Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Vinai C. Thomas"'
Autor:
Zachary Van Roy, Prabakar Arumugam, Blake P. Bertrand, Dhananjay D. Shinde, Vinai C. Thomas, Tammy Kielian
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Infection is a devastating post-surgical complication, often requiring additional procedures and prolonged antibiotic therapy. This is especially relevant for craniotomy and prosthetic joint infections (PJI), both of which are characterized
Externí odkaz:
https://doaj.org/article/b9cb3c1ff84d4d3fa443a10ad71a822a
Aconitate decarboxylase 1 mediates the acute airway inflammatory response to environmental exposures
Autor:
Aaron D. Schwab, Amy J. Nelson, Angela M. Gleason, Oliver W. Schanze, Todd A. Wyatt, Dhananjay D. Shinde, Peng Xiao, Vinai C. Thomas, Chittibabu Guda, Kristina L. Bailey, Tammy Kielian, Geoffrey M. Thiele, Jill A. Poole
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundEnvironmental lipopolysaccharide (LPS) and microbial component-enriched organic dusts cause significant lung disease. These environmental exposures induce the recruitment and activation of distinct lung monocyte/macrophage subpopulations in
Externí odkaz:
https://doaj.org/article/086fbe7825ba451eb94481bbeca9982e
Autor:
Matthew D. White, Rajendra K. Angara, Leticia Torres Dias, Dhananjay D. Shinde, Vinai C. Thomas, Leonardo Augusto
Publikováno v:
mSphere, Vol 9, Iss 7 (2024)
ABSTRACT Toxoplasma gondii, a widespread parasite, has the ability to infect nearly any nucleated cell in warm-blooded vertebrates. It is estimated that around 2 billion people globally have been infected by this pathogen. Although most healthy indiv
Externí odkaz:
https://doaj.org/article/f8a3ba51db0040308f4ec36270f048ae
Autor:
Ryan M. Singh, Sujata S. Chaudhari, Sasmita Panda, Elizabeth H. Hutfless, Cortney E. Heim, Dhananjay Shinde, Abdulelah A. Alqarzaee, Margaret Sladek, Vineet Kumar, Matthew C. Zimmerman, Paul D. Fey, Tammy Kielian, Vinai C. Thomas
Publikováno v:
Redox Biology, Vol 67, Iss , Pp 102935- (2023)
Most coagulase-negative staphylococcal species, including the opportunistic pathogen Staphylococcus epidermidis, struggle to maintain redox homeostasis and grow under nitrosative stress. Under these conditions, growth can only resume once nitric oxid
Externí odkaz:
https://doaj.org/article/8d1bfec481d548bda7212dd3f2098cab
Autor:
Emilio Bueno, Víctor Pinedo, Dhananjay D. Shinde, André Mateus, Athanasios Typas, Mikhail M. Savitski, Vinai C. Thomas, Felipe Cava
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
ABSTRACT The ubiquitous presence of toxic arsenate (AsV) in the environment has raised mechanisms of resistance in all living organisms. Generally, bacterial detoxification of AsV relies on its reduction to arsenite (AsIII) by ArsC, followed by the e
Externí odkaz:
https://doaj.org/article/c515ba3d083e48dfb4fb96cfba565291
Autor:
Itidal Reslane, Cortney R. Halsey, Amanda Stastny, Barbara J. Cabrera, Jongsam Ahn, Dhananjay Shinde, Madeline R. Galac, Margaret F. Sladek, Fareha Razvi, McKenzie K. Lehman, Kenneth W. Bayles, Vinai C. Thomas, Luke D. Handke, Paul D. Fey
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT Previous studies have found that arginine biosynthesis in Staphylococcus aureus is repressed via carbon catabolite repression (CcpA), and proline is used as a precursor. Unexpectedly, however, robust growth of S. aureus is not observed in co
Externí odkaz:
https://doaj.org/article/76799a176f054de2b81bfcac6d82938e
Autor:
Jennifer L. Endres, Sujata S. Chaudhari, Xinyan Zhang, Janani Prahlad, Shu-Qi Wang, Lily A. Foley, Sorin Luca, Jeffrey L. Bose, Vinai C. Thomas, Kenneth W. Bayles
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT The Staphylococcus aureus cidABC and lrgAB operons encode members of a well-conserved family of proteins thought to be involved in programmed cell death (PCD). Based on the structural similarities that CidA and LrgA share with bacteriophage
Externí odkaz:
https://doaj.org/article/be28907b481d4d2c83ab22a975c466e8
Autor:
Christopher Campbell, Claire Fingleton, Merve S. Zeden, Emilio Bueno, Laura A. Gallagher, Dhananjay Shinde, Jongsam Ahn, Heather M. Olson, Thomas L. Fillmore, Joshua N. Adkins, Fareha Razvi, Kenneth W. Bayles, Paul D. Fey, Vinai C. Thomas, Felipe Cava, Geremy C. Clair, James P. O’Gara
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
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Externí odkaz:
https://doaj.org/article/e4f0ec57fff44791bcf41bfd3a0e63ec
Autor:
Megan E. Bosch, Blake P. Bertrand, Cortney E. Heim, Abdulelah A. Alqarzaee, Sujata S. Chaudhari, Amy L. Aldrich, Paul D. Fey, Vinai C. Thomas, Tammy Kielian
Publikováno v:
mBio, Vol 11, Iss 5 (2020)
ABSTRACT Staphylococcus aureus is a major cause of prosthetic joint infection (PJI), which is characterized by biofilm formation. S. aureus biofilm skews the host immune response toward an anti-inflammatory profile by the increased recruitment of mye
Externí odkaz:
https://doaj.org/article/a28ab5554534410984f1724ddc449c4f
Autor:
Sujata S. Chaudhari, Minji Kim, Shulei Lei, Fareha Razvi, Abdulelah A. Alqarzaee, Elizabeth H. Hutfless, Robert Powers, Matthew C. Zimmerman, Paul D. Fey, Vinai C. Thomas
Publikováno v:
mBio, Vol 8, Iss 4 (2017)
ABSTRACT Macrophage-derived nitric oxide (NO·) is a crucial effector against invading pathogens. Yet, paradoxically, several bacterial species, including some pathogens, are known to endogenously produce NO· via nitric oxide synthase (NOS) activity
Externí odkaz:
https://doaj.org/article/093ff564b67d4755b634791f586c6334