Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Vimal Parekh"'
Autor:
William McDowell, Julia Swierkosz, George Badescu, Andrew F. Kyle, Mark Frigerio, Amrita Abhilash, Ji-Won Choi, Estera Jamieson, Matthew P. Baker, XiaoBo Sheng, Matthew Bird, Penny Bryant, Ruslan Grygorash, Katarzyna Kozakowska, Korinna Henseleit, Rita Tommasi, Vimal Parekh, Kosma Jurlewicz, Karolina Peciak, Emmanuelle Laurine, Martin Pabst, Nicolas Camper, Antony Godwin, Anaïs Manin, Jeff Edwards, David Morris
Publikováno v:
Molecular Pharmaceutics. 12:1872-1879
The conjugation of monomethyl auristatin E (MMAE) to trastuzumab using a reduction bis-alkylation approach that is capable of rebridging reduced (native) antibody interchain disulfide bonds has been previously shown to produce a homogeneous and stabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bdafeb6a27047bdb000238cba2a009a
https://doi.org/10.1021/acs.molpharmaceut.5b00116
https://doi.org/10.1021/acs.molpharmaceut.5b00116
Autor:
Korinna Henseleit, Mark Frigerio, Antony Godwin, Jeff Edwards, XiaoBo Sheng, Matthew Bird, Martin Fisher, Kosma Jurlewicz, George Badescu, Amrita Abhilash, Penny Bryant, Estera Pawlisz, Ruslan Grygorash, Julia Swierkosz, Andrew F. Kyle, Monika Farys, Nicolas Camper, Vimal Parekh, Rita Tommasi
Publikováno v:
Bioconjugate Chemistry. 25:1124-1136
To improve both the homogeneity and the stability of ADCs, we have developed site-specific drug-conjugating reagents that covalently rebridge reduced disulfide bonds. The new reagents comprise a drug, a linker, and a bis-reactive conjugating moiety t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d2e41ca810ded9c08bfb53bf05fccd1
https://doi.org/10.1021/bc500148x
https://doi.org/10.1021/bc500148x
Autor:
Andrew F. Kyle, Matthew P. Baker, Carolyn Tucker, Derek Pollard, Terrence Kantner, Felicity Rudge, Antony Godwin, Gina Popa, Mark Frigerio, Hiteshri Makwana, George Badescu, Fabio Simoes, Anaïs Manin, Farzad Khayrzad, Katarzyna Kozakowska, Martin Pabst, Nicolas Camper, Dave Morris, Hemal Parekh, Paul Williams, Vimal Parekh, Xiao Bo Sheng, William McDowell, Elena De Juan, Alan Jenkins, Ricardo Resende, Aurelie Michelet, Matthew Bird
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 253
Antibody-drug conjugates (ADCs) are a promising class of anticancer agents which have undergone substantial development over the past decade and are now achieving clinical success. The development of novel site-specific conjugation technologies enabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be0466a60d8733391dc06cb6003472ec
https://pubmed.ncbi.nlm.nih.gov/28257988
https://pubmed.ncbi.nlm.nih.gov/28257988
Publikováno v:
Catal. Sci. Technol.. 2:406-414
A new type of Ru(II)/TsDPEN catalyst containing an ether-based linking tether has been prepared and shown to exhibit excellent activity in asymmetric transfer hydrogenation reactions of ketones. Related complexes containing a hydroxyl-terminated alky
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::784ecf789261b45e44f0a0fb4d810a6c
https://doi.org/10.1039/c1cy00364j
https://doi.org/10.1039/c1cy00364j
Publikováno v:
Tetrahedron: Asymmetry. 21:1549-1556
The first report of an asymmetric transfer hydrogenation, in formic acid/triethylamine, of quinolines is described. Using a Ru(II) catalyst containing a 4-carbon tether, products of up to 73% ee were formed, whilst a Rh(III)-tethered catalyst gave pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dd3f0bafce640f89d2fa75b0ba122c3
https://doi.org/10.1016/j.tetasy.2010.03.053
https://doi.org/10.1016/j.tetasy.2010.03.053
Publikováno v:
ChemInform. 43
Ruthenium monomer complex RUM, formed in situ from dimer RUD in the presence of HCOOH/Et3N, exhibits excellent activity in the title reaction of acetophenone and analogues.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dceec23650a136714055ba3d6da79b8b
https://doi.org/10.1002/chin.201221060
https://doi.org/10.1002/chin.201221060