Distinct photo-oxidation-induced cell death pathways lead to selective killing of human breast cancer cells

Autor: Ancély F. Dos Santos, Alex Inague, Gabriel S. Arini, Letícia F. Terra, Rosangela A. M. Wailemann, André C. Pimentel, Marcos Y. Yoshinaga, Ricardo R. Silva, Divinomar Severino, Daria Raquel Q. de Almeida, Vinícius M. Gomes, Alexandre Bruni-Cardoso, Walter R. Terra, Sayuri Miyamoto, Maurício S. Baptista, Leticia Labriola

Publikováno v: Cell Death and Disease, Vol 11, Iss 12, Pp 1-12 (2020)

Abstract Lack of effective treatments for aggressive breast cancer is still a major global health problem. We have previously reported that photodynamic therapy using methylene blue as photosensitizer (MB-PDT) massively kills metastatic human breast

Externí odkaz: https://doaj.org/article/d454c2ad322f485dbf8c42ec308495e3

Necroptosis activation is associated with greater methylene blue-photodynamic therapy-induced cytotoxicity in human pancreatic ductal adenocarcinoma cells

Autor: Daria R Q, de Almeida, Ancély F, Dos Santos, Rosangela A M, Wailemann, Letícia F, Terra, Vinícius M, Gomes, Gabriel S, Arini, Ester R M, Bertoldi, Eduardo M, Reis, Maurício S, Baptista, Leticia, Labriola

Publikováno v: Photochemicalphotobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

Pancreatic ductal adenocarcinomas (PDAC) are the fourth leading cause of death due to neoplasms. In view of the urgent need of effective treatments for PDAC, photodynamic therapy (PDT) appears as a promising alternative. However, its efficacy against

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eece15e0774a2c736f3744e078782402
https://pubmed.ncbi.nlm.nih.gov/36495407

Fluence Rate Determines PDT Efficiency in Breast Cancer Cells Displaying Different GSH Levels

Autor: Leticia Labriola, Letícia Ferreira Terra, Daria Raquel Queiroz de Almeida, Rosangela A. M. Wailemann, Vinícius M. Gomes, Mauricio S. Baptista, Ancély Ferreira dos Santos, Felipe Gustavo Ravagnani, Gabriel S. Arini

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Photodynamic therapy (PDT) appears as a promising alternative in the treatment of breast cancer since it can be highly effective in curing cancer while preserving normal tissue. However, predicting outcomes in PDT still constitutes a great challenge.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a19b42d392f7098b6be9618a00e97ef5
https://doi.org/10.1111/php.13182

HSPB1 influences mitochondrial respiration in ER-stressed beta cells

Autor: Vinícius M. Gomes, Livia Rosa-Fernandes, Martin R. Larsen, Leticia Labriola, Simon Ngao Mule, Rosangela A. M. Wailemann, Giuseppe Palmisano, Janaina Macedo-da-Silva

Publikováno v: Mule, S N, Gomes, V D M, Wailemann, R A M, Macedo-da-Silva, J, Rosa-Fernandes, L, Larsen, M R, Labriola, L & Palmisano, G 2021, ' HSPB1 influences mitochondrial respiration in ER-stressed beta cells ', Biochimica et Biophysica Acta-Proteins and Proteomics, vol. 1869, no. 9, 140680 . https://doi.org/10.1016/j.bbapap.2021.140680
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Beta-cell death and dysfunction are involved in the development of type 1 and 2 diabetes. ER-stress impairs beta-cells function resulting in pro-apoptotic stimuli that promote cell death. Hence, the identification of protective mechanisms in response

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac2af094cf0383058ff54ea2d48efc7c
https://portal.findresearcher.sdu.dk/da/publications/888f688e-0903-430f-a4cd-1b9691a077f1

Systems-wide analysis of glycoprotein conformational changes by limited deglycosylation assay

Autor: Vinícius M. Gomes, Simon Ngao Mule, Daniel Quina, Martin R. Larsen, Veronica Feijoli Santiago, Morten Thaysen-Andersen, Leticia Labriola, Gilberto Santos de Oliveira, Livia Rosa-Fernandes, Giuseppe Palmisano, Joao V.P. Coutinho, Janaina Macedo-da-Silva

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Mule, S N, Rosa-Fernandes, L, Coutinho, J V P, Gomes, V D M, Macedo-da-Silva, J, Santiago, V F, Quina, D, de Oliveira, G S, Thaysen-Andersen, M, Larsen, M R, Labriola, L & Palmisano, G 2021, ' Systems-wide analysis of glycoprotein conformational changes by limited deglycosylation assay ', Journal of Proteomics, vol. 248, 104355 . https://doi.org/10.1016/j.jprot.2021.104355

A new method to probe the conformational changes of glycoproteins on a systems-wide scale, termed limited deglycosylation assay (LDA), is described. The method measures the differential rate of deglycosylation of N-glycans on natively folded proteins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::838e769f551cebc8bf7dc432dfdd3642
https://doi.org/10.1101/2021.06.04.447131