Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Vinay Rudraraju"'
Autor:
Patricia S. Steeg, Quentin R. Smith, Victoria M. Richon, Paul S. Meltzer, Kevin Camphausen, Seth M. Steinberg, Lionel Feigenbaum, Julie L. Bronder, Robert Walker, John F. Reilly, Sean Davis, David J. Liewehr, Helen R. Thorsheim, Kaci A. Bohn, Julie A. Gaasch, Rajendar K. Mittapalli, Vinay Rudraraju, Kunal S. Taskar, Eleazar Vega-Valle, Yongzhen Qian, Natasha Flores, Matthew Johnson, Elizabeth Hargrave, Jeanne Herring, Emily Hua, Fancy C. Thomas, Paul R. Lockman, Diane Palmieri
Supplementary Data from Vorinostat Inhibits Brain Metastatic Colonization in a Model of Triple-Negative Breast Cancer and Induces DNA Double-Strand Breaks
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb52a8f4188c013d1c59ec946907de1c
https://doi.org/10.1158/1078-0432.22440621.v1
https://doi.org/10.1158/1078-0432.22440621.v1
Autor:
Quentin R. Smith, Patricia S. Steeg, Diane Palmieri, Suyun Huang, Julie A. Gaasch, Helen R. Thorsheim, Amanda Roberts, Chris E. Adkins, Kaci A. Bohn, Brunilde Gril, Vinay Rudraraju, Kunal S. Taskar, Rajendar K. Mittapalli, Paul R. Lockman
Purpose: Brain metastases of breast cancer appear to be increasing in incidence, confer significant morbidity, and threaten to compromise gains made in systemic chemotherapy. The blood–tumor barrier (BTB) is compromised in many brain metastases; ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a16907fc4bac304223f3b189fd15531
https://doi.org/10.1158/1078-0432.c.6519378
https://doi.org/10.1158/1078-0432.c.6519378
Autor:
Quentin R. Smith, Patricia S. Steeg, Diane Palmieri, Suyun Huang, Julie A. Gaasch, Helen R. Thorsheim, Amanda Roberts, Chris E. Adkins, Kaci A. Bohn, Brunilde Gril, Vinay Rudraraju, Kunal S. Taskar, Rajendar K. Mittapalli, Paul R. Lockman
CCR Translation for This Article from Heterogeneous Blood–Tumor Barrier Permeability Determines Drug Efficacy in Experimental Brain Metastases of Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77995049de131a3c3603b42e8b64a019
https://doi.org/10.1158/1078-0432.22442712
https://doi.org/10.1158/1078-0432.22442712
Autor:
Patricia S. Steeg, Quentin R. Smith, Victoria M. Richon, Paul S. Meltzer, Kevin Camphausen, Seth M. Steinberg, Lionel Feigenbaum, Julie L. Bronder, Robert Walker, John F. Reilly, Sean Davis, David J. Liewehr, Helen R. Thorsheim, Kaci A. Bohn, Julie A. Gaasch, Rajendar K. Mittapalli, Vinay Rudraraju, Kunal S. Taskar, Eleazar Vega-Valle, Yongzhen Qian, Natasha Flores, Matthew Johnson, Elizabeth Hargrave, Jeanne Herring, Emily Hua, Fancy C. Thomas, Paul R. Lockman, Diane Palmieri
Purpose: As chemotherapy and molecular therapy improve the systemic survival of breast cancer patients, the incidence of brain metastases increases. Few therapeutic strategies exist for the treatment of brain metastases because the blood-brain barrie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2c66b23241e3460ce2a7a894a329269
https://doi.org/10.1158/1078-0432.c.6517923.v1
https://doi.org/10.1158/1078-0432.c.6517923.v1
Autor:
Quentin R. Smith, Patricia S. Steeg, Diane Palmieri, Suyun Huang, Julie A. Gaasch, Helen R. Thorsheim, Amanda Roberts, Chris E. Adkins, Kaci A. Bohn, Brunilde Gril, Vinay Rudraraju, Kunal S. Taskar, Rajendar K. Mittapalli, Paul R. Lockman
