Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Vinay K, Holenarsipur"'
Autor:
Faye Wang, Cindy Zhang, Jae Kwagh, Brian Strassle, Jinqing Li, Minxue Huang, Yunling Song, Brenda Lehman, Richard Westhouse, Kamalavenkatesh Palanisamy, Vinay K. Holenarsipur, Robert Borzilleri, Karen Augustine-Rauch
Publikováno v:
iScience, Vol 24, Iss 3, Pp 102133- (2021)
Summary: This study focused on characterizing the potential mechanism of valvular toxicity caused by TGFβ receptor inhibitors (TGFβRis) using rat valvular interstitial cells (VICs) to evaluate early biological responses to TGFβR inhibition. Three
Externí odkaz:
https://doaj.org/article/a68cd93dd958438cb620f93aecf70450
Autor:
Guanglin Luo, Ling Chen, Walter A. Kostich, Brian Hamman, Jason Allen, Amy Easton, Clotilde Bourin, Michael Gulianello, Jonathan Lippy, Susheel Nara, Sreenivasulu Naidu Pattipati, Kumaran Dandapani, Manoj Dokania, Pradeep Vattikundala, Vivek Sharma, Saravanan Elavazhagan, Manoj Kumar Verma, Manish Lal Das, Santosh Wagh, Anand Balakrishnan, Benjamin M. Johnson, Kenneth S. Santone, George Thalody, Rex Denton, Hariharan Saminathan, Vinay K. Holenarsipur, Anoop Kumar, Abhijith Rao, Siva Prasad Putlur, Sarat Kumar Sarvasiddhi, Ganesh Shankar, Justin V. Louis, Manjunath Ramarao, Charles M. Conway, Yu-Wen Li, Rick Pieschl, Yuan Tian, Yang Hong, Linda Bristow, Charles F. Albright, Joanne J. Bronson, John E. Macor, Carolyn D. Dzierba
Publikováno v:
Journal of Medicinal Chemistry. 65:4534-4564
Recent mouse knockout studies identified adapter protein-2-associated kinase 1 (AAK1) as a viable target for treating neuropathic pain. BMS-986176/LX-9211 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf11be6e3846cab6b37f029b5b93a8d
https://doi.org/10.1021/acs.jmedchem.1c02132
https://doi.org/10.1021/acs.jmedchem.1c02132
Autor:
Guanglin Luo, Ling Chen, Walter A. Kostich, Brian Hamman, Jason Allen, Amy Easton, Clotilde Bourin, Michael Gulianello, Jonathan Lippy, Susheel Nara, Tarun Kumar Maishal, Kamalraj Thiyagarajan, Prasadrao Jalagam, Sreenivasulu Naidu Pattipati, Kumaran Dandapani, Manoj Dokania, Pradeep Vattikundala, Vivek Sharma, Saravanan Elavazhagan, Manoj Kumar Verma, Manish Lal Das, Santosh Wagh, Anand Balakrishnan, Benjamin M. Johnson, Kenneth S. Santone, George Thalody, Rex Denton, Hariharan Saminathan, Vinay K. Holenarsipur, Anoop Kumar, Abhijith Rao, Siva Prasad Putlur, Sarat Kumar Sarvasiddhi, Ganesh Shankar, Justin V. Louis, Manjunath Ramarao, Charles M. Conway, Yu-Wen Li, Rick Pieschl, Yuan Tian, Yang Hong, Jonathan Ditta, Arvind Mathur, Jianqing Li, Daniel Smith, Joseph Pawluczyk, Dawn Sun, Shiuhang Yip, Dauh-Rurng Wu, Muthalagu Vetrichelvan, Anuradha Gupta, Alan Wilson, Suma Gopinathan, Suman Wason, Linda Bristow, Charles F. Albright, Joanne J. Bronson, John E. Macor, Carolyn D. Dzierba
Publikováno v:
Journal of Medicinal Chemistry. 65:4457-4480
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38224dcaf3d9ea2fabc4ac6df4a42a84
https://doi.org/10.1021/acs.jmedchem.1c02131
https://doi.org/10.1021/acs.jmedchem.1c02131
Autor:
Vinay K. Holenarsipur, Yurong Lai, W. Griffith Humphreys, Jim Zheng, Jennifer Tang, T. Thanga Mariappan, Xiaofeng Zhao, Erika Panfen, Hong Shen, Yueping Zhang
Publikováno v:
Drug Metabolism and Disposition. 49:1063-1069
As an expansion investigation of drug-drug interaction (DDI) from previous clinical trials, additional plasma endogenous metabolites were quantitated in the same subjects to further identify the potential biomarkers of organic anion transporter (OAT)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20248cc537880920ccd0a7a436b6f058
https://doi.org/10.1124/dmd.121.000486
https://doi.org/10.1124/dmd.121.000486
Autor:
Jennifer Brown, Karen E. Parrish, Andrew J. Tebben, Jonathan Lippy, Kamalavenkatesh Palanisamy, Todd Kinsella, Chetan Padmakar Darne, Vinay K. Holenarsipur, Anwar Murtaza, Muthalagu Vetrichelvan, Chunhong Yan, Karen Augustine-Rauch, Max Ruzanov, Mark Fereshteh, Upender Velaparthi, Gopal Dhar, Gregory D. Vite, Peiying Liu, Steven Sheriff, Jayakumar Sankara Warrier, Aravind Anandam, Marina Gelman, Arvind Mathur, Barri Wautlet, Robert M. Borzilleri, Hasibur Rahaman, Zheng Yang, Anuradha Gupta, Arun Kumar Gupta, Rajinder Singh, Joseph Fargnoli, Jesse Swanson
Publikováno v:
ACS Med Chem Lett
