Ciphers and Executioners: How 3′-Untranslated Regions Determine the Fate of Messenger RNAs

Autor: Vinay K. Mayya, Thomas F. Duchaine

Publikováno v: Frontiers in Genetics, Vol 10 (2019)

The sequences and structures of 3′-untranslated regions (3′UTRs) of messenger RNAs govern their stability, localization, and expression. 3′UTR regulatory elements are recognized by a wide variety of trans-acting factors that include microRNAs (

Externí odkaz: https://doaj.org/article/a89ef5133db040b49381f3ec5a127c1d

microRNA-mediated translation repression through GYF-1 and IFE-4 in C. elegans development

Autor: Nahum Sonenberg, Mathieu N. Flamand, James A. Wohlschlegel, Alice M Lambert, Vinay K. Mayya, Thomas F. Duchaine, Seyed Mehdi Jafarnejad

Publikováno v: Mayya, V K, Flamand, M N, Lambert, A M, Jafarnejad, S M, Wohlschlegel, J A, Sonenberg, N & Duchaine, T F 2021, ' microRNA-mediated translation repression through GYF-1 and IFE-4 in C. elegans development ', Nucleic Acids Research . https://doi.org/10.1093/nar/gkab162
Nucleic Acids Research

microRNA (miRNA)-mediated gene silencing is enacted through the recruitment of effector proteins that direct translational repression or degradation of mRNA targets, but the relative importance of their activities for animal development remains unkno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab4905c393cc28ee1e390536c93351b1
https://doi.org/10.1093/nar/gkab162

Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules

Autor: Hala Fahs, Jia-Xuan Chen, Fabio Piano, Kristin C. Gunsalus, Matthias Selbach, Olivia Bay, Hin Hark Gan, Vinay K. Mayya, Thomas F. Duchaine, George Chung, P. Giselle Cipriani, John Zinno, Yu Guan, M. Gutwein

We describe MIP-1 and MIP-2, novel paralogous C. elegans germ granule components that interact with the intrinsically disordered MEG-3 protein. These proteins promote P granule condensation, form granules independently of MEG-3 in the postembryonic g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::efe93d1bc55674377c9a5a1f4ecac397
https://doi.org/10.1101/2021.06.17.448425

A non-canonical site reveals the cooperative mechanisms of microRNA-mediated silencing

Autor: Hin Hark Gan, Kristin C. Gunsalus, Vinay K. Mayya, Thomas F. Duchaine, Mathieu N. Flamand

Publikováno v: Nucleic Acids Research

Although strong evidence supports the importance of their cooperative interactions, microRNA (miRNA)-binding sites are still largely investigated as functionally independent regulatory units. Here, a survey of alternative 3΄UTR isoforms implicates a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4afc10bade60ac88f5f87f28862f7aa
https://doi.org/10.1093/nar/gkx340

On the availability of microRNA-induced silencing complexes, saturation of microRNA-binding sites and stoichiometry

Autor: Thomas F. Duchaine, Vinay K. Mayya

Publikováno v: Nucleic Acids Research

Several authors have suggested or inferred that modest changes in microRNA expression can potentiate or impinge on their capacity to mediate gene repression, and that doing so could play a significant role in diseases. Such interpretations are based

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b66637da6729296630ea75aee6c5e95f
https://doi.org/10.1093/nar/gkv720