Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Vinay Kumar, Nandicoori"'
Autor:
Meetu Agarwal, Ashima Bhaskar, Biplab Singha, Suparba Mukhopadhyay, Isha Pahuja, Archna Singh, Shivam Chaturvedi, Nisheeth Agarwal, Ved Prakash Dwivedi, Vinay Kumar Nandicoori
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract The limitations of TB treatment are the long duration and immune-dampening effects of anti-tuberculosis therapy. The Cell wall plays a crucial role in survival and virulence; hence, enzymes involved in its biosynthesis are good therapeutic t
Externí odkaz:
https://doaj.org/article/578dbbd1d59c4fc6ba88486f2c23318f
Autor:
Mehak Zahoor Khan, Debbie M Hunt, Biplab Singha, Yogita Kapoor, Nitesh Kumar Singh, D V Sai Prasad, Sriram Dharmarajan, Divya Tej Sowpati, Luiz Pedro S de Carvalho, Vinay Kumar Nandicoori
Publikováno v:
eLife, Vol 12 (2024)
Mycobacterium tuberculosis’s (Mtb) autarkic lifestyle within the host involves rewiring its transcriptional networks to combat host-induced stresses. With the help of RNA sequencing performed under various stress conditions, we identified that gene
Externí odkaz:
https://doaj.org/article/b558623f5a1147fc896adb025fbba70c
Autor:
Basanti Malakar, Komal Chauhan, Priyadarshini Sanyal, Saba Naz, Haroon Kalam, R. P. Vivek-Ananth, Lakshya Veer Singh, Areejit Samal, Dhiraj Kumar, Vinay Kumar Nandicoori
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Virulence effectors secreted by Mycobacterium tuberculosis (Mtb) help subvert host immune mechanisms and, therefore, are critical for establishing infection and pathogenesis. However, knowledge in terms of signaling mechanisms that modulate
Externí odkaz:
https://doaj.org/article/e13fc3632c4c45f6b13bb651ec5f436d
Autor:
Smitha Soman, Somdeb Chattopadhyay, Siya Ram, Vinay Kumar Nandicoori, G. Aneeshkumar Arimbasseri
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Mycobacterium tuberculosis (Mtb) is a slow-growing, intracellular pathogen that exhibits a high GC-rich genome. Several factors, including the GC content of the genome, influence the evolution of specific codon usage biases in genomes. As a
Externí odkaz:
https://doaj.org/article/8f12d8143c1a444fb9d293e5e1a8095b
Autor:
Saba Naz, Kumar Paritosh, Priyadarshini Sanyal, Sidra Khan, Yogendra Singh, Umesh Varshney, Vinay Kumar Nandicoori
Publikováno v:
eLife, Vol 12 (2023)
The emergence of drug resistance in Mycobacterium tuberculosis (Mtb) is alarming and demands in-depth knowledge for timely diagnosis. We performed genome-wide association analysis using 2237 clinical strains of Mtb to identify novel genetic factors t
Externí odkaz:
https://doaj.org/article/53bb99a05e9d41dea155cbfcde05df1a
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101804- (2022)
Summary: We describe steps for gDNA isolation from mycobacterium strains isolated from guinea pig lungs. We detail steps for infection of guinea pigs with Mycobacterium tuberculosis, followed by in vitro growth, gDNA isolation, and whole genome seque
Externí odkaz:
https://doaj.org/article/3d620ffe0dce46bb9a14bbf94e04785b
Autor:
Suresh Kumar, Mehak Zahoor Khan, Neha Khandelwal, Chen Chongtham, Biplab Singha, Ankita Dabla, Debashree Behera, Archana Singh, Balasubramanian Gopal, G. Aneeshkumar Arimbasseri, Siddhesh S. Kamat, Vinay Kumar Nandicoori
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT Mycobacterium tuberculosis encodes ~200 transcription factors that modulate gene expression under different microenvironments in the host. Even though high-throughput chromatin immunoprecipitation sequencing and transcriptome sequencing (RNA
Externí odkaz:
https://doaj.org/article/463f904daf694b2c99ca67ae6b16d618
Autor:
Prabhjot Kaur, Marvin Rausch, Basanti Malakar, Uchenna Watson, Nikhil P. Damle, Yogesh Chawla, Sandhya Srinivasan, Kanika Sharma, Tanja Schneider, Gagan Deep Jhingan, Deepak Saini, Debasisa Mohanty, Fabian Grein, Vinay Kumar Nandicoori
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
The Mycobacterium tuberculosis kinase PknB regulates essential cell functions via interactions with muropeptides. Here the authors identify interaction sites in the extracytoplasmic PASTA domain and show that abrogation of ligand binding leads to a h
Externí odkaz:
https://doaj.org/article/229dcd6f9fca48209698162286590a15
Autor:
Saba Naz, Shruti Dabral, Sathya Narayanan Nagarajan, Divya Arora, Lakshya Veer Singh, Pradeep Kumar, Yogendra Singh, Dhiraj Kumar, Umesh Varshney, Vinay Kumar Nandicoori
Publikováno v:
PLoS Pathogens, Vol 17, Iss 3, p e1009452 (2021)
Tuberculosis caused by Mycobacterium tuberculosis (Mtb) is a significant public health concern, exacerbated by the emergence of drug-resistant TB. To combat the host's dynamic environment, Mtb encodes multiple DNA repair enzymes that play a critical
Externí odkaz:
https://doaj.org/article/ae7f2b4093a74f83a8f22169e5497d40
Autor:
Ashima Bhaskar, Santosh Kumar, Mehak Zahoor Khan, Amit Singh, Ved Prakash Dwivedi, Vinay Kumar Nandicoori
Publikováno v:
eLife, Vol 9 (2020)
Mycobacterium tuberculosis (Mtb) employs plethora of mechanisms to hijack the host defence machinery for its successful survival, proliferation and persistence. Here, we show that Mtb upregulates one of the key epigenetic modulators, NAD+ dependent h
Externí odkaz:
https://doaj.org/article/05fb94e2271e4e8293cc923a30611bc2