[Image: see text] Novel imidazole-based TGFβR1 inhibitors were identified and optimized for potency, selectivity, and pharmacokinetic and physicochemical characteristics. Herein, we report the discovery, optimization, and evaluation of a potent, sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57c0a6b7db9a564a606d22c0c365bdb7
https://doi.org/10.1021/acsmedchemlett.9b00552
https://doi.org/10.1021/acsmedchemlett.9b00552
Autor:
Guanglin, Luo, Ling, Chen, Walter A, Kostich, Brian, Hamman, Jason, Allen, Amy, Easton, Clotilde, Bourin, Michael, Gulianello, Jonathan, Lippy, Susheel, Nara, Tarun Kumar, Maishal, Kamalraj, Thiyagarajan, Prasadrao, Jalagam, Sreenivasulu Naidu, Pattipati, Kumaran, Dandapani, Manoj, Dokania, Pradeep, Vattikundala, Vivek, Sharma, Saravanan, Elavazhagan, Manoj Kumar, Verma, Manish Lal, Das, Santosh, Wagh, Anand, Balakrishnan, Benjamin M, Johnson, Kenneth S, Santone, George, Thalody, Rex, Denton, Hariharan, Saminathan, Vinay K, Holenarsipur, Anoop, Kumar, Abhijith, Rao, Siva Prasad, Putlur, Sarat Kumar, Sarvasiddhi, Ganesh, Shankar, Justin V, Louis, Manjunath, Ramarao, Charles M, Conway, Yu-Wen, Li, Rick, Pieschl, Yuan, Tian, Yang, Hong, Jonathan, Ditta, Arvind, Mathur, Jianqing, Li, Daniel, Smith, Joseph, Pawluczyk, Dawn, Sun, Shiuhang, Yip, Dauh-Rurng, Wu, Muthalagu, Vetrichelvan, Anuradha, Gupta, Alan, Wilson, Suma, Gopinathan, Suman, Wason, Linda, Bristow, Charles F, Albright, Joanne J, Bronson, John E, Macor, Carolyn D, Dzierba
Publikováno v:
Journal of medicinal chemistry. 65(6)
Recent mouse knockout studies identified adapter protein-2 associated kinase 1 (AAK1) as a viable target for treating neuropathic pain. Potent small-molecule inhibitors of AAK1 have been identified and show efficacy in various rodent pain models. (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1e41976413f9c4afd18a0630ac9bd2a0
https://pubmed.ncbi.nlm.nih.gov/35257579
https://pubmed.ncbi.nlm.nih.gov/35257579
Autor:
Richard A. Westhouse, Faye Wang, Jae Kwagh, Brian Strassle, Cindy X. Zhang, Robert M. Borzilleri, Minxue Huang, Vinay K. Holenarsipur, Yunling Song, Kamalavenkatesh Palanisamy, Karen Augustine-Rauch, Jinqing Li, Brenda L. Lehman
Publikováno v:
iScience
iScience, Vol 24, Iss 3, Pp 102133-(2021)
iScience, Vol 24, Iss 3, Pp 102133-(2021)
Summary This study focused on characterizing the potential mechanism of valvular toxicity caused by TGFβ receptor inhibitors (TGFβRis) using rat valvular interstitial cells (VICs) to evaluate early biological responses to TGFβR inhibition. Three T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8bd59b157c461a0b574214f67fb19f6
http://europepmc.org/articles/PMC7900227
http://europepmc.org/articles/PMC7900227
Autor:
Hamza Kandoussi, T. Thanga Mariappan, Jianing Zeng, Vinay K. Holenarsipur, Yueping Zhang, Michael Sinz, Hong Shen
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 48(10)
Probenecid (PROB) is a clinical probe inhibitor of renal organic anion transporter (OAT) 1 and OAT3 that inhibits in vitro activity of hepatic drug transporters OATP1B1 and OATP1B3. It was hypothesized that PROB could potentially affect the dispositi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699875fec11144f67a9ef27720f3ed52
https://pubmed.ncbi.nlm.nih.gov/32723847
https://pubmed.ncbi.nlm.nih.gov/32723847
Autor:
T. Thanga Mariappan, Petia Shipkova, Joseph L. Cantone, Prabhakar Rajanna, Hong Shen, Jinping Gan, W. Griffith Humphreys, Shashyendra Singh Gautam, Dieter M. Drexler, Yueping Zhang, Vinay K. Holenarsipur, Punit Marathe
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 368:136-145
Plasma pyridoxic acid (PDA) and homovanillic acid (HVA) were recently identified as novel endogenous biomarkers of organic anion transporter (OAT) 1/3 function in monkeys. Consequently, this clinical study assessed the dynamic changes and utility of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90699d7ec3940e0a5942d9f499048583
https://doi.org/10.1124/jpet.118.252643
https://doi.org/10.1124/jpet.118.252643
Autor:
Ajay Saxena, Vinay K. Holenarsipur, Shweta Padmanabhan, Abhijith Rao, Yogesh Kumar Gupta, Harbeer Kaur, T. Thanga Mariappan
Publikováno v:
Xenobiotica. 49:646-654
1-Aminobenzotriazole (ABT) is a mechanism-based inactivator of major cytochrome P450 (CYP) enzymes, which is used in multiple mechanistic studies. The purpose was to evaluate the effect of 2 and 16-h pretreatment regimens of ABT on the exposures of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c690a747d8b417c5c7635f1e17013c2c
https://doi.org/10.1080/00498254.2018.1489166
https://doi.org/10.1080/00498254.2018.1489166