Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Vinícius Bonatto"'
Autor:
Vinícius Bonatto, Rafael F. Lameiro, Fernanda R. Rocho, Jerônimo Lameira, Andrei Leitão, Carlos A. Montanari
Publikováno v:
RSC Medicinal Chemistry. 14:201-217
This review highlights the roles of nitriles in covalent inhibitors, their reactivity, examples of pharmaceuticals containing the cyano group and recent developments of nitrile-based inhibitors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0c465b20a6fe88dc303afa7504aec8f
https://doi.org/10.1039/d2md00204c
https://doi.org/10.1039/d2md00204c
Autor:
Jerônimo Lameira, Clauber Henrique Souza da Costa, Alberto Monteiro dos Santos, Carlos A. Montanari, Vinícius Bonatto, Andrei Leitão
Publikováno v:
Journal of Chemical Information and Modeling. 60:880-889
One tactic for cysteine protease inhibition is to form a covalent bond between an electrophilic atom of the inhibitor and the thiol of the catalytic cysteine. In this study, we evaluate the reaction free energy obtained from a hybrid quantum mechanic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a316af2b29003b159ef225bd71c849
https://doi.org/10.1021/acs.jcim.9b00847
https://doi.org/10.1021/acs.jcim.9b00847
Autor:
Fernanda R. Rocho, Vinícius Bonatto, Rafael F. Lameiro, Jerônimo Lameira, Andrei Leitão, Carlos A. Montanari
Publikováno v:
Expert opinion on therapeutic patents. 32(5)
Cathepsin K (CatK) is a lysosomal cysteine protease and the predominant cathepsin expressed in osteoclasts, where it degrades the bone matrix. Hence, CatK is an attractive therapeutic target related to diseases characterized by bone resorption, like
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1791ba9826e4f35d31b73c27039a2f0e
https://pubmed.ncbi.nlm.nih.gov/35137661
https://pubmed.ncbi.nlm.nih.gov/35137661
Autor:
Fernanda dos Reis Rocho, Jerônimo Lameira, Carlos A. Montanari, Andrei Leitão, Vinícius Bonatto, Anwar Shamim, F. Javier Luque
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Covalent inhibitors are assuming central importance in drug discovery projects, especially in this pandemic scenario. Many research groups have focused their attention on inhibiting viral proteases or human proteases such as cathepsin L (hCatL). The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e79f519132be470dcbfd7afc86772fd
https://pubmed.ncbi.nlm.nih.gov/34460252
https://pubmed.ncbi.nlm.nih.gov/34460252
Autor:
Carlos A. Montanari, Sérgio de Albuquerque, Daiane Y. Tezuka, Daniel G. Silva, Caio Haddad Franco, Daniela De Vita, Andrei Leitão, Carolina B. Moraes, Jerônimo Lameira, Pedro Henrique Jatai Batista, Rodrigo Cedron, Vinícius Bonatto, Lorenzo Cianni
Publikováno v:
RSC Med Chem
The cysteine protease cruzipain is considered to be a validated target for therapeutic intervention in the treatment of Chagas disease. Hence, peptidomimetic cruzipain inhibitors having a reactive group (known as warhead) are subject to continuous st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c63942660ba038d04250032d2cef066
https://pubmed.ncbi.nlm.nih.gov/34095840
https://pubmed.ncbi.nlm.nih.gov/34095840
Autor:
Carlos A. Montanari, Jerônimo Lameira, Felipe Cardoso Prado Martins, Vinícius Bonatto, Fernanda dos Reis Rocho, Andrei Leitão, Lorenzo Cianni, Anwar Shamim
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Human cathepsin B (CatB) is an important biological target in cancer therapy. In this work, we performed a knowledge-based design approach and the synthesis of a new set of 19 peptide-like nitrile-based cathepsin inhibitors. Reported compounds were a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6916ec5e8bb037e55884c6e490bffac7
https://doi.org/10.1016/j.bmc.2020.115827
https://doi.org/10.1016/j.bmc.2020.115827
Autor:
Carlos A. Montanari, Lorenzo Cianni, Anwar Shamim, Jerônimo Lameira, Fabiana Rosini, Andrei Leitão, Fernanda dos Reis Rocho, Jean F. R. Ribeiro, Vinícius Bonatto
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Cysteine proteases (CPs) are involved in a myriad of actions that include not only protein degradation, but also play an essential biological role in infectious and systemic diseases such as cancer. CPs also act as biomarkers and can be reached by ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dc881d279c5630ca269712275f07127
https://doi.org/10.1016/j.bioorg.2020.104039
https://doi.org/10.1016/j.bioorg.2020.104039