Supplementary Figures S1-S9.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8677241e239abc2630c66fe7932869de
https://doi.org/10.1158/1078-0432.22442709
https://doi.org/10.1158/1078-0432.22442709
Autor:
Stephen D. Rubin, Vinay Rudraraju, Kunal S Taskar, Emily Hua, Diane Palmieri, Ramakrishna Samala, Brunilde Gril, Stephen Castellino, Paul R. Lockman, Julie A. Lockman, Patricia S. Steeg, Quentin R. Smith, Joseph W. Polli, Helen R. Thorsheim, Rajendar K. Mittapalli
Publikováno v:
Pharmaceutical Research. 29:770-781
Lapatinib, a small molecule EGFR/HER2 inhibitor, partially inhibits the outgrowth of HER2+ brain metastases in preclinical models and in a subset of CNS lesions in clinical trials of HER2+ breast cancer. We investigated the ability of lapatinib to re
Autor:
Julie A. Gaasch, Emily Hua, Lionel Feigenbaum, Patricia S. Steeg, Quentin R. Smith, Natasha M. Flores, Eleazar Vega-Valle, Kunal S Taskar, Kaci A. Bohn, Diane Palmieri, Jeanne M. Herring, Helen R. Thorsheim, Seth M. Steinberg, Paul R. Lockman, Paul S. Meltzer, David J. Liewehr, Elizabeth Hargrave, Vinay Rudraraju, Matthew Johnson, John F. Reilly, Kevin Camphausen, Victoria M. Richon, Robert L. Walker, Yongzhen Qian, Sean Davis, Rajendar K. Mittapalli, Fancy Thomas, Julie L. Bronder
Publikováno v:
Clin Cancer Res
Purpose: As chemotherapy and molecular therapy improve the systemic survival of breast cancer patients, the incidence of brain metastases increases. Few therapeutic strategies exist for the treatment of brain metastases because the blood-brain barrie
Autor:
Julie A. Gaasch, Diane Palmieri, Paul R. Lockman, Helen R. Thorsheim, Patricia S. Steeg, Satyanarayana Goda, Kunal S Taskar, Vinay Rudraraju, Quentin R. Smith, Rajendar K. Mittapalli, Fancy Thomas
Publikováno v:
Pharmaceutical Research. 26:2486-2494
We evaluated the uptake of angiopep-2 paclitaxel conjugate, ANG1005, into brain and brain metastases of breast cancer in rodents. Most anticancer drugs show poor delivery to brain tumors due to limited transport across the blood-brain barrier (BBB).
Autor:
Kunal S Taskar, Chris E. Adkins, Quentin R. Smith, Kaci A. Bohn, Julie A. Gaasch, Diane Palmieri, Vinay Rudraraju, Paul R. Lockman, Suyun Huang, Amanda Roberts, Helen R. Thorsheim, Patricia S. Steeg, Brunilde Gril, Rajendar K. Mittapalli
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 16(23)
Purpose: Brain metastases of breast cancer appear to be increasing in incidence, confer significant morbidity, and threaten to compromise gains made in systemic chemotherapy. The blood–tumor barrier (BTB) is compromised in many brain metastases; ho
Autor:
Patricia S. Steeg, Kaci A. Bohn, Quentin R. Smith, Vinay Rudraraju, Christopher E. Adkins, Rajendar K. Mittapalli, Kunal S. Taskar, Diane Palmieri, Paul R. Lockman
Publikováno v:
Cancer Research. 70:2373-2373
Introduction: High vascular density of brain metastases of breast cancer has been correlated with both poor patient prognosis and with potential chemotherapeutic success. Inversely a low vascular density implies there would be decreased distribution