Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Vimal Parkash"'
Autor:
Vimal Parkash, Yashraj Kulkarni, Josy ter Beek, Polina V. Shcherbakova, Shina Caroline Lynn Kamerlin, Erik Johansson
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Mutations in the human POLE gene are associated with tumours with high mutational loads. Here the authors provide a structural rationale for the mutagenic activity of the cancer-associated DNA polymerase ε P286R variant.
Externí odkaz:
https://doaj.org/article/347e31414f014ab19733e8e7a0a88110
Autor:
Heli Elovaara, Vimal Parkash, Ruth Fair-Mäkelä, Outi M H Salo-Ahen, Gabriela Guédez, Eva Bligt-Lindén, Janne Grönholm, Sirpa Jalkanen, Tiina A Salminen
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166935 (2016)
Sialic acid-binding immunoglobulin-like lectin-9 (Siglec-9) on leukocyte surface is a counter-receptor for endothelial cell surface adhesin, human primary amine oxidase (hAOC3), a target protein for anti-inflammatory agents. This interaction can be u
Externí odkaz:
https://doaj.org/article/8c28acb7f5c642b7be657bdfafb317fc
Evolution, three-dimensional model and localization of truncated hemoglobin PttTrHb of hybrid aspen.
Autor:
Estelle Dumont, Soile Jokipii-Lukkari, Vimal Parkash, Jaana Vuosku, Robin Sundström, Yvonne Nymalm, Suvi Sutela, Katariina Taskinen, Pauli T Kallio, Tiina A Salminen, Hely Häggman
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88573 (2014)
Thus far, research on plant hemoglobins (Hbs) has mainly concentrated on symbiotic and non-symbiotic Hbs, and information on truncated Hbs (TrHbs) is scarce. The aim of this study was to examine the origin, structure and localization of the truncated
Externí odkaz:
https://doaj.org/article/b1279006955f429bbc608b193c2db0f5
Autor:
Stephanie R Barbari, Annette K Beach, Joel G Markgren, Vimal Parkash, Elizabeth A Moore, Erik Johansson, Polina V Shcherbakova
Publikováno v:
Nucleic Acids Research. 50:8023-8040
Amino acid substitutions in the exonuclease domain of DNA polymerase ϵ (Polϵ) cause ultramutated tumors. Studies in model organisms suggested pathogenic mechanisms distinct from a simple loss of exonuclease. These mechanisms remain unclear for most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d2dc73bd5a837c870031d9aaa0023ac
https://doi.org/10.1093/nar/gkac602
https://doi.org/10.1093/nar/gkac602
Autor:
Pia Osterman, Erik Johansson, A. Elisabeth Sauer-Eriksson, Vimal Parkash, Göran O. Bylund, Josy ter Beek
Publikováno v:
'Nucleic Acids Research ', vol: 47, pages: 5712-5722 (2019)
Nucleic Acids Research
Nucleic Acids Research
DNA polymerase epsilon (Pol epsilon), the major leading-strand DNA polymerase in eukaryotes, has a catalytic subunit (Pol2) and three non-catalytic subunits. The N-terminal half of Pol2 (Pol2(CORE)) exhibits both polymerase and exonuclease activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74e702e251deca519c4a8ffa76dfbd3f
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:52801
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:52801
Autor:
Erik Johansson, Yashraj Kulkarni, Shina Caroline Lynn Kamerlin, Vimal Parkash, Polina V. Shcherbakova, Josy ter Beek
Publikováno v:
'Nature Communications ', vol: 10, pages: 373-1-373-13 (2019)
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The most frequently recurring cancer-associated DNA polymerase ε (Pol ε) mutation is a P286R substitution in the exonuclease domain. While originally proposed to increase genome instability by disrupting exonucleolytic proofreading, the P286R varia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9134284b8ceb973eb15d34a00ed8d511
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:51313
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:51313
Autor:
Esa Läärä, Soile Jokipii-Lukkari, Olga Blokhina, Robin Sundström, Nélida Leiva-Eriksson, Yvonne Nymalm, Hely Häggman, Pauli T. Kallio, J. Kalervo Hiltunen, Steffen Ohlmeier, Tiina A. Salminen, Vimal Parkash, Alexander J. Kastaniotis, Leif Bülow, Kurt V. Fagerstedt, Eija Kukkola
Publikováno v:
Plant science : an international journal of experimental plant biology. 247
Previous reports have connected non-symbiotic and truncated hemoglobins (Hbs) to metabolism of nitric oxide (NO), an important signalling molecule involved in wood formation. We have studied the capability of poplar (Populus tremula × tremuloides) H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::009eb10913ae4d3d65b3ec7373ce4f89
https://pubmed.ncbi.nlm.nih.gov/27095407
https://pubmed.ncbi.nlm.nih.gov/27095407
Autor:
Anna-Maria Brandt, Henri Niskanen, Vimal Parkash, Jyrki Heino, Jarmo Käpylä, Tiina A. Salminen, Matti Lahti, Eva Bligt, Pekka Patrikainen, Johanna Jokinen
Publikováno v:
Journal of Biological Chemistry. 286:43343-43351
We have analyzed the structure and function of the integrin α(1)I domain harboring a gain-of-function mutation E317A. To promote protein crystallization, a double variant with an additional C139S mutation was used. In cell adhesion assays, the E317A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05deb18d1b9d77e40515e7a00eef7ded
https://doi.org/10.1074/jbc.m111.261909
https://doi.org/10.1074/jbc.m111.261909
The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional
Autor:
Mart Saarma, Adrian Goldman, Johan Peränen, Esko Oksanen, Vimal Parkash, Veli-Matti Leppänen, Nisse Kalkkinen, Päivi Lindholm
Publikováno v:
Protein Engineering Design and Selection
Protein Engineering Design and Selection; Vol 22
Protein Engineering Design and Selection; Vol 22
We have solved the structures of mammalian mesencephalic astrocyte-derived neurotrophic factor (MANF) and conserved dopamine neurotrophic factor (CDNF). CDNF protects and repairs midbrain dopaminergic neurons in vivo; MANF supports their survival in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cef675a98b2e3a868980c3111ecc6db
Autor:
Mart Saarma, Heidi Virtanen, Adrian Goldman, Pia Runeberg-Roos, Vimal Parkash, Jaana M. Jurvansuu, Yulia Sidorova, Veli-Matti Leppänen, Maxim M. Bespalov
Publikováno v:
Journal of Biological Chemistry. 283:35164-35172
Glial cell line-derived neurotrophic factor (GDNF), a neuronal survival factor, binds its co-receptor GDNF family receptor α1 (GFRα1) in a 2:2 ratio and signals through the receptor tyrosine kinase RET. We have solved the GDNF2·GFRα12 complex str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39865897a77d1aad6615a7ea7c95b3c1
https://doi.org/10.1074/jbc.m802543200
https://doi.org/10.1074/jbc.m802543200