Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Vimala H. Sethy"'
Publikováno v:
Molecular Brain Research. 50:107-112
Treatment with ibuprofen and other non-steroidal anti-inflammatory drugs (NSAIDS) has been reported to decrease the incidence as well as slow down the progression of Alzheimer's disease. Understanding the mechanism of this therapeutic effect would pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80d1ab90703b5edfa26953da93d391ff
https://doi.org/10.1016/s0169-328x(97)00168-x
https://doi.org/10.1016/s0169-328x(97)00168-x
Autor:
Vimala H. Sethy, Haiyan Wu
Publikováno v:
Pharmacology Biochemistry and Behavior. 58:609-613
The binding affinities (Ki) of U-101017 and diazepam for the GABA(A) receptor in rat cortical membranes were determined using [3H]flunitrazepam ([3H]FNZ) as the ligand. The inhibition constants of U-101017 and diazepam were 3.78 nM and 6.36 nM, respe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bce6e744656443d258585b373027d652
https://doi.org/10.1016/s0091-3057(97)00267-0
https://doi.org/10.1016/s0091-3057(97)00267-0
Publikováno v:
Neuroscience Letters. 228:45-49
The neuroprotective effects of U-101017, [7-chloro-5-[cis-3,5-dimethylpiperazine)carbonyl]-imidazole[1,5a]quinoli ne-3-carboxylate], a GABA(A) receptor partial agonist, were investigated in 3-acetylpyridine (3-AP) treated Wistar rats. A significant (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b1bbb547cbd63d9b1c874804a2e97c2
https://doi.org/10.1016/s0304-3940(97)00353-4
https://doi.org/10.1016/s0304-3940(97)00353-4
Publikováno v:
Brain Research. 733:41-45
The D 1 and D 2 dopamine receptor agonist properties of 7-hydroxy-2-( N,N -di- n -propylamino) tetraline (7-OH-DPAT) was determined by investigating the effect of this compound on rat striatal acetylcholine (ACh) concentration and increase in cAMP fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09c6ddd836f5e8b28c3f5686c7343a4f
https://doi.org/10.1016/0006-8993(96)00531-8
https://doi.org/10.1016/0006-8993(96)00531-8
Publikováno v:
Drug Development Research. 38:24-30
Antiparkinsonian drugs are dopamine agonists and they have been reported to increase striatal acetylcholine (ACh) concentrations. U-91356A is a D2 selective dopamine agonist. Therefore, it was investigated for its effect on rat striatal ACh concentra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::579c94430486f71bf3865e81abd3a892
https://doi.org/10.1002/(sici)1098-2299(199605)38:1<24::aid-ddr3>3.0.co
https://doi.org/10.1002/(sici)1098-2299(199605)38:1<24::aid-ddr3>3.0.co
Autor:
Wha Bin Im, Eric Jon Jacobsen, K. L. Belonga, Vimala H. Sethy, Donald B. Carter, J. D. Petke, L. S. Stelzer, Philip F. VonVoigtlander, Andrew H. Tang
Publikováno v:
Journal of Medicinal Chemistry. 39:3820-3836
A series of imidazo[1,5-alpha]quinoxalin-4-ones and imidazo[1,5-alpha]quinoxaline ureas containing substituted phenyl groups at the 3-position was developed. Compounds within the imidazo[1,5-alpha]quinoxaline urea series had high affinity for the GAB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54362f2ab2566324930ba2cdede281ed
https://doi.org/10.1021/jm960070+
https://doi.org/10.1021/jm960070+
Autor:
J. D. Petke, L. S. Stelzer, Donald B. Carter, Philip F. VonVoigtlander, Tenbrink Ruth E, H. K. Im, Vimala H. Sethy, Eric Jon Jacobsen, Wha Bin Im, Andrew H. Tang, K. L. Belonga
Publikováno v:
Journal of Medicinal Chemistry. 39:158-175
A series of imidazo[1,5-a]quinoxaline amides, carbamates, and ureas which have high affinity for the gamma-aminobutyric acid A/benzodiazepine receptor complex was developed. Compounds within this class have varying efficacies ranging from antagonists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5414df68ea1c5ffa659277bcc6b94528
https://doi.org/10.1021/jm940765f
https://doi.org/10.1021/jm940765f
Autor:
J. W. Mickelson, H. K. Im, Wha Bin Im, J. E. Mcgee, Donald B. Carter, Vimala H. Sethy, P. J. K. D. Schreur, Andrew H. Tang, J. D. Petke, Eric Jon Jacobsen
Publikováno v:
Journal of Medicinal Chemistry. 39:4654-4666
A series of tetracyclic imidazoquinoxaline analogs was developed which constrain the carbonyl group of the partial agonist 3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-5-[(dimethylamino)carbonyl] - 4,5-dihydroimidazo[1,5-alpha]quinoxaline (2, U-91571) away
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f0bb771133ed50fe487d93658aa2e51
https://doi.org/10.1021/jm960401i
https://doi.org/10.1021/jm960401i
Publikováno v:
Life Sciences. 58:585-590
Clozapine is an atypical antipsychotic drug, and its dopamine and muscarinic antagonist activity has been compared with haloperidol in rodents. Elevation in rat striatal acetylcholine (ACh) and mice cerebellar cGMP has been used as an agonist respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b44ecd43dfe5aff039d4650b0d4cb115
https://doi.org/10.1016/0024-3205(95)02327-5
https://doi.org/10.1016/0024-3205(95)02327-5
Publikováno v:
Journal of Medicinal Chemistry. 37:758-768
(4RS)-1-(5-Cyclopropyl-1,2,4-oxadiazol-3-yl)-12,12a-dihyd roimidazo[1,5- a]pyrrolo[2,1-c]quinoxalin-10(11H)-one (1a), 5-benzoyl-3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-4,5- dihydroimidazo[1,5-a]quinoxaline (13b), and tert-butyl (4S)-12,12a-dihydroimid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22ebb08d3ccc229d6450ed76c8afbf7f
https://doi.org/10.1021/jm00032a008
https://doi.org/10.1021/jm00032a008