A new and efficient procedure for the synthesis of hexahydropyrimidine-fused 1,4-naphthoquinones

Autor: Marcelo Isidoro P. Reis, Vinícius R. Campos, Jackson A. L. C. Resende, Fernando C. Silva, Vitor F. Ferreira

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 11, Iss 1, Pp 1235-1240 (2015)

A new and efficient method for the synthesis of hexahydropyrimidine-fused 1,4-naphthoquinones in one step with high yields from the reaction of lawsone with 1,3,5-triazinanes was developed.

Externí odkaz: https://doaj.org/article/3bb34ba596ba43baa0dfaa50d07bd7ff

(Phenylamino)pyrimidine-1,2,3-triazole derivatives as analogs of imatinib: searching for novel compounds against chronic myeloid leukemia

Autor: Lucas Villas Bôas Hoelz, Anna C. Cunha, Frederico Silva Castelo Branco, Mônica M. Bastos, Henayle Fernandes Canzian, Nubia Boechat, Andressa Paula de Oliveira, Jackson A. L. C. Resende, Luiz Claudio Ferreira Pimentel, Vinícius R. Campos, Rafael Ferreira Dantas, Floriano Paes Silva Junior

Publikováno v: Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry, Vol 17, Iss 1, Pp 2260-2269 (2021)

The enzyme tyrosine kinase BCR-Abl-1 is the main molecular target in the treatment of chronic myeloid leukemia and can be competitively inhibited by tyrosine kinase inhibitors such as imatinib. New potential competitive inhibitors were synthesized us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::676ba28896d90ba5557acef9e2060dee
https://pubmed.ncbi.nlm.nih.gov/34621389

Absolute Configuration of (−)-Cubebin, a Classical Lignan with Pharmacological Potential, Defined by Means of Chiroptical Spectroscopy

Autor: Thatyana R. A. Vasconcelos, Alessandra L. Valverde, Davyson de Lima Moreira, Rodolfo G. Fiorot, Ana Carolina Ferreira de Albuquerque, Arthur Ladeira Macedo, Lucas H. Martorano, José Walkimar de M. Carneiro, Fernando M. dos Santos, Vinícius R. Campos

Publikováno v: Journal of the Brazilian Chemical Society v.31 n.10 2020
Journal of the Brazilian Chemical Society
Sociedade Brasileira de Química (SBQ)
instacron:SBQ
Journal of the Brazilian Chemical Society, Volume: 31, Issue: 10, Pages: 2030-2037, Published: 09 OCT 2020

This work describes the first determination of the absolute configuration (AC) of (−)-cubebin by means of electronic circular dichroism (ECD), supported by quantum chemical calculations. The comparison of experimental ECD with the corresponding qua

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::806ef316e3a134359527073f45220397
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532020001002030

Synthesis and in vitro and in silico studies of 1H- and 2H-1,2,3-triazoles as antichagasic agents

Autor: Robson X. Faria, Vinícius R. Campos, Raíssa Maria Dos Santos Galvão, Murilo L. Bello, Vitor F. Ferreira, Fernanda P. Pauli, Thais de B. da Silva, Luana da S. M. Forezi, Kathya N.K. Ji, Ana F.M. Faria, Jackson A. L. C. Resende, Fernando de C. da Silva

Publikováno v: Bioorganic Chemistry. 116:105250

1,2,3-triazole heterocycles stand out in medicinal chemistry for having great structural diversity and bioactivities. In this study, two series of triazoles were synthesized. One was obtained by the 1,3-dipolar cycloaddition reaction between ethyl cy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e089f1f346680e8cd1971f0b716b9840
https://doi.org/10.1016/j.bioorg.2021.105250

Synthesis and antimicrobial evaluation of promising 7-arylamino-5,8-dioxo-5,8-dihydroisoquinoline-4-carboxylates and their halogenated amino compounds for treating Gram-negative bacterial infections

Autor: Marcos Vinicius Santana, Vitor F. Ferreira, Ana Carolina J. A. Silva, Juliana S. Novais, Maíra Ingrid Vitorino, Matheus O. Ferreira, Vitor G. L. Keller, Jackson A. L. C. Resende, Maria Cecília B. V. de Souza, Anna C. Cunha, Flaviana R. F. Dias, Plínio Cunha Sathler, Vinícius R. Campos, Helena Carla Castro

Publikováno v: RSC Advances. 7:18311-18320

Pathogenic bacteria may cause serious infections, such as pneumonia, which can be fatal especially to immunosuppressed individuals. Hospitalized patients are particularly susceptible to antibiotic-resistant infections, which are worsened when caused

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3af9de447c4c0053090adc702537cfbf
https://doi.org/10.1039/c7ra00825b