized by development of schwannomas on the VIIIth (vestibular) cranial nerves. Bromodomain and extra-terminal domain (BET) proteins regulate gene transcription
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::233327ae756fffbd41e1e093ed1652d4
https://doi.org/10.1093/noajnl/vdac072
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8
Phosphorylation of Merlin by Aurora A kinase appears necessary for mitotic progression
Autor: Florent Dingli, Dominique Lallemand, Damarys Loew, Daniel Bouvard, Stéphane Romero, Laurence Del Maestro, Vinay Mandati, Bérangère Lombard, Eric Pasmant, Alexis Gautreau, Daniel Louvard, Nicolas Molinie
Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, In press, pp.jbc.RA118.006937. ⟨10.1074/jbc.RA118.006937⟩
J Biol Chem
International audience; Although Merlin function as a tumor suppressor and regulator of mitogenic signaling networks such as the Ras/rac, Akt or Hippo pathways is well documented,in mammals as well as in insects, its role during cell cycle progressio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5574ff9d7626d469fb00b2c576eb65c5
https://hal.archives-ouvertes.fr/hal-02266353/document
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9
YAP Mediates Tumorigenesis in Neurofibromatosis Type 2 by Promoting Cell Survival and Proliferation through a COX-2–EGFR Signaling Axis
Autor: Anat Stemmer-Rachamimov, Smitha Kota, William Guerrant, Vinay Mandati, Joseph L. Kissil, Mohammad Fallahi, Scott Troutman
Publikováno v: Cancer Research. 76:3507-3519
The Hippo–YAP pathway has emerged as a major driver of tumorigenesis in many human cancers. YAP is a transcriptional coactivator and while details of YAP regulation are quickly emerging, it remains unknown what downstream targets are critical for t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe3dd29f9da294c7b6c6f358ec28e2d7
https://doi.org/10.1158/0008-5472.can-15-1144
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10
Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2
Autor: Jie Zheng, Tina Izard, Krishna Chinthalapudi, Patrick R. Griffin, Andrew J. Sharff, Gérard Bricogne, Joseph L. Kissil, Vinay Mandati
Publikováno v: Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Neurofibromatosis type 2 (NF2) is a tumor-forming disease of the nervous system caused by deletion or by loss-of-function mutations in NF2, encoding the tumor suppressing protein neurofibromin 2 (also known as schwannomin or merlin). Neurofibromin 2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635c9d5e50d4a78f81b2aff73cb99fec
http://europepmc.org/articles/PMC5889391
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