Zobrazeno 1 - 10
of 319
pro vyhledávání: '"Vinay, Tergaonkar"'
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-28 (2024)
Abstract Nuclear factor-kappaB (NF-ĸB) plays a crucial role in both innate and adaptive immune systems, significantly influencing various physiological processes such as cell proliferation, migration, differentiation, survival, and stemness. The fun
Externí odkaz:
https://doaj.org/article/fbaaff45cfe44ba486d68af52f8e2194
Autor:
Qiang Lu, Dongquan Kou, Shenghan Lou, Milad Ashrafizadeh, Amir Reza Aref, Israel Canadas, Yu Tian, Xiaojia Niu, Yuzhuo Wang, Pedram Torabian, Lingzhi Wang, Gautam Sethi, Vinay Tergaonkar, Franklin Tay, Zhennan Yuan, Peng Han
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-48 (2024)
Abstract Cancer immunotherapy and vaccine development have significantly improved the fight against cancers. Despite these advancements, challenges remain, particularly in the clinical delivery of immunomodulatory compounds. The tumor microenvironmen
Externí odkaz:
https://doaj.org/article/a9c4064eb78943919ff730793f464b33
Publikováno v:
Cell Death and Disease, Vol 15, Iss 3, Pp 1-12 (2024)
Abstract Cellular responses to TNF are inherently heterogeneous within an isogenic cell population and across different cell types. TNF promotes cell survival by activating pro-inflammatory NF-κB and MAPK signalling pathways but may also trigger apo
Externí odkaz:
https://doaj.org/article/781dabfa9abf45a18d7b78ff53e0cc63
Autor:
Muhammad Sufyan Bin Masroni, Kee Wah Lee, Victor Kwan Min Lee, Siok Bian Ng, Chao Teng Law, Kok Siong Poon, Bernett Teck-Kwong Lee, Zhehao Liu, Yuen Peng Tan, Wee Ling Chng, Steven Tucker, Lynette Su-Mien Ngo, George Wai Cheong Yip, Min En Nga, Susan Swee Shan Hue, Thomas Choudary Putti, Boon Huat Bay, Qingsong Lin, Lihan Zhou, Mikael Hartman, Tze Ping Loh, Manikandan Lakshmanan, Sook Yee Lee, Vinay Tergaonkar, Huiwen Chua, Adeline Voon Hui Lee, Eric Yew Meng Yeo, Mo-Huang Li, Chan Fong Chang, Zizheng Kee, Karen Mei-Ling Tan, Soo Yong Tan, Evelyn Siew-Chuan Koay, Marco Archetti, Sai Mun Leong
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-30 (2023)
Abstract Background Social behaviors such as altruism, where one self-sacrifices for collective benefits, critically influence an organism’s survival and responses to the environment. Such behaviors are widely exemplified in nature but have been un
Externí odkaz:
https://doaj.org/article/eb9275cb0ff74a91bcbbbfb6118beefa
Autor:
Jieqiong Zhang, Zhenhua Hu, Hwa Hwa Chung, Yun Tian, Kah Weng Lau, Zheng Ser, Yan Ting Lim, Radoslaw M. Sobota, Hwei Fen Leong, Benjamin Jieming Chen, Clarisse Jingyi Yeo, Shawn Ying Xuan Tan, Jian Kang, Dennis Eng Kiat Tan, Ieng Fong Sou, Urszula Lucja McClurg, Manikandan Lakshmanan, Thamil Selvan Vaiyapuri, Anandhkumar Raju, Esther Sook Miin Wong, Vinay Tergaonkar, Ravisankar Rajarethinam, Elina Pathak, Wai Leong Tam, Ern Yu Tan, Wee-Wei Tee
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Cancer cells undergo transcriptional reprogramming to drive tumor progression and metastasis. Using cancer cell lines and patient-derived tumor organoids, we demonstrate that loss of the negative elongation factor (NELF) complex inhibits bre
Externí odkaz:
https://doaj.org/article/cb2e731233234766a276c66996f09b7a
Autor:
Sang-Yun Lee, Yvonne Teng, Miseol Son, Bosung Ku, Ho Sang Moon, Vinay Tergaonkar, Pierce Kah-Hoe Chow, Dong Woo Lee, Do-Hyun Nam
Publikováno v:
PLoS ONE, Vol 18, Iss 12, p e0295827 (2023)
[This corrects the article DOI: 10.1371/journal.pone.0251998.].
Externí odkaz:
https://doaj.org/article/a6955d48b8ff461985f3c33b9a93800d
Autor:
Fan Cao, Yu Zhang, Yichao Cai, Sambhavi Animesh, Ying Zhang, Semih Can Akincilar, Yan Ping Loh, Xinya Li, Wee Joo Chng, Vinay Tergaonkar, Chee Keong Kwoh, Melissa J. Fullwood
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-25 (2021)
Abstract Chromatin interactions play important roles in regulating gene expression. However, the availability of genome-wide chromatin interaction data is limited. We develop a computational method, chromatin interaction neural network (ChINN), to pr
Externí odkaz:
https://doaj.org/article/aeb54e97cef44add957ca873496cbdf8
Autor:
Mariana Oksdath Mansilla, Camilo Salazar-Hernandez, Sally L. Perrin, Kaitlin G. Scheer, Gökhan Cildir, John Toubia, Kristyna Sedivakova, Melinda N. Tea, Sakthi Lenin, Elise Ponthier, Erica C. F. Yeo, Vinay Tergaonkar, Santosh Poonnoose, Rebecca J. Ormsby, Stuart M. Pitson, Michael P. Brown, Lisa M. Ebert, Guillermo A. Gomez
Publikováno v:
BMC Biomedical Engineering, Vol 3, Iss 1, Pp 1-14 (2021)
Abstract Background Organoids are a reliable model used in the study of human brain development and under pathological conditions. However, current methods for brain organoid culture generate tissues that range from 0.5 to 2 mm of size, which need to
Externí odkaz:
https://doaj.org/article/bb2b7d7fa4cd4072a534f3d2e82c57e7
Autor:
Cheryl Q. E. Lee, Baptiste Kerouanton, Sonia Chothani, Shan Zhang, Ying Chen, Chinmay Kumar Mantri, Daniella Helena Hock, Radiance Lim, Rhea Nadkarni, Vinh Thang Huynh, Daryl Lim, Wei Leong Chew, Franklin L. Zhong, David Arthur Stroud, Sebastian Schafer, Vinay Tergaonkar, Ashley L. St John, Owen J. L. Rackham, Lena Ho
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Mito-SEPs are small peptides that can modulate oxidative metabolism in mitochondria. Here the authors show that C15ORF48 encodes a mito-SEP, MOCCI, capable of altering mitochondria respiration to suppress inflammation, while C15ORF48 3’ untranslate
Externí odkaz:
https://doaj.org/article/c10b340027cd468680f3b74537ae38a8
Autor:
Yichao Cai, Ying Zhang, Yan Ping Loh, Jia Qi Tng, Mei Chee Lim, Zhendong Cao, Anandhkumar Raju, Erez Lieberman Aiden, Shang Li, Lakshmanan Manikandan, Vinay Tergaonkar, Greg Tucker-Kellogg, Melissa Jane Fullwood
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Mechanisms underlying gene repression and silencers remain poorly understood. Here the authors investigate the role of H3K27me3-rich regions in the genome, as defined from clusters of H3K27me3 peaks, in regulating gene expression via looping.
Externí odkaz:
https://doaj.org/article/d3b2681ce73046bd90d6e3a3c6cb